Entity Details

Primary name KCC2A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UQM7
EntryNameKCC2A_HUMAN
FullNameCalcium/calmodulin-dependent protein kinase type II subunit alpha
TaxID9606
Evidenceevidence at protein level
Length478
SequenceStatuscomplete
DateCreated2002-04-16
DateModified2021-06-02

Ontological Relatives

GenesCAMK2A

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000165 MAPK cascade
GO:0002931 response to ischemia
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005954 calcium- and calmodulin-dependent protein kinase complex
GO:0006468 protein phosphorylation
GO:0006816 calcium ion transport
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0009931 calcium-dependent protein serine/threonine kinase activity
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0014069 postsynaptic density
GO:0016301 kinase activity
GO:0018105 peptidyl-serine phosphorylation
GO:0030666 endocytic vesicle membrane
GO:0035254 glutamate receptor binding
GO:0038166 angiotensin-activated signaling pathway
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043005 neuron projection
GO:0043197 dendritic spine
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0046928 regulation of neurotransmitter secretion
GO:0048168 regulation of neuronal synaptic plasticity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051346 negative regulation of hydrolase activity
GO:0051928 positive regulation of calcium ion transport
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060996 dendritic spine development
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900034 regulation of cellular response to heat
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1990443 peptidyl-threonine autophosphorylation
GO:2000124 regulation of endocannabinoid signaling pathway
GO:2000310 regulation of NMDA receptor activity
GO:2001222 regulation of neuron migration

Subcellular Location

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Subcellular Location
Cell junction
Cell projection

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domainDomainDomain
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR032710 NTF2-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB04119 Hexatantalum DodecabromideDrugbanksmall molecule
DB04447 1,4-DithiothreitolDrugbanksmall molecule
DB07766 (2Z,3E)-2,3'-biindole-2',3(1H,1'H)-dione 3-{O-[(3R)-3,4-dihydroxybutyl]oxime}Drugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

115 interactions

InteractorPartnerSourcesPublicationsLink
KCC2A_HUMANGRIA4_HUMANMINT10366608 details
KCC2A_HUMANACTN1_HUMANBioGRID, IntAct, MINT12223541 25241761 details
KCC2A_HUMANCALM2_HUMANBioGRID, DIP, IntAct17353931 20668654 details
KCC2A_HUMANKCC2D_HUMANBioGRID, DIP, IntAct17353931 20668654 25852190 28514442 29426014 31980649 32296183 details
KCC2A_HUMANKCC2B_HUMANBioGRID, IntAct17353931 27173435 29426014 32296183 unassigned1312 details
KCC2A_HUMANZN363_HUMANBioGRID, MINT17568776 details
KCC2A_HUMANKCC2A_HUMANBioGRID, DIP, IntAct11559703 20668654 21884935 31980649 details
KCC2A_HUMANPPM1F_HUMANBioGRID, MINT11559703 details
KCC2A_HUMANNMDE2_HUMANBioGRID, MINT11459059 16436603 19453375 9694809 details
KCC2A_HUMANKCC2G_HUMANBioGRID, IntAct25852190 31980649 32296183 details
KCC2A_HUMANRM11_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANRHXF2_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANGLBL2_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANTEX37_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANKR151_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANSYVC_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANKR231_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANRALYL_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANKR193_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANK2C75_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANRBPMS_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANK22O_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANCA094_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANKR197_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANDAZP2_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANTTC5_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANSUOX_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANHYAL3_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANKRA81_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANARI5A_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANKRA61_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANLENG8_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANSOX5_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANRFOX2_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANNTAQ1_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANF168A_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANTCAF1_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANRBPS2_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANTSR2_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANAP2D_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANTAB2_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANKRA62_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANF168B_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANKR195_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANLASP1_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANTIAR_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANRBM47_HUMANBioGRID, IntAct32296183 details
KCC2A_HUMANCDC37_HUMANBioGRID, IntAct31980649 32296183 details
KCC2A_HUMANTRI63_HUMANBioGRID, IntAct31391242 details
KCC2A_HUMANTRI55_HUMANBioGRID, IntAct31391242 details
KCC2A_HUMANHS90A_HUMANBioGRID, IntAct22939624 31980649 32814053 details
KCC2A_HUMANACTS_HUMANIntAct32814053 details
KCC2A_HUMANAKT1_HUMANBioGRID, IntAct16027165 32814053 details
KCC2A_HUMANAPBB2_HUMANIntAct32814053 details
KCC2A_HUMANAT1A3_HUMANIntAct32814053 details
KCC2A_HUMANBDNF_HUMANIntAct32814053 details
KCC2A_HUMANVPS29_HUMANIntAct32814053 details
KCC2A_HUMANJIP2_HUMANIntAct32814053 details
KCC2A_HUMANUT14A_HUMANIntAct32814053 details
KCC2A_HUMANTOM1_HUMANIntAct32814053 details
KCC2A_HUMANPLPP1_HUMANIntAct32814053 details
KCC2A_HUMANUNG_HUMANIntAct32814053 details
KCC2A_HUMANSHC1_HUMANIntAct32814053 details
KCC2A_HUMANPNPH_HUMANIntAct32814053 details
KCC2A_HUMANNBL1_HUMANIntAct32814053 details
KCC2A_HUMANSMAD3_HUMANIntAct32814053 details
KCC2A_HUMANCBSL_HUMANIntAct32814053 details
KCC2A_HUMANG3P_HUMANIntAct32814053 details
KCC2A_HUMANUBE2K_HUMANIntAct32814053 details
KCC2A_HUMANPECA1_HUMANIntAct32814053 details
KCC2A_HUMANP85A_HUMANIntAct32814053 details
KCC2A_HUMANKPCB_HUMANIntAct32814053 details
KCC2A_HUMANRAB5A_HUMANIntAct32814053 details
KCC2A_HUMANS100B_HUMANIntAct32814053 details
KCC2A_HUMANVIME_HUMANIntAct32814053 details
KCC2A_HUMANCHIP_HUMANIntAct32814053 details
KCC2A_HUMANA4_HUMANIntAct32814053 details
KCC2A_HUMANDLG1_HUMANBioGRID12933808 details
KCC2A_HUMANRIMS1_HUMANBioGRID12871946 details
KCC2A_HUMANATF1_HUMANBioGRID8663317 details
KCC2A_HUMANCREB1_HUMANBioGRID8663317 details
KCC2A_HUMANCD5R1_HUMANBioGRID12223541 details
KCC2A_HUMANACTN4_HUMANBioGRID11160423 details
KCC2A_HUMAN1433B_HUMANBioGRID12619878 details
KCC2A_HUMANPRS8_HUMANBioGRID22496558 details
KCC2A_HUMANTAU_HUMANBioGRID17045592 17512525 details
KCC2A_HUMANSQSTM_HUMANBioGRID14702098 details
KCC2A_HUMANITA2B_HUMANBioGRID1650365 details
KCC2A_HUMANPTTG1_HUMANBioGRID24781523 details
KCC2A_HUMANZBT32_HUMANBioGRID32296183 details
KCC2A_HUMANKR221_HUMANBioGRID32296183 details
KCC2A_HUMANGRIA1_HUMANBioGRID24706758 details
KCC2A_HUMANNR2F6_HUMANIntAct20195357 details
KCC2A_HUMANHS90B_HUMANBioGRID, IntAct22939624 31980649 details
KCC2A_HUMANSSBP2_HUMANBioGRID, IntAct27173435 unassigned1312 details
KCC2A_HUMANNINL_HUMANBioGRID, IntAct26485645 27173435 unassigned1312 details
KCC2A_HUMANARL3_HUMANBioGRID, IntAct27173435 unassigned1312 details
KCC2A_HUMANDCTN2_HUMANBioGRID, IntAct27173435 unassigned1312 details
KCC2A_HUMANDCTN1_HUMANBioGRID, IntAct27173435 unassigned1312 details
KCC2A_HUMANDBNL_HUMANBioGRID, IntAct29426014 details
KCC2A_HUMANFAK2_HUMANIntAct31413325 details
KCC2A_HUMANFMR1_HUMANIntAct31413325 details
KCC2A_HUMANFXR1_HUMANMINT21653829 details
KCC2A_HUMANPRKN_HUMANBioGRID11679592 details
KCC2A_HUMANHDAC5_HUMANBioGRID18292392 details
KCC2A_HUMANGIT1_HUMANBioGRID18292392 details
KCC2A_HUMAN1433T_HUMANBioGRID18292392 details
KCC2A_HUMANPLCG1_HUMANBioGRID18292392 details
KCC2A_HUMANNOS3_HUMANBioGRID11397791 details
KCC2A_HUMANKCNC1_HUMANBioGRID19213956 details
KCC2A_HUMANSC6A3_HUMANBioGRID22514303 details
KCC2A_HUMANRD23A_HUMANBioGRID23260144 details
KCC2A_HUMANFKBP8_HUMANBioGRID15757646 details
KCC2A_HUMANCYLD_HUMANBioGRID24614225 details
KCC2A_HUMANNMDZ1_HUMANBioGRID9694809 details