Entity Details

Primary name ACTN4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43707
EntryNameACTN4_HUMAN
FullNameAlpha-actinin-4
TaxID9606
Evidenceevidence at protein level
Length911
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesACTN4

GO terms

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GOName
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0001666 response to hypoxia
GO:0001725 stress fiber
GO:0001882 nucleoside binding
GO:0002576 platelet degranulation
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0003779 actin binding
GO:0005178 integrin binding
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0015031 protein transport
GO:0016604 nuclear body
GO:0030050 vesicle transport along actin filament
GO:0030335 positive regulation of cell migration
GO:0030374 nuclear receptor coactivator activity
GO:0031093 platelet alpha granule lumen
GO:0031143 pseudopodium
GO:0031490 chromatin DNA binding
GO:0032417 positive regulation of sodium:proton antiporter activity
GO:0032991 protein-containing complex
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0035357 peroxisome proliferator activated receptor signaling pathway
GO:0042803 protein homodimerization activity
GO:0042974 retinoic acid receptor binding
GO:0042981 regulation of apoptotic process
GO:0043005 neuron projection
GO:0044325 transmembrane transporter binding
GO:0047485 protein N-terminus binding
GO:0048384 retinoic acid receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0051015 actin filament binding
GO:0051272 positive regulation of cellular component movement
GO:0070062 extracellular exosome
GO:1900025 negative regulation of substrate adhesion-dependent cell spreading
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1903506 regulation of nucleic acid-templated transcription
GO:1990904 ribonucleoprotein complex

Subcellular Location

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Subcellular Location
Cell junction
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001589 Actinin-type actin-binding domain, conserved siteSiteConserved site
IPR001715 Calponin homology domainDomainDomain
IPR002017 Spectrin repeatRepeatRepeat
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR014837 EF-hand, Ca insensitiveDomainDomain
IPR018159 Spectrin/alpha-actininRepeatRepeat
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR036872 CH domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

80 interactions

InteractorPartnerSourcesPublicationsLink
ACTN4_HUMANMYOZ2_HUMANBioGRID, HPRD, IntAct16189514 19447967 25416956 25910212 26871637 32296183 details
ACTN4_HUMANMYOZ1_HUMANBioGRID, HPRD, IntAct16189514 details
ACTN4_HUMANPDLI1_HUMANBioGRID, HPRD, IntAct10753915 16189514 26186194 28514442 29892012 details
ACTN4_HUMANCOIL_HUMANBioGRID, HPRD, IntAct16713569 details
ACTN4_HUMANSACS_HUMANBioGRID, HPRD, IntAct16713569 details
ACTN4_HUMANCTNB1_HUMANBioGRID, IntAct16204054 25241761 details
ACTN4_HUMANCDN2A_HUMANBioGRID, IntAct17955473 details
ACTN4_HUMANNOS3_HUMANBioGRID, IntAct21163940 details
ACTN4_HUMANSTAT1_HUMANBioGRID, IntAct20936779 details
ACTN4_HUMANATX7_HUMANBioGRID, IntAct21078624 details
ACTN4_HUMANPOTE1_HUMANBioGRID, IntAct21988832 details
ACTN4_HUMANIMA1_HUMANBioGRID, IntAct21988832 details
ACTN4_HUMANMK07_HUMANBioGRID, IntAct21988832 details
ACTN4_HUMANRS27_HUMANBioGRID, IntAct21988832 details
ACTN4_HUMANTHIO_HUMANBioGRID, IntAct21988832 details
ACTN4_HUMANTITIN_HUMANBioGRID, IntAct23414517 details
ACTN4_HUMANHSPB1_HUMANBioGRID, IntAct25277244 details
ACTN4_HUMANAP2C_HUMANIntAct24835590 details
ACTN4_HUMANAP2A_HUMANIntAct24835590 details
ACTN4_HUMANEGFR_HUMANBioGRID, IntAct24658140 25402006 26320552 31980649 details
ACTN4_HUMANESR1_HUMANBioGRID, IntAct21078666 25604459 details
ACTN4_HUMANNHRF2_HUMANBioGRID, HPRD, IntAct11948184 27173435 unassigned1312 details
ACTN4_HUMANSCRIB_HUMANMINT24550280 details
ACTN4_HUMANCN119_HUMANBioGRID, IntAct32296183 details
ACTN4_HUMANMILK2_HUMANBioGRID, IntAct32296183 details
ACTN4_HUMANACTN3_HUMANBioGRID, HPRD, IntAct10656685 25416956 32296183 details
ACTN4_HUMANLNX1_HUMANBioGRID, IntAct32296183 details
ACTN4_HUMANSRBS2_HUMANBioGRID, IntAct25910212 details
ACTN4_HUMANTYW4_HUMANBioGRID, IntAct25910212 details
ACTN4_HUMANMEOX2_HUMANBioGRID, IntAct25910212 details
ACTN4_HUMANRARA_HUMANBioGRID, DIP22351778 details
ACTN4_HUMANPE2R4_HUMANBioGRID, MINT28298427 details
ACTN4_HUMANCOHA1_HUMANBioGRID, HPRD11739652 details
ACTN4_HUMANTRIM3_HUMANBioGRID, HPRD10673389 15772161 30542119 details
ACTN4_HUMANMAGI1_HUMANBioGRID, HPRD12042308 details
ACTN4_HUMANGELS_HUMANBioGRID, HPRD11733011 details
ACTN4_HUMANKCC2A_HUMANBioGRID11160423 details
ACTN4_HUMANKCC2B_HUMANBioGRID, HPRD11160423 details
ACTN4_HUMANINO80_HUMANBioGRID20197409 details
ACTN4_HUMANHDAC7_HUMANBioGRID16980305 details
ACTN4_HUMANMEF2A_HUMANBioGRID16980305 details
ACTN4_HUMANUCHL5_HUMANBioGRID21800051 details
ACTN4_HUMANVDR_HUMANBioGRID21078666 details
ACTN4_HUMANHGS_HUMANBioGRID15772161 22863883 26819309 details
ACTN4_HUMANARF_HUMANBioGRID17955473 details
ACTN4_HUMANBMP7_HUMANBioGRID25416956 details
ACTN4_HUMANDDIAS_HUMANBioGRID28079882 details
ACTN4_HUMANTRI23_HUMANBioGRID26871637 details
ACTN4_HUMANLRRC7_HUMANHPRD11160423 details
ACTN4_HUMANAA2AR_HUMANHPRD12837758 details
ACTN4_HUMANPAI1_HUMANHPRD15493875 details
ACTN4_HUMANM3K3_HUMANIntAct14743216 details
ACTN4_HUMANRIPK3_HUMANIntAct14743216 details
ACTN4_HUMAN1433Z_HUMANMINT15161933 details
ACTN4_HUMANZO1_HUMANBioGRID, HPRD, IntAct16944923 details
ACTN4_HUMANIQGA1_HUMANBioGRID, IntAct22662192 26496610 details
ACTN4_HUMANPPARG_HUMANDIP22351778 details
ACTN4_HUMANACTN4_HUMANDIP22351778 details
ACTN4_HUMANUS6NL_HUMANBioGRID, HPRD15152255 details
ACTN4_HUMANUBF1_HUMANBioGRID20197409 details
ACTN4_HUMANHDAC5_HUMANBioGRID21081666 details
ACTN4_HUMANGLUT4_HUMANBioGRID, HPRD16396496 details
ACTN4_HUMANISG15_HUMANBioGRID16009940 33024031 details
ACTN4_HUMANITA4_HUMANBioGRID22623428 details
ACTN4_HUMANSVIL_HUMANBioGRID, HPRD12202484 details
ACTN4_HUMANGBB2_HUMANBioGRID23326349 details
ACTN4_HUMANNFYA_HUMANBioGRID15364540 details
ACTN4_HUMANACTS_HUMANBioGRID19920151 details
ACTN4_HUMANCDK9_HUMANBioGRID26209609 details
ACTN4_HUMANACTC_HUMANBioGRID, HPRD12042308 30890647 details
ACTN4_HUMANTF65_HUMANBioGRID30542119 details
ACTN4_HUMANANM5_HUMANBioGRID30542119 details
ACTN4_HUMANNMDZ1_HUMANBioGRID16510730 details
ACTN4_HUMANRGS9_HUMANBioGRID16510730 details
ACTN4_HUMANSOX2_HUMANBioGRID21280222 details
ACTN4_HUMANPTN11_HUMANHPRD11382784 details
ACTN4_HUMANVATB1_HUMANHPRD10915794 details
ACTN4_HUMANPTN6_HUMANHPRD15070900 15588985 details
ACTN4_HUMANNEBU_HUMANHPRD11882289 details
ACTN4_HUMANNOS2_HUMANHPRD12960352 details