Entity Details

Primary name AK1BA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO60218
EntryNameAK1BA_HUMAN
FullNameAldo-keto reductase family 1 member B10
TaxID9606
Evidenceevidence at protein level
Length316
SequenceStatuscomplete
DateCreated2002-05-10
DateModified2021-06-02

Ontological Relatives

GenesAKR1B10

GO terms

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GOName
GO:0001523 retinoid metabolic process
GO:0001758 retinal dehydrogenase activity
GO:0004032 alditol:NADP+ 1-oxidoreductase activity
GO:0004033 aldo-keto reductase (NADP) activity
GO:0005576 extracellular region
GO:0005739 mitochondrion
GO:0005764 lysosome
GO:0005829 cytosol
GO:0008106 alcohol dehydrogenase (NADP+) activity
GO:0016488 farnesol catabolic process
GO:0044597 daunorubicin metabolic process
GO:0044598 doxorubicin metabolic process
GO:0045550 geranylgeranyl reductase activity
GO:0047655 allyl-alcohol dehydrogenase activity
GO:0047718 indanol dehydrogenase activity
GO:0047834 D-threo-aldose 1-dehydrogenase activity
GO:0052650 NADP-retinol dehydrogenase activity
GO:0110095 cellular detoxification of aldehyde

Subcellular Location

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Subcellular Location
Lysosome
Secreted

Domains

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DomainNameCategoryType
IPR018170 Aldo/keto reductase, conserved siteSiteConserved site
IPR020471 Aldo-keto reductaseFamilyFamily
IPR023210 NADP-dependent oxidoreductase domainDomainDomain
IPR036812 NADP-dependent oxidoreductase domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00605 SulindacDrugbanksmall molecule
DB02021 FidarestatDrugbanksmall molecule
DB02383 TolrestatDrugbanksmall molecule
DB03461 Nicotinamide adenine dinucleotide phosphateDrugbanksmall molecule
DB06077 LumateperoneDrugbanksmall molecule
DB06246 ExisulindDrugbanksmall molecule
DB08772 ZopolrestatDrugbanksmall molecule

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
AK1BA_HUMANTE2IP_HUMANbhf-ucl, BioGRID21044950 details
AK1BA_HUMANACACA_HUMANBioGRID, IntAct18056116 details
AK1BA_HUMANISG15_HUMANBioGRID33024031 details