Entity Details

Primary name CNOT7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UIV1
EntryNameCNOT7_HUMAN
FullNameCCR4-NOT transcription complex subunit 7
TaxID9606
Evidenceevidence at protein level
Length285
SequenceStatuscomplete
DateCreated2001-08-14
DateModified2021-06-02

Ontological Relatives

GenesCNOT7

GO terms

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GOName
GO:0000175 3'-5'-exoribonuclease activity
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0000932 P-body
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0004532 exoribonuclease activity
GO:0004535 poly(A)-specific ribonuclease activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0010629 negative regulation of gene expression
GO:0016020 membrane
GO:0016604 nuclear body
GO:0016607 nuclear speck
GO:0017148 negative regulation of translation
GO:0030014 CCR4-NOT complex
GO:0030015 CCR4-NOT core complex
GO:0031047 gene silencing by RNA
GO:0033962 P-body assembly
GO:0035195 gene silencing by miRNA
GO:0042509 regulation of tyrosine phosphorylation of STAT protein
GO:0043928 exonucleolytic catabolism of deadenylated mRNA
GO:0045070 positive regulation of viral genome replication
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0051607 defense response to virus
GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0061014 positive regulation of mRNA catabolic process
GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR006941 Ribonuclease CAF1FamilyFamily
IPR012337 Ribonuclease H-like superfamilyFamilyHomologous superfamily
IPR036397 Ribonuclease H superfamilyFamilyHomologous superfamily
IPR039636 CCR4-NOT transcription complex subunit 7FamilyFamily
IPR039637 CCR4-NOT transcription complex subunit 7/8/Pop2FamilyFamily

Diseases

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Interactions

60 interactions

InteractorPartnerSourcesPublicationsLink
CNOT7_HUMANTOB1_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10602502 11429045 18056425 18377426 19276069 20595394 21336257 26186194 28514442 31515488 details
CNOT7_HUMANCNO6L_HUMANBioGRID, DIP, IntAct, UniProt17452450 21984185 26186194 27173435 28514442 29395067 32296183 unassigned1312 details
CNOT7_HUMANARIP4_HUMANBioGRID, MINT21516116 26186194 29395067 details
CNOT7_HUMANSCAR3_HUMANBioGRID, MINT21516116 details
CNOT7_HUMANBTG1_HUMANBioGRID, HPRD, IntAct, MINT, UniProt11136725 11429045 21900206 27107012 29395067 30217970 9820826 details
CNOT7_HUMANNEMO_HUMANBioGRID, IntAct20098747 details
CNOT7_HUMANCNOT1_HUMANBioGRID, IntAct, UniProt21278420 22977175 26186194 26344197 26496610 28514442 29395067 details
CNOT7_HUMANTNR6A_HUMANBioGRID, UniProt21981923 21984185 28813667 29395067 details
CNOT7_HUMANCNOT6_HUMANIntAct, UniProt11747467 unassigned1312 details
CNOT7_HUMANBTG2_HUMANBioGRID, HPRD, IntAct, UniProt11136725 11429045 25416956 29395067 32296183 9712883 details
CNOT7_HUMANTOB2_HUMANBioGRID, HPRD, IntAct10602502 11429045 25416956 26186194 28514442 32296183 details
CNOT7_HUMANT11L1_HUMANBioGRID, IntAct32296183 details
CNOT7_HUMANHD_HUMANBioGRID, IntAct, UniProt25959826 32814053 details
CNOT7_HUMANHXD4_HUMANBioGRID, IntAct20211142 details
CNOT7_HUMANPABP1_HUMANBioGRID, HPRD18056425 29395067 details
CNOT7_HUMANCDK4_HUMANBioGRID, HPRD10602502 30217970 details
CNOT7_HUMANA4_HUMANBioGRID21832049 details
CNOT7_HUMANFOXC2_HUMANBioGRID25416956 details
CNOT7_HUMANFBX7_HUMANBioGRID27503909 details
CNOT7_HUMANLSM3_HUMANBioGRID30217970 details
CNOT7_HUMANNMI_HUMANBioGRID30217970 details
CNOT7_HUMANTS101_HUMANBioGRID30217970 details
CNOT7_HUMANSHLB2_HUMANBioGRID30217970 details
CNOT7_HUMANPRS4_HUMANBioGRID30217970 details
CNOT7_HUMANMR1L1_HUMANBioGRID30217970 details
CNOT7_HUMANPRS7_HUMANBioGRID30217970 details
CNOT7_HUMANTEX11_HUMANBioGRID30217970 details
CNOT7_HUMANPIAS1_HUMANBioGRID30217970 details
CNOT7_HUMANFHL3_HUMANBioGRID30217970 details
CNOT7_HUMANAGO2_HUMANBioGRID, UniProt19716330 21981923 29395067 details
CNOT7_HUMANTNR6C_HUMANBioGRID, DIP, UniProt21981923 21984185 29395067 details
CNOT7_HUMANTNR6B_HUMANBioGRID, UniProt21981923 29395067 details
CNOT7_HUMANSTAT1_HUMANMINT23386060 details
CNOT7_HUMANH31_HUMANIntAct24209620 details
CNOT7_HUMANCNOT2_HUMANBioGRID, IntAct26186194 27173435 28514442 29395067 unassigned1312 details
CNOT7_HUMANTB182_HUMANBioGRID, IntAct26186194 27173435 28514442 29395067 unassigned1312 details
CNOT7_HUMANNFKB1_HUMANBioGRID, IntAct27173435 unassigned1312 details
CNOT7_HUMANCNO11_HUMANBioGRID, IntAct26186194 27173435 28514442 29395067 unassigned1312 details
CNOT7_HUMANBTG3_HUMANBioGRID, HPRD, IntAct11429045 26186194 28514442 details
CNOT7_HUMANCDK2_HUMANBioGRID, HPRD10602502 details
CNOT7_HUMANCDK1_HUMANBioGRID, HPRD10602502 details
CNOT7_HUMANMEX3C_HUMANBioGRID26471122 details
CNOT7_HUMANRC3H1_HUMANBioGRID26170170 29395067 30209976 32460013 details
CNOT7_HUMANTTP_HUMANBioGRID21078877 29395067 details
CNOT7_HUMANZ3H7A_HUMANBioGRID29395067 30995489 details
CNOT7_HUMANPUM1_HUMANBioGRID29395067 details
CNOT7_HUMANOBI1_HUMANBioGRID29395067 details
CNOT7_HUMANSMG7_HUMANBioGRID29395067 details
CNOT7_HUMANYTHD2_HUMANBioGRID29395067 details
CNOT7_HUMANMEX3B_HUMANBioGRID29395067 details
CNOT7_HUMANPATL1_HUMANBioGRID29395067 details
CNOT7_HUMANPRC2A_HUMANBioGRID29395067 details
CNOT7_HUMANUNK_HUMANBioGRID29395067 details
CNOT7_HUMANYTHD3_HUMANBioGRID29395067 details
CNOT7_HUMANTOP3B_HUMANBioGRID29395067 details
CNOT7_HUMANRBMS1_HUMANBioGRID29395067 details
CNOT7_HUMANYTHD1_HUMANBioGRID29395067 details
CNOT7_HUMANR3HD2_HUMANBioGRID29395067 details
CNOT7_HUMANSMAG2_HUMANBioGRID29395067 details
CNOT7_HUMANCDK6_HUMANHPRD10602502 details