Entity Details

Primary name LEF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UJU2
EntryNameLEF1_HUMAN
FullNameLymphoid enhancer-binding factor 1
TaxID9606
Evidenceevidence at protein level
Length399
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesLEF1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001649 osteoblast differentiation
GO:0001756 somitogenesis
GO:0001837 epithelial to mesenchymal transition
GO:0002040 sprouting angiogenesis
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0008013 beta-catenin binding
GO:0008284 positive regulation of cell population proliferation
GO:0008301 DNA binding, bending
GO:0010628 positive regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0021542 dentate gyrus development
GO:0021861 forebrain radial glial cell differentiation
GO:0021873 forebrain neuroblast division
GO:0021943 formation of radial glial scaffolds
GO:0022408 negative regulation of cell-cell adhesion
GO:0022409 positive regulation of cell-cell adhesion
GO:0030111 regulation of Wnt signaling pathway
GO:0030223 neutrophil differentiation
GO:0030284 estrogen receptor activity
GO:0030326 embryonic limb morphogenesis
GO:0030331 estrogen receptor binding
GO:0030335 positive regulation of cell migration
GO:0030509 BMP signaling pathway
GO:0030851 granulocyte differentiation
GO:0030854 positive regulation of granulocyte differentiation
GO:0030879 mammary gland development
GO:0032696 negative regulation of interleukin-13 production
GO:0032713 negative regulation of interleukin-4 production
GO:0032714 negative regulation of interleukin-5 production
GO:0032993 protein-DNA complex
GO:0033153 T cell receptor V(D)J recombination
GO:0042100 B cell proliferation
GO:0042393 histone binding
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042826 histone deacetylase binding
GO:0043066 negative regulation of apoptotic process
GO:0043392 negative regulation of DNA binding
GO:0043565 sequence-specific DNA binding
GO:0043586 tongue development
GO:0043923 positive regulation by host of viral transcription
GO:0043966 histone H3 acetylation
GO:0043967 histone H4 acetylation
GO:0045063 T-helper 1 cell differentiation
GO:0045295 gamma-catenin binding
GO:0045588 positive regulation of gamma-delta T cell differentiation
GO:0045843 negative regulation of striated muscle tissue development
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048341 paraxial mesoderm formation
GO:0050909 sensory perception of taste
GO:0060033 anatomical structure regression
GO:0060070 canonical Wnt signaling pathway
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0060325 face morphogenesis
GO:0060326 cell chemotaxis
GO:0060710 chorio-allantoic fusion
GO:0061153 trachea gland development
GO:0062009 secondary palate development
GO:0070016 armadillo repeat domain binding
GO:0070742 C2H2 zinc finger domain binding
GO:0071345 cellular response to cytokine stimulus
GO:0071353 cellular response to interleukin-4
GO:0071864 positive regulation of cell proliferation in bone marrow
GO:0071866 negative regulation of apoptotic process in bone marrow cell
GO:0071899 obsolete negative regulation of estrogen receptor binding
GO:0090068 positive regulation of cell cycle process
GO:1902262 apoptotic process involved in blood vessel morphogenesis
GO:1904837 beta-catenin-TCF complex assembly
GO:1990837 sequence-specific double-stranded DNA binding
GO:1990907 beta-catenin-TCF complex

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR009071 High mobility group box domainDomainDomain
IPR013558 CTNNB1 binding, N-teminalDomainDomain
IPR024940 Transcription factor TCF/LEFFamilyFamily
IPR027397 Catenin binding domain superfamilyFamilyHomologous superfamily
IPR028769 Lymphoid enhancer-binding factor 1FamilyFamily
IPR036910 High mobility group box domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00903 Etacrynic acidDrugbanksmall molecule

Interactions

52 interactions

InteractorPartnerSourcesPublicationsLink
LEF1_HUMANTLE1_HUMANBioGRID, HPRD, IntAct15768032 9751710 details
LEF1_HUMANDPYL2_HUMANBioGRID, IntAct21988832 details
LEF1_HUMANCTNB1_HUMANbhf-ucl, BioGRID, DIP, HPRD, I2D, IntAct, Molecular Connections10890911 10958684 11751639 11835406 12077367 12556497 12748295 15525529 15684397 15728254 15768032 16204248 16510874 16510875 17510365 17517646 18077326 18296023 19223551 20123964 21743491 22014570 27684187 29374064 29540185 8757136 9419974 details
LEF1_HUMANAURKA_HUMANBioGRID, MINT24412244 details
LEF1_HUMANBAX_HUMANBioGRID, MINT24412244 details
LEF1_HUMANBUB1_HUMANBioGRID, MINT24412244 details
LEF1_HUMANMLH1_HUMANBioGRID, MINT24412244 details
LEF1_HUMANMLH3_HUMANBioGRID, MINT24412244 details
LEF1_HUMANMSH2_HUMANBioGRID, MINT24412244 details
LEF1_HUMANRASN_HUMANBioGRID, MINT24412244 details
LEF1_HUMANRB_HUMANBioGRID, MINT24412244 details
LEF1_HUMANSTK11_HUMANBioGRID, MINT24412244 details
LEF1_HUMANAF1Q_HUMANIntAct26079538 details
LEF1_HUMANNF2L2_HUMANIntAct32911434 details
LEF1_HUMANZBTB3_HUMANIntAct20211142 details
LEF1_HUMANPIAS4_HUMANBioGRID, HPRD11731474 details
LEF1_HUMANMITF_HUMANBioGRID, HPRD12032083 12048204 details
LEF1_HUMANEP300_HUMANBioGRID, HPRD12446687 details
LEF1_HUMANTHOC4_HUMANBioGRID, HPRD9119228 details
LEF1_HUMANNOTC1_HUMANBioGRID, HPRD11604490 details
LEF1_HUMANNLK_HUMANBioGRID, HPRD12556497 12901858 20194509 24394665 details
LEF1_HUMANSMAD2_HUMANBioGRID, HPRD10890911 15750622 details
LEF1_HUMANSMAD3_HUMANBioGRID, HPRD10890911 15750622 details
LEF1_HUMANSMAD4_HUMANBioGRID, HPRD10890911 details
LEF1_HUMANKMT5A_HUMANBioGRID21282610 details
LEF1_HUMANTLE2_HUMANBioGRID15768032 details
LEF1_HUMANCDX1_HUMANBioGRID, HPRD15143193 details
LEF1_HUMANPITX2_HUMANBioGRID, HPRD15728254 details
LEF1_HUMANRN138_HUMANBioGRID16714285 27195665 details
LEF1_HUMANIMA1_HUMANHPRD8631802 details
LEF1_HUMANIMA5_HUMANHPRD8631802 details
LEF1_HUMANTF7L2_HUMANBioGRID, IntAct22014570 24748645 details
LEF1_HUMANIGF1R_HUMANMINT22261717 details
LEF1_HUMANPLAK_HUMANbhf-ucl14661054 details
LEF1_HUMANFHIT_HUMANBioGRID, DIP18077326 details
LEF1_HUMANSMAD7_HUMANBioGRID15684397 15750622 details
LEF1_HUMANUBF1_HUMANBioGRID, HPRD12748295 details
LEF1_HUMANRUVB1_HUMANBioGRID9843967 details
LEF1_HUMANDAZP2_HUMANBioGRID19304756 details
LEF1_HUMANDACT1_HUMANBioGRID18936100 details
LEF1_HUMANHDAC1_HUMANBioGRID10958684 details
LEF1_HUMANE2F1_HUMANBioGRID17980157 details
LEF1_HUMANMYB_HUMANBioGRID21795403 details
LEF1_HUMANHINT1_HUMANBioGRID16014379 details
LEF1_HUMANSTA5A_HUMANBioGRID24394665 details
LEF1_HUMANNARF_HUMANBioGRID24394665 details
LEF1_HUMANRNF14_HUMANBioGRID23449499 details
LEF1_HUMANSMAD1_HUMANBioGRID, HPRD10890911 15750622 details
LEF1_HUMANPJA2_HUMANBioGRID30021253 details
LEF1_HUMANSUMO2_HUMANHPRD11731474 details
LEF1_HUMANRUNX2_HUMANHPRD12551949 details
LEF1_HUMANALX4_HUMANHPRD11696550 details