Entity Details

Primary name SIAH2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43255
EntryNameSIAH2_HUMAN
FullNameE3 ubiquitin-protein ligase SIAH2
TaxID9606
Evidenceevidence at protein level
Length324
SequenceStatuscomplete
DateCreated2004-04-26
DateModified2021-06-02

Ontological Relatives

GenesSIAH2

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0003714 transcription corepressor activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005829 cytosol
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006915 apoptotic process
GO:0007049 cell cycle
GO:0007264 small GTPase mediated signal transduction
GO:0007275 multicellular organism development
GO:0008270 zinc ion binding
GO:0016579 protein deubiquitination
GO:0031396 regulation of protein ubiquitination
GO:0031624 ubiquitin conjugating enzyme binding
GO:0042752 regulation of circadian rhythm
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043231 intracellular membrane-bounded organelle
GO:0044257 cellular protein catabolic process
GO:0048511 rhythmic process
GO:0061630 ubiquitin protein ligase activity
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1902842 negative regulation of netrin-activated signaling pathway
GO:1990000 amyloid fibril formation
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001841 Zinc finger, RING-typeDomainDomain
IPR004162 E3 ubiquitin-protein ligase SINA-like, animalFamilyFamily
IPR008974 TRAF-likeFamilyHomologous superfamily
IPR013010 Zinc finger, SIAH-typeDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR018121 Seven-in-absentia protein, TRAF-like domainDomainDomain

Diseases

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Interactions

79 interactions

InteractorPartnerSourcesPublicationsLink
SIAH2_HUMANCYBP_HUMANHPRD, MINT11389839 details
SIAH2_HUMANHIPK3_HUMANBioGRID, HPRD, MINT15231748 details
SIAH2_HUMANATN1_HUMANBioGRID, HPRD, IntAct16713569 details
SIAH2_HUMANCCBE1_HUMANBioGRID, IntAct21988832 details
SIAH2_HUMANEF1D_HUMANBioGRID, IntAct21988832 details
SIAH2_HUMANMYD88_HUMANBioGRID, IntAct21988832 details
SIAH2_HUMANUBC9_HUMANBioGRID, IntAct17533377 21988832 9334332 details
SIAH2_HUMANSTAT3_HUMANBioGRID, IntAct21988832 details
SIAH2_HUMANSETD2_HUMANBioGRID, IntAct21988832 details
SIAH2_HUMANSH3R1_HUMANBioGRID, DIP, IntAct21586138 25438054 details
SIAH2_HUMANOPRM_HUMANBioGRID, IntAct23840749 details
SIAH2_HUMANSIAH1_HUMANBioGRID, IntAct16899216 26186194 28514442 details
SIAH2_HUMANLATS2_HUMANBioGRID, DIP25438054 27030211 details
SIAH2_HUMANPEG10_HUMANBioGRID, HPRD12810624 details
SIAH2_HUMANCTIP_HUMANBioGRID, HPRD14654780 details
SIAH2_HUMANTRAF2_HUMANBioGRID, HPRD12411493 details
SIAH2_HUMANPEG3_HUMANBioGRID, HPRD10681424 details
SIAH2_HUMANVAV_HUMANBioGRID, HPRD10207103 details
SIAH2_HUMANPIAS1_HUMANBioGRID17533377 27485016 details
SIAH2_HUMANPIAS2_HUMANBioGRID17533377 details
SIAH2_HUMANPIAS3_HUMANBioGRID17533377 details
SIAH2_HUMANSNCAP_HUMANBioGRID16174773 details
SIAH2_HUMANODO2_HUMANBioGRID15466852 30771432 details
SIAH2_HUMANSYUA_HUMANBioGRID15064394 18070888 19224863 22065755 details
SIAH2_HUMANEGLN3_HUMANBioGRID15210114 16958618 25202994 details
SIAH2_HUMANPLCE1_HUMANBioGRID17998205 details
SIAH2_HUMANUBP13_HUMANBioGRID21659512 details
SIAH2_HUMANSPY2_HUMANBioGRID16888801 details
SIAH2_HUMANHIPK2_HUMANBioGRID19043406 25313037 details
SIAH2_HUMANPSMD4_HUMANBioGRID19240029 22350919 details
SIAH2_HUMANTINF2_HUMANBioGRID22064479 details
SIAH2_HUMANUBP19_HUMANBioGRID22128162 23500468 details
SIAH2_HUMANAFF1_HUMANBioGRID, HPRD15221006 details
SIAH2_HUMANDCC_HUMANBioGRID, HPRD9334332 9858595 details
SIAH2_HUMANMYPT1_HUMANBioGRID19744480 details
SIAH2_HUMANDYRK2_HUMANBioGRID22878263 details
SIAH2_HUMANPML_HUMANBioGRID14645235 details
SIAH2_HUMANTPX2_HUMANBioGRID17716627 details
SIAH2_HUMANUB2D2_HUMANBioGRID16174773 19224863 22065755 23695783 details
SIAH2_HUMANUB2D1_HUMANBioGRID18070888 19240029 26160177 details
SIAH2_HUMANASPP1_HUMANBioGRID23644657 details
SIAH2_HUMANASPP2_HUMANBioGRID23644657 details
SIAH2_HUMANSIAH2_HUMANBioGRID16899216 23695783 23891150 26160177 details
SIAH2_HUMANUB2D3_HUMANBioGRID23695783 23891150 30833558 details
SIAH2_HUMANXAF1_HUMANBioGRID25313037 details
SIAH2_HUMANAK1C3_HUMANBioGRID26160177 details
SIAH2_HUMANCHK2_HUMANBioGRID26751770 details
SIAH2_HUMANZYX_HUMANBioGRID27030211 details
SIAH2_HUMANUBE2N_HUMANBioGRID23695783 details
SIAH2_HUMANUB2V2_HUMANBioGRID23695783 details
SIAH2_HUMANNRF1_HUMANBioGRID30833558 details
SIAH2_HUMANOBF1_HUMANHPRD11483518 details
SIAH2_HUMANANDR_HUMANBioGRID, IntAct23518348 28549433 details
SIAH2_HUMANOPRK_HUMANBioGRID, IntAct23840749 details
SIAH2_HUMANLATS1_HUMANDIP25438054 details
SIAH2_HUMANAKAP1_HUMANBioGRID18323779 details
SIAH2_HUMANEGLN2_HUMANBioGRID15210114 16958618 details
SIAH2_HUMANEGLN1_HUMANBioGRID15210114 16958618 details
SIAH2_HUMANHDAC3_HUMANBioGRID20691163 details
SIAH2_HUMANSKI_HUMANBioGRID20691163 details
SIAH2_HUMANCEBPD_HUMANBioGRID22037769 details
SIAH2_HUMANPP1G_HUMANBioGRID17683050 details
SIAH2_HUMANKAT5_HUMANBioGRID23044042 details
SIAH2_HUMANKAT2B_HUMANBioGRID23044042 details
SIAH2_HUMANACK1_HUMANBioGRID23208506 details
SIAH2_HUMANNF2L2_HUMANBioGRID23645672 details
SIAH2_HUMANUB2L6_HUMANBioGRID, HPRD11786535 details
SIAH2_HUMANOPRD_HUMANBioGRID23840749 details
SIAH2_HUMANTYK2_HUMANBioGRID24833526 details
SIAH2_HUMANEAF2_HUMANBioGRID27058417 details
SIAH2_HUMANPLK3_HUMANBioGRID28515325 details
SIAH2_HUMANFLNC_HUMANBioGRID30063986 details
SIAH2_HUMANTES_HUMANBioGRID30063986 details
SIAH2_HUMANEP300_HUMANBioGRID30063986 details
SIAH2_HUMANPIWL2_HUMANBioGRID29555935 details
SIAH2_HUMANSENP7_HUMANBioGRID31825833 details
SIAH2_HUMANHMOX1_HUMANBioGRID32042051 details
SIAH2_HUMANBIP_HUMANBioGRID32206096 details
SIAH2_HUMANSYPH_HUMANHPRD11786535 details