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Entity Details
Primary name
ORC4_HUMAN
Entity type
UniProt
Source
Source Link
Details
Accession
O43929
EntryName
ORC4_HUMAN
FullName
Origin recognition complex subunit 4
TaxID
9606
Evidence
evidence at protein level
Length
436
SequenceStatus
complete
DateCreated
1999-07-15
DateModified
2021-06-02
Ontological Relatives
Genes
ORC4
GO terms
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GO
Name
GO:0000166
nucleotide binding
GO:0000781
chromosome, telomeric region
GO:0000808
origin recognition complex
GO:0003688
DNA replication origin binding
GO:0005524
ATP binding
GO:0005634
nucleus
GO:0005654
nucleoplasm
GO:0005664
nuclear origin of replication recognition complex
GO:0005730
nucleolus
GO:0005829
cytosol
GO:0006260
DNA replication
GO:0006270
DNA replication initiation
GO:0036388
pre-replicative complex assembly
Subcellular Location
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Subcellular Location
Nucleus
Domains
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Domain
Name
Category
Type
IPR003593
AAA+ ATPase domain
Domain
Domain
IPR016527
Origin recognition complex subunit 4
Family
Family
IPR027417
P-loop containing nucleoside triphosphate hydrolase
Family
Homologous superfamily
IPR032705
Origin recognition complex subunit 4, C-terminal
Domain
Domain
IPR041664
Orc1-like, AAA ATPase domain
Domain
Domain
Diseases
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Drugs
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Interactions
33 interactions
Interactor
Partner
Sources
Publications
Link
ORC4_HUMAN
MCM7_HUMAN
BioGRID, HPRD, IntAct
15232106
details
ORC4_HUMAN
ORC6_HUMAN
BioGRID, DIP, HPRD, IntAct
12614612
15232106
15910003
18234858
details
ORC4_HUMAN
MCM10_HUMAN
BioGRID, HPRD, IntAct
15232106
details
ORC4_HUMAN
CCND1_HUMAN
BioGRID, HPRD, IntAct
15232106
details
ORC4_HUMAN
MCM3_HUMAN
BioGRID, HPRD, IntAct
12614612
15232106
details
ORC4_HUMAN
ORC5_HUMAN
BioGRID, HPRD, IntAct
11395502
12614612
15232106
17716973
26264872
9765232
details
ORC4_HUMAN
CDN2A_HUMAN
BioGRID, IntAct
15232106
details
ORC4_HUMAN
ORC3_HUMAN
BioGRID, HPRD, IntAct
10402192
11323433
11395502
15232106
15910003
17716973
details
ORC4_HUMAN
ORC2_HUMAN
BioGRID, DIP, HPRD, IntAct
11323433
11395502
12004060
12614612
15232106
15910003
16549788
17716973
20850016
31160578
31467278
9353276
details
ORC4_HUMAN
CTBP1_HUMAN
BioGRID, IntAct
21988832
details
ORC4_HUMAN
IMA5_HUMAN
BioGRID, IntAct
21988832
details
ORC4_HUMAN
MLH1_HUMAN
BioGRID, IntAct
21988832
details
ORC4_HUMAN
FBXL5_HUMAN
BioGRID, IntAct
21988832
details
ORC4_HUMAN
FBX25_HUMAN
BioGRID, IntAct
21988832
details
ORC4_HUMAN
FBX6_HUMAN
BioGRID, IntAct
21988832
details
ORC4_HUMAN
FBXL8_HUMAN
BioGRID, IntAct
21988832
details
ORC4_HUMAN
MTUS1_HUMAN
BioGRID, IntAct
21988832
details
ORC4_HUMAN
ORC1_HUMAN
BioGRID, DIP, IntAct
12614612
16549788
17716973
26496610
31160578
details
ORC4_HUMAN
ITF2_HUMAN
BioGRID, IntAct
25416956
details
ORC4_HUMAN
RIR2B_HUMAN
BioGRID, IntAct
25416956
details
ORC4_HUMAN
RDH5_HUMAN
BioGRID, IntAct
27107012
details
ORC4_HUMAN
MCM2_HUMAN
BioGRID, HPRD
12614612
details
ORC4_HUMAN
MCM4_HUMAN
BioGRID
12614612
details
ORC4_HUMAN
MCM6_HUMAN
BioGRID
12614612
details
ORC4_HUMAN
RFA2_HUMAN
BioGRID
12614612
details
ORC4_HUMAN
A4_HUMAN
BioGRID
21832049
details
ORC4_HUMAN
ARF_HUMAN
BioGRID, HPRD
15232106
details
ORC4_HUMAN
H31T_HUMAN
BioGRID
20850016
details
ORC4_HUMAN
H4_HUMAN
BioGRID
20850016
details
ORC4_HUMAN
LRWD1_HUMAN
BioGRID, IntAct
26496610
31160578
details
ORC4_HUMAN
CCL2_HUMAN
BioGRID
21383955
details
ORC4_HUMAN
XRCC5_HUMAN
BioGRID
15910003
details
ORC4_HUMAN
XRCC6_HUMAN
BioGRID
15910003
details
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