Entity Details

Primary name CO5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01031
EntryNameCO5_HUMAN
FullNameComplement C5
TaxID9606
Evidenceevidence at protein level
Length1676
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesC5

GO terms

Show/Hide Table
GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001701 in utero embryonic development
GO:0004866 endopeptidase inhibitor activity
GO:0005102 signaling receptor binding
GO:0005576 extracellular region
GO:0005579 membrane attack complex
GO:0005615 extracellular space
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006956 complement activation
GO:0006957 complement activation, alternative pathway
GO:0006958 complement activation, classical pathway
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0008009 chemokine activity
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010760 negative regulation of macrophage chemotaxis
GO:0019835 cytolysis
GO:0030449 regulation of complement activation
GO:0032722 positive regulation of chemokine production
GO:0045766 positive regulation of angiogenesis
GO:0070062 extracellular exosome

Subcellular Location

Show/Hide Table
Subcellular Location
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR000020 Anaphylatoxin/fibulinDomainDomain
IPR001134 Netrin domainDomainDomain
IPR001599 Alpha-2-macroglobulinDomainDomain
IPR001840 Anaphylatoxin, complement system domainDomainDomain
IPR002890 Macroglobulin domainDomainDomain
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroidFamilyHomologous superfamily
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-foldFamilyHomologous superfamily
IPR009048 Alpha-macroglobulin, receptor-bindingDomainDomain
IPR011625 Alpha-2-macroglobulin, bait region domainDomainDomain
IPR011626 Alpha-macroglobulin-like, TED domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR018081 Anaphylatoxin, complement systemFamilyHomologous superfamily
IPR018933 Netrin module, non-TIMP typeDomainDomain
IPR036595 Alpha-macroglobulin, receptor-binding domain superfamilyFamilyHomologous superfamily
IPR037562 Complement C5FamilyFamily
IPR040839 Macroglobulin domain MG4DomainDomain
IPR041425 Complement C3/4/5, macroglobulin domain MG1DomainDomain
IPR041555 Macroglobulin domain MG3DomainDomain

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00028 Human immunoglobulin GDrugbankbiotech
DB01257 EculizumabDrugbankbiotech
DB01593 ZincDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB11580 RavulizumabDrugbankbiotech
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule