Entity Details

Primary name SIX2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NPC8
EntryNameSIX2_HUMAN
FullNameHomeobox protein SIX2
TaxID9606
Evidenceevidence at protein level
Length291
SequenceStatuscomplete
DateCreated2001-01-11
DateModified2021-06-02

Ontological Relatives

GenesSIX2

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001822 kidney development
GO:0002062 chondrocyte differentiation
GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006606 protein import into nucleus
GO:0007501 mesodermal cell fate specification
GO:0008134 transcription factor binding
GO:0008283 cell population proliferation
GO:0009653 anatomical structure morphogenesis
GO:0009948 anterior/posterior axis specification
GO:0016477 cell migration
GO:0030278 regulation of ossification
GO:0032330 regulation of chondrocyte differentiation
GO:0042474 middle ear morphogenesis
GO:0044877 protein-containing complex binding
GO:0045596 negative regulation of cell differentiation
GO:0048557 embryonic digestive tract morphogenesis
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0072006 nephron development
GO:0072028 nephron morphogenesis
GO:0072038 mesenchymal stem cell maintenance involved in nephron morphogenesis
GO:0072137 condensed mesenchymal cell proliferation
GO:0072161 mesenchymal cell differentiation involved in kidney development
GO:0090189 regulation of branching involved in ureteric bud morphogenesis
GO:0097168 mesenchymal stem cell proliferation
GO:1902732 positive regulation of chondrocyte proliferation
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR017970 Homeobox, conserved siteSiteConserved site
IPR031701 Homeobox protein SIX1, N-terminal SD domainDomainDomain

Diseases

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