Entity Details

Primary name DICER_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UPY3
EntryNameDICER_HUMAN
FullNameEndoribonuclease Dicer
TaxID9606
Evidenceevidence at protein level
Length1922
SequenceStatuscomplete
DateCreated2002-10-25
DateModified2021-06-02

Ontological Relatives

GenesDICER1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0004386 helicase activity
GO:0004521 endoribonuclease activity
GO:0004525 ribonuclease III activity
GO:0004530 deoxyribonuclease I activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005829 cytosol
GO:0006309 apoptotic DNA fragmentation
GO:0010586 miRNA metabolic process
GO:0010626 negative regulation of Schwann cell proliferation
GO:0010629 negative regulation of gene expression
GO:0014040 positive regulation of Schwann cell differentiation
GO:0016032 viral process
GO:0016442 RISC complex
GO:0019904 protein domain specific binding
GO:0021675 nerve development
GO:0030422 production of siRNA involved in RNA interference
GO:0030423 targeting of mRNA for destruction involved in RNA interference
GO:0030425 dendrite
GO:0030426 growth cone
GO:0031054 pre-miRNA processing
GO:0031643 positive regulation of myelination
GO:0032290 peripheral nervous system myelin formation
GO:0032720 negative regulation of tumor necrosis factor production
GO:0033167 ARC complex
GO:0033168 conversion of ds siRNA to ss siRNA involved in RNA interference
GO:0035087 siRNA loading onto RISC involved in RNA interference
GO:0035196 production of miRNAs involved in gene silencing by miRNA
GO:0035197 siRNA binding
GO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA
GO:0036404 conversion of ds siRNA to ss siRNA
GO:0038061 NIK/NF-kappaB signaling
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm
GO:0048812 neuron projection morphogenesis
GO:0070062 extracellular exosome
GO:0070578 RISC-loading complex
GO:0070883 pre-miRNA binding
GO:0090501 RNA phosphodiester bond hydrolysis
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000999 Ribonuclease III domainDomainDomain
IPR001650 Helicase, C-terminalDomainDomain
IPR003100 PAZ domainDomainDomain
IPR005034 Dicer dimerisation domainDomainDomain
IPR006935 Helicase/UvrB, N-terminalDomainDomain
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR014720 Double-stranded RNA-binding domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036085 PAZ domain superfamilyFamilyHomologous superfamily
IPR036389 Ribonuclease III, endonuclease domain superfamilyFamilyHomologous superfamily
IPR038248 Dicer dimerisation domain superfamilyFamilyHomologous superfamily
IPR044441 Dicer, double-stranded RNA-binding domainDomainDomain

Diseases

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Interactions

30 interactions

InteractorPartnerSourcesPublicationsLink
DICER_HUMANPIWL1_HUMANBioGRID, HPRD, UniProt14749716 details
DICER_HUMANAGO2_HUMANbhf-ucl, BioGRID, DIP, HPRD, IntAct, MINT, UniProt12526743 14749716 16357216 17932509 18178619 19716330 19820710 19955415 21858095 22484317 23143396 23622242 23636329 23661684 23741051 24778252 25446899 26496610 29395067 details
DICER_HUMANPIWL4_HUMANBioGRID, HPRD, UniProt12906857 14749716 details
DICER_HUMANPRKRA_HUMANbhf-ucl, BioGRID, HPRD, IntAct, MINT16424907 21858095 23661684 24778252 details
DICER_HUMANTRBP2_HUMANbhf-ucl, BioGRID, DIP, HPRD, IntAct, MINT15973356 16142218 16424907 19668211 19804757 19820710 19836333 21858095 23622242 23661684 24778252 25446899 28174252 33328224 details
DICER_HUMANAAKB2_HUMANBioGRID, IntAct21988832 details
DICER_HUMANDHX58_HUMANBioGRID, IntAct21903422 details
DICER_HUMANE2AK2_HUMANBioGRID, IntAct21903422 details
DICER_HUMANTNF12_HUMANIntAct29657270 details
DICER_HUMANLOX5_HUMANBioGRID10051563 19022417 details
DICER_HUMANAGO1_HUMANBioGRID, HPRD, MINT, UniProt12526743 12906857 17932509 19716330 24778252 details
DICER_HUMANGEMI4_HUMANBioGRID, IntAct23143396 23752268 details
DICER_HUMANDSRAD_HUMANIntAct23622242 details
DICER_HUMANAGO3_HUMANBioGRID, IntAct12906857 24778252 26496610 details
DICER_HUMANCFA20_HUMANBioGRID, IntAct27173435 unassigned1312 details
DICER_HUMANFXL14_HUMANBioGRID, IntAct24035498 28514442 details
DICER_HUMANFUBP2_HUMANDIP, IntAct19458619 21858095 details
DICER_HUMANRPB1_HUMANDIP24814348 details
DICER_HUMANNU153_HUMANIntAct21858095 details
DICER_HUMANDHX9_HUMANBioGRID, IntAct17531811 21858095 details
DICER_HUMANAGO4_HUMANBioGRID12906857 details
DICER_HUMANPIWL3_HUMANBioGRID12906857 details
DICER_HUMANPIWL2_HUMANBioGRID, HPRD12906857 details
DICER_HUMANCACO2_HUMANBioGRID23143396 details
DICER_HUMANSMN_HUMANBioGRID23752268 details
DICER_HUMANDICER_HUMANBioGRID23752268 details
DICER_HUMANCUL4A_HUMANBioGRID23849790 details
DICER_HUMANLIN41_HUMANBioGRID24602972 details
DICER_HUMANSTAU1_HUMANBioGRID29395067 30948266 details
DICER_HUMANTULP3_HUMANBioGRID33187986 details