Entity Details

Primary name SASH1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO94885
EntryNameSASH1_HUMAN
FullNameSAM and SH3 domain-containing protein 1
TaxID9606
Evidenceevidence at protein level
Length1247
SequenceStatuscomplete
DateCreated2003-08-15
DateModified2021-06-02

Ontological Relatives

GenesSASH1

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0001965 G-protein alpha-subunit binding
GO:0005737 cytoplasm
GO:0008022 protein C-terminus binding
GO:0010595 positive regulation of endothelial cell migration
GO:0010632 regulation of epithelial cell migration
GO:0019901 protein kinase binding
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0032991 protein-containing complex
GO:0043507 positive regulation of JUN kinase activity
GO:0045766 positive regulation of angiogenesis
GO:0060090 molecular adaptor activity
GO:1900044 regulation of protein K63-linked ubiquitination
GO:1900745 positive regulation of p38MAPK cascade
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1902498 regulation of protein autoubiquitination

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001452 SH3 domainDomainDomain
IPR001660 Sterile alpha motif domainDomainDomain
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR021090 SAM/SH3 domain-containingFamilyFamily
IPR035720 SAM and SH3 domain-containing protein 1, SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR037627 SASH1, SAM domain repeat 1DomainDomain
IPR037630 SASH1, SAM domain repeat 2DomainDomain

Diseases

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Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
SASH1_HUMANSKIL_HUMANBioGRID, MINT15231748 details
SASH1_HUMANNCK1_HUMANIntAct17474147 details
SASH1_HUMANMED28_HUMANMINT16964398 details
SASH1_HUMANHD_HUMANIntAct17500595 details
SASH1_HUMANKHDR1_HUMANBioGRID22745667 details
SASH1_HUMANIKKB_HUMANBioGRID23776175 30480076 details
SASH1_HUMANAFF1_HUMANBioGRID30480076 details
SASH1_HUMANAKA10_HUMANBioGRID30480076 details
SASH1_HUMANARRB1_HUMANBioGRID30480076 details
SASH1_HUMANASCC2_HUMANBioGRID30480076 details
SASH1_HUMANC1D_HUMANBioGRID30480076 details
SASH1_HUMANCCDB1_HUMANBioGRID30480076 details
SASH1_HUMANCNKR1_HUMANBioGRID30480076 details
SASH1_HUMANCRK_HUMANBioGRID30480076 details
SASH1_HUMANCRKL_HUMANBioGRID30480076 details
SASH1_HUMANCTNA1_HUMANBioGRID30480076 details
SASH1_HUMANES8L2_HUMANBioGRID30480076 details
SASH1_HUMANJADE2_HUMANBioGRID30480076 details
SASH1_HUMANJADE3_HUMANBioGRID30480076 details
SASH1_HUMANKIF3B_HUMANBioGRID30480076 details
SASH1_HUMANMCRS1_HUMANBioGRID30480076 details
SASH1_HUMANOAS2_HUMANBioGRID30480076 details
SASH1_HUMANPP4R1_HUMANBioGRID30480076 details
SASH1_HUMANRB12B_HUMANBioGRID30480076 details
SASH1_HUMANSBP2L_HUMANBioGRID30480076 details
SASH1_HUMANSNX1_HUMANBioGRID30480076 details
SASH1_HUMANSPG7_HUMANBioGRID30480076 details
SASH1_HUMANSPTB2_HUMANBioGRID30480076 details
SASH1_HUMANSYNE2_HUMANBioGRID30480076 details
SASH1_HUMANTNKS2_HUMANBioGRID30480076 details
SASH1_HUMANUTRN_HUMANBioGRID30480076 details
SASH1_HUMANEXOC8_HUMANBioGRID30480076 details
SASH1_HUMAN1433S_HUMANBioGRID, MINT15778465 details
SASH1_HUMANSUV92_HUMANBioGRID20084102 details
SASH1_HUMANIRAK1_HUMANBioGRID23776175 details
SASH1_HUMANIRAK4_HUMANBioGRID23776175 details
SASH1_HUMANMYD88_HUMANBioGRID23776175 details
SASH1_HUMANM3K7_HUMANBioGRID23776175 details
SASH1_HUMANIKKA_HUMANBioGRID23776175 details
SASH1_HUMANNEMO_HUMANBioGRID23776175 details