Entity Details

Primary name IRAK3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y616
EntryNameIRAK3_HUMAN
FullNameInterleukin-1 receptor-associated kinase 3
TaxID9606
Evidenceevidence at protein level
Length596
SequenceStatuscomplete
DateCreated2004-11-09
DateModified2021-06-02

Ontological Relatives

GenesIRAK3

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0009615 response to virus
GO:0010933 positive regulation of macrophage tolerance induction
GO:0010936 negative regulation of macrophage cytokine production
GO:0019221 cytokine-mediated signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032494 response to peptidoglycan
GO:0032496 response to lipopolysaccharide
GO:0032695 negative regulation of interleukin-12 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0035556 intracellular signal transduction
GO:0042177 negative regulation of protein catabolic process
GO:0042803 protein homodimerization activity
GO:0043242 negative regulation of protein-containing complex disassembly
GO:0043244 regulation of protein-containing complex disassembly
GO:0043330 response to exogenous dsRNA
GO:0043407 negative regulation of MAP kinase activity
GO:0045824 negative regulation of innate immune response
GO:0046777 protein autophosphorylation
GO:0046982 protein heterodimerization activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070555 response to interleukin-1
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000488 Death domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR033610 Interleukin-1 receptor-associated kinase 3FamilyFamily
IPR042698 Interleukin-1 receptor-associated kinase 3, pseudokinase domainDomainDomain
IPR042747 IRAK3, death domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule