Entity Details

Primary name LDHA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00338
EntryNameLDHA_HUMAN
FullNameL-lactate dehydrogenase A chain
TaxID9606
Evidenceevidence at protein level
Length332
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesLDHA

GO terms

Show/Hide Table
GOName
GO:0001666 response to hypoxia
GO:0004459 L-lactate dehydrogenase activity
GO:0005634 nucleus
GO:0005829 cytosol
GO:0006089 lactate metabolic process
GO:0006090 pyruvate metabolic process
GO:0006096 glycolytic process
GO:0007584 response to nutrient
GO:0009749 response to glucose
GO:0016020 membrane
GO:0019674 NAD metabolic process
GO:0019900 kinase binding
GO:0021762 substantia nigra development
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043627 response to estrogen
GO:0045296 cadherin binding
GO:0048569 post-embryonic animal organ development
GO:0051287 NAD binding
GO:0051591 response to cAMP
GO:0070062 extracellular exosome

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR001236 Lactate/malate dehydrogenase, N-terminalDomainDomain
IPR001557 L-lactate/malate dehydrogenaseFamilyFamily
IPR011304 L-lactate dehydrogenaseFamilyFamily
IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminalFamilyHomologous superfamily
IPR018177 L-lactate dehydrogenase, active siteSiteActive site
IPR022383 Lactate/malate dehydrogenase, C-terminalDomainDomain
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB02483 Etheno-NADDrugbanksmall molecule
DB02701 NicotinamideDrugbanksmall molecule
DB03940 Oxamic AcidDrugbanksmall molecule
DB09118 StiripentolDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB11638 ArtenimolDrugbanksmall molecule

Interactions

38 interactions

InteractorPartnerSourcesPublicationsLink
LDHA_HUMANXRN1_HUMANBioGRID, HPRD, IntAct15231747 details
LDHA_HUMANUB2E2_HUMANIntAct19549727 details
LDHA_HUMANLDHA_HUMANBioGRID, HPRD, IntAct11276087 21988832 25502805 31515488 details
LDHA_HUMANLDHB_HUMANBioGRID, IntAct21516116 21988832 22863883 22939629 25416956 25910212 28514442 31515488 32296183 details
LDHA_HUMANHSP7C_HUMANIntAct23523103 details
LDHA_HUMANAP2A_HUMANIntAct24835590 details
LDHA_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
LDHA_HUMANTINF2_HUMANbhf-ucl, BioGRID21044950 details
LDHA_HUMANACD_HUMANbhf-ucl, BioGRID21044950 details
LDHA_HUMANPOTE1_HUMANbhf-ucl, BioGRID21044950 details
LDHA_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
LDHA_HUMANPCNA_HUMANBioGRID, UniProt20849852 26030842 details
LDHA_HUMANMK10_HUMANBioGRID, IntAct25416956 31515488 32296183 details
LDHA_HUMANGSK3A_HUMANBioGRID, UniProt30824926 details
LDHA_HUMANPAXI1_HUMANBioGRID22990118 details
LDHA_HUMANRENT2_HUMANBioGRID15231747 details
LDHA_HUMAN1433T_HUMANBioGRID15161933 details
LDHA_HUMANPTPRF_HUMANBioGRID25458010 details
LDHA_HUMANFGFR1_HUMANBioGRID32572027 details
LDHA_HUMAN1433Z_HUMANMINT15161933 details
LDHA_HUMANHIF1A_HUMANBioGRID, IntAct21620138 25974097 details
LDHA_HUMANARNT_HUMANBioGRID, IntAct21620138 25974097 details
LDHA_HUMANKCJ11_HUMANBioGRID12145195 details
LDHA_HUMANABCC9_HUMANBioGRID, HPRD12145195 details
LDHA_HUMANKAT5_HUMANBioGRID20946988 details
LDHA_HUMANKAT2A_HUMANBioGRID20946988 details
LDHA_HUMANHDAC5_HUMANBioGRID21081666 details
LDHA_HUMANAKT1_HUMANBioGRID16027165 details
LDHA_HUMANHNF1A_HUMANBioGRID18160415 details
LDHA_HUMANHS90A_HUMANBioGRID16263121 details
LDHA_HUMANEFMT3_HUMANBioGRID23349634 details
LDHA_HUMANITA4_HUMANBioGRID22623428 details
LDHA_HUMANSQSTM_HUMANBioGRID26043024 32859246 details
LDHA_HUMANMTG16_HUMANBioGRID25974097 details
LDHA_HUMANCPT1A_HUMANBioGRID32859246 details
LDHA_HUMANATG5_HUMANBioGRID33024031 details
LDHA_HUMANHNRPD_HUMANHPRD12107167 details
LDHA_HUMANDYL1_HUMANHPRD14760703 details