Entity Details

Primary name UBP25_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UHP3
EntryNameUBP25_HUMAN
FullNameUbiquitin carboxyl-terminal hydrolase 25
TaxID9606
Evidenceevidence at protein level
Length1055
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesUSP25

GO terms

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GOName
GO:0004197 cysteine-type endopeptidase activity
GO:0004843 thiol-dependent deubiquitinase
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0006464 cellular protein modification process
GO:0006508 proteolysis
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008233 peptidase activity
GO:0016579 protein deubiquitination
GO:0019783 ubiquitin-like protein-specific protease activity
GO:0031625 ubiquitin protein ligase binding
GO:0032183 SUMO binding
GO:0043130 ubiquitin binding
GO:0051117 ATPase binding
GO:0070536 protein K63-linked deubiquitination
GO:0071108 protein K48-linked deubiquitination
GO:1904293 negative regulation of ERAD pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolaseDomainDomain
IPR003903 Ubiquitin interacting motifSiteConserved site
IPR009060 UBA-like superfamilyFamilyHomologous superfamily
IPR018200 Ubiquitin specific protease, conserved siteSiteConserved site
IPR028889 Ubiquitin specific protease domainDomainDomain
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily

Diseases

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Interactions

34 interactions

InteractorPartnerSourcesPublicationsLink
UBP25_HUMANSKIL_HUMANBioGRID, HPRD, MINT15231748 details
UBP25_HUMANKSYK_HUMANBioGRID, IntAct, MINT19909739 21516116 25416956 32296183 details
UBP25_HUMANTNKS2_HUMANBioGRID, IntAct22153077 28619731 details
UBP25_HUMANMAGB4_HUMANBioGRID, IntAct25416956 details
UBP25_HUMANRD23A_HUMANBioGRID, IntAct19013454 25416956 31515488 32296183 32814053 details
UBP25_HUMANSUMO2_HUMANBioGRID, IntAct18538659 25416956 28538147 32296183 details
UBP25_HUMANZN426_HUMANBioGRID, IntAct25416956 details
UBP25_HUMANRD23B_HUMANBioGRID, IntAct28514442 28619731 32296183 details
UBP25_HUMANTMM43_HUMANBioGRID, IntAct32296183 details
UBP25_HUMANTRIM1_HUMANBioGRID, IntAct32296183 details
UBP25_HUMANPUS10_HUMANBioGRID, IntAct32296183 details
UBP25_HUMANKAPCA_HUMANIntAct32814053 details
UBP25_HUMANTGFR2_HUMANIntAct32814053 details
UBP25_HUMANMT2_HUMANBioGRID16501887 details
UBP25_HUMANG3P_HUMANBioGRID16501887 details
UBP25_HUMANMYPC1_HUMANBioGRID16501887 details
UBP25_HUMANACTS_HUMANBioGRID16501887 details
UBP25_HUMANFLNC_HUMANBioGRID16501887 details
UBP25_HUMANUBP25_HUMANBioGRID19440361 30478318 30926242 30926243 details
UBP25_HUMANSUMO1_HUMANBioGRID18538659 28538147 details
UBP25_HUMANSUMO3_HUMANBioGRID18538659 details
UBP25_HUMANUBC9_HUMANBioGRID18538659 details
UBP25_HUMANUBC_HUMANBioGRID18538659 22195557 23314748 28190767 28327663 28538147 29131570 29576527 30926242 30926243 31699778 details
UBP25_HUMANSENP1_HUMANBioGRID18538659 details
UBP25_HUMANTNKS1_HUMANBioGRID28619731 30472184 details
UBP25_HUMANFXL17_HUMANBioGRID31560077 details
UBP25_HUMANTRAF6_HUMANInnateDB23042150 details
UBP25_HUMANTRAF5_HUMANInnateDB23042150 details
UBP25_HUMANKLH13_HUMANBioGRID19615732 28619731 details
UBP25_HUMANA4_HUMANBioGRID25740315 details
UBP25_HUMANASPC1_HUMANBioGRID29773651 details
UBP25_HUMANTRAF3_HUMANBioGRID30579117 details
UBP25_HUMANHDA11_HUMANBioGRID31746627 details
UBP25_HUMANCGAS_HUMANBioGRID32457395 details