Search
News
Downloads
About
Help
Contact
Entity Details
Primary name
M4K5_HUMAN
Entity type
UniProt
Source
Source Link
Details
Accession
Q9Y4K4
EntryName
M4K5_HUMAN
FullName
Mitogen-activated protein kinase kinase kinase kinase 5
TaxID
9606
Evidence
evidence at protein level
Length
846
SequenceStatus
complete
DateCreated
2003-04-30
DateModified
2021-06-02
Ontological Relatives
Genes
MAP4K5
GO terms
Show/Hide Table
GO
Name
GO:0004672
protein kinase activity
GO:0004674
protein serine/threonine kinase activity
GO:0005524
ATP binding
GO:0005737
cytoplasm
GO:0006468
protein phosphorylation
GO:0007257
obsolete activation of JUN kinase activity
GO:0008349
MAP kinase kinase kinase kinase activity
GO:0035556
intracellular signal transduction
GO:0106310
protein serine kinase activity
GO:0106311
protein threonine kinase activity
Subcellular Location
Show/Hide Table
Subcellular Location
Cytoplasm
Domains
Show/Hide Table
Domain
Name
Category
Type
IPR000719
Protein kinase domain
Domain
Domain
IPR001180
Citron homology (CNH) domain
Domain
Domain
IPR011009
Protein kinase-like domain superfamily
Family
Homologous superfamily
IPR017441
Protein kinase, ATP binding site
Site
Binding site
IPR021160
Mitogen-activated protein (MAP) kinase kinase kinase kinase
Family
Family
Diseases
Show/Hide Table
Drugs
Show/Hide Table
Drug
Name
Source
Type
DB12010
Fostamatinib
Drugbank
small molecule
Interactions
15 interactions
Interactor
Partner
Sources
Publications
Link
M4K5_HUMAN
CRKL_HUMAN
BioGRID, HPRD, IntAct
10648385
9788432
details
M4K5_HUMAN
GRB2_HUMAN
BioGRID, HPRD, IntAct
17474147
20936779
21706016
28514442
9788432
details
M4K5_HUMAN
FYN_HUMAN
IntAct
17474147
details
M4K5_HUMAN
NCK1_HUMAN
IntAct
17474147
details
M4K5_HUMAN
CSN5_HUMAN
BioGRID, IntAct
20936779
details
M4K5_HUMAN
HCK_HUMAN
BioGRID, IntAct
20936779
details
M4K5_HUMAN
ZN440_HUMAN
BioGRID, IntAct
20936779
details
M4K5_HUMAN
SETB1_HUMAN
BioGRID, MINT
21900206
details
M4K5_HUMAN
NEDD4_HUMAN
BioGRID
19953087
details
M4K5_HUMAN
SMUF1_HUMAN
BioGRID
20804422
details
M4K5_HUMAN
CRK_HUMAN
BioGRID, HPRD, IntAct
10648385
19380743
9788432
details
M4K5_HUMAN
TRAF2_HUMAN
BioGRID, HPRD
10477597
details
M4K5_HUMAN
ABL1_HUMAN
HPRD
9949177
details
M4K5_HUMAN
TANK_HUMAN
HPRD
10490605
details
M4K5_HUMAN
BCR_HUMAN
HPRD
9949177
details
This website requires cookies in order to function. By using the site you are agreeing to this as outlined in our
Terms of Use
I Agree