Entity Details

Primary name TGFB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01137
EntryNameTGFB1_HUMAN
FullNameTransforming growth factor beta-1 proprotein
TaxID9606
Evidenceevidence at protein level
Length390
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesTGFB1

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001570 vasculogenesis
GO:0001837 epithelial to mesenchymal transition
GO:0001843 neural tube closure
GO:0001933 negative regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0002062 chondrocyte differentiation
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002248 connective tissue replacement involved in inflammatory response wound healing
GO:0002576 platelet degranulation
GO:0003179 heart valve morphogenesis
GO:0003180 aortic valve morphogenesis
GO:0003823 antigen binding
GO:0005114 type II transforming growth factor beta receptor binding
GO:0005125 cytokine activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006611 protein export from nucleus
GO:0006754 ATP biosynthetic process
GO:0006796 phosphate-containing compound metabolic process
GO:0006954 inflammatory response
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007182 common-partner SMAD protein phosphorylation
GO:0007183 SMAD protein complex assembly
GO:0007435 salivary gland morphogenesis
GO:0007507 heart development
GO:0008083 growth factor activity
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0009611 response to wounding
GO:0009986 cell surface
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010716 negative regulation of extracellular matrix disassembly
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010742 macrophage derived foam cell differentiation
GO:0010763 positive regulation of fibroblast migration
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010936 negative regulation of macrophage cytokine production
GO:0014008 positive regulation of microglia differentiation
GO:0016202 regulation of striated muscle tissue development
GO:0016477 cell migration
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0019221 cytokine-mediated signaling pathway
GO:0019899 enzyme binding
GO:0021915 neural tube development
GO:0022408 negative regulation of cell-cell adhesion
GO:0030214 hyaluronan catabolic process
GO:0030308 negative regulation of cell growth
GO:0030334 regulation of cell migration
GO:0030335 positive regulation of cell migration
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031012 extracellular matrix
GO:0031093 platelet alpha granule lumen
GO:0031293 membrane protein intracellular domain proteolysis
GO:0031334 positive regulation of protein-containing complex assembly
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032355 response to estradiol
GO:0032570 response to progesterone
GO:0032740 positive regulation of interleukin-17 production
GO:0032801 receptor catabolic process
GO:0032930 positive regulation of superoxide anion generation
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034713 type I transforming growth factor beta receptor binding
GO:0034714 type III transforming growth factor beta receptor binding
GO:0035307 positive regulation of protein dephosphorylation
GO:0042127 regulation of cell population proliferation
GO:0042306 regulation of protein import into nucleus
GO:0042307 positive regulation of protein import into nucleus
GO:0042802 identical protein binding
GO:0043117 positive regulation of vascular permeability
GO:0043406 positive regulation of MAP kinase activity
GO:0043491 protein kinase B signaling
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043932 ossification involved in bone remodeling
GO:0045216 cell-cell junction organization
GO:0045596 negative regulation of cell differentiation
GO:0045599 negative regulation of fat cell differentiation
GO:0045662 negative regulation of myoblast differentiation
GO:0045786 negative regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045918 negative regulation of cytolysis
GO:0045930 negative regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048298 positive regulation of isotype switching to IgA isotypes
GO:0048535 lymph node development
GO:0048642 negative regulation of skeletal muscle tissue development
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050714 positive regulation of protein secretion
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050900 leukocyte migration
GO:0050921 positive regulation of chemotaxis
GO:0051098 regulation of binding
GO:0051101 regulation of DNA binding
GO:0051781 positive regulation of cell division
GO:0051897 positive regulation of protein kinase B signaling
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060312 regulation of blood vessel remodeling
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060390 regulation of SMAD protein signal transduction
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0060395 SMAD protein signal transduction
GO:0060965 negative regulation of gene silencing by miRNA
GO:0062023 collagen-containing extracellular matrix
GO:0070168 negative regulation of biomineral tissue development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070723 response to cholesterol
GO:0071407 cellular response to organic cyclic compound
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0072562 blood microparticle
GO:0085029 extracellular matrix assembly
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:1900126 negative regulation of hyaluronan biosynthetic process
GO:1900182 positive regulation of protein localization to nucleus
GO:1901203 positive regulation of extracellular matrix assembly
GO:1901666 positive regulation of NAD+ ADP-ribosyltransferase activity
GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903077 negative regulation of protein localization to plasma membrane
GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:1905313 transforming growth factor beta receptor signaling pathway involved in heart development
GO:1990402 embryonic liver development
GO:2000679 positive regulation of transcription regulatory region DNA binding
GO:2000727 positive regulation of cardiac muscle cell differentiation

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001111 TGF-beta, propeptideDomainDomain
IPR001839 Transforming growth factor-beta, C-terminalDomainDomain
IPR003939 Transforming growth factor beta-1 proproteinFamilyFamily
IPR015615 Transforming growth factor-beta-relatedFamilyFamily
IPR016319 Transforming growth factor-betaFamilyFamily
IPR017948 Transforming growth factor beta, conserved siteSiteConserved site
IPR029034 Cystine-knot cytokineFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00070 Hyaluronidase (ovine)Drugbankbiotech
DB01162 TerazosinDrugbanksmall molecule
DB06205 Hyaluronidase (human recombinant)Drugbankbiotech
DB10770 Foreskin fibroblast (neonatal)Drugbankbiotech
DB10772 Foreskin keratinocyte (neonatal)Drugbankbiotech
DB14740 HyaluronidaseDrugbankbiotech

Interactions

108 interactions

InteractorPartnerSourcesPublicationsLink
TGFB1_HUMANFSTL1_HUMANMINT20860622 details
TGFB1_HUMANTGFR2_HUMANBioGRID, HPRD, I2D, MINT11157754 20856203 20860622 21054789 21441952 7935686 8242742 8389764 details
TGFB1_HUMANDIP2A_HUMANMINT20860622 details
TGFB1_HUMANWFKN1_HUMANMINT21054789 details
TGFB1_HUMANWFKN2_HUMANMINT21054789 details
TGFB1_HUMANLAMB1_HUMANBioGRID, IntAct20936779 27684187 details
TGFB1_HUMANEGLN_HUMANBioGRID, HPRD, I2D12015308 1326540 20856203 details
TGFB1_HUMANTGBR3_HUMANBioGRID, HPRD, I2D20856203 7935686 8106553 details
TGFB1_HUMANTGFR1_HUMANBioGRID, HPRD, I2D10716993 15597342 20856203 8235612 details
TGFB1_HUMANTSP1_HUMANBioGRID, HPRD, UniProt1550960 15864306 details
TGFB1_HUMANMMP9_HUMANBioGRID, IntAct10652271 25241761 details
TGFB1_HUMANMMP2_HUMANBioGRID, HPRD, IntAct10652271 25241761 details
TGFB1_HUMANAPC_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANAURKA_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANAXIN2_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANBCL10_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANBMR1A_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANBUB1_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANARF_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANRHG07_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANEGFR_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANERBB2_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANFBXW7_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANCRCM_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANMLH3_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANPGFRL_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANTLR2_HUMANBioGRID, MINT24412244 details
TGFB1_HUMANAGR3_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANANGL4_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANBCAS3_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANBLID_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANCCL5_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANCYTM_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANDIRA3_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANGREB1_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANHXC6_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANKLK5_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANKLK7_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANKLK9_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANMTA3_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANPDLI2_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANHOP2_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANSG3A1_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANSNAI1_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANST14_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANTHRSP_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANTSP50_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANNSD3_HUMANBioGRID, MINT25640309 details
TGFB1_HUMANCO5A1_HUMANmatrixdb20979576 details
TGFB1_HUMANMEOX2_HUMANBioGRID, IntAct25416956 details
TGFB1_HUMANLTBP1_HUMANBioGRID, DIP, HPIDb10930463 12429738 21677751 details
TGFB1_HUMANLCE3B_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANLCE2C_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANPO4F2_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANKRA11_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANLCE1A_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANPDIA1_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANLPXN_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANKR108_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANHXA1_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANATL4_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANLCE1D_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANLCE2B_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANKR411_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANCTSR1_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANLCE3A_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANLCE1C_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANLCE3D_HUMANBioGRID, IntAct32296183 details
TGFB1_HUMANPSG1_HUMANIntAct25548275 details
TGFB1_HUMANPSG9_HUMANIntAct27389696 details
TGFB1_HUMANTGFB1_HUMANDIP, HPRD10930463 21677751 7935686 8617200 details
TGFB1_HUMANFNTA_HUMANBioGRID, HPRD8599089 details
TGFB1_HUMANVASN_HUMANBioGRID, HPRD15247411 details
TGFB1_HUMANCO2A1_HUMANBioGRID, HPRD10085302 details
TGFB1_HUMANPGS2_HUMANBioGRID, HPRD7638106 7798269 8093006 9675033 details
TGFB1_HUMANPGS1_HUMANBioGRID, HPRD10383378 8093006 details
TGFB1_HUMANFMOD_HUMANBioGRID, HPRD8093006 details
TGFB1_HUMANVTNC_HUMANBioGRID, HPRD11796824 details
TGFB1_HUMAN1433E_HUMANBioGRID, HPRD11172812 details
TGFB1_HUMANFKB1A_HUMANBioGRID11960000 23734213 details
TGFB1_HUMANCCD33_HUMANBioGRID25416956 details
TGFB1_HUMANLTOR5_HUMANBioGRID23241634 details
TGFB1_HUMANRPGF3_HUMANBioGRID32296183 details
TGFB1_HUMANFCHO1_HUMANBioGRID32296183 details
TGFB1_HUMANKRA13_HUMANBioGRID32296183 details
TGFB1_HUMANCDN2A_HUMANBioGRID24412244 details
TGFB1_HUMANA4_HUMANBioGRID, HPRD, IntAct12867422 2119582 25241761 27684187 details
TGFB1_HUMANCILP1_HUMANUniProt15864306 details
TGFB1_HUMANLRC32_HUMANBioGRID, DIP, IntAct19651619 28514442 details
TGFB1_HUMANITAV_HUMANDIP, HPRD11970960 21677751 details
TGFB1_HUMANFCN1_HUMANBioGRID, HPRD7686157 details
TGFB1_HUMANACVL1_HUMANBioGRID, HPRD10716993 8242742 details
TGFB1_HUMANEPS15_HUMANBioGRID19109251 details
TGFB1_HUMANTGFB2_HUMANBioGRID, HPRD11157754 27684187 details
TGFB1_HUMANP85A_HUMANBioGRID15657037 details
TGFB1_HUMANSPRC_HUMANHPRD15034927 details
TGFB1_HUMANCCL3_HUMANHPRD8568261 details
TGFB1_HUMANLTBP3_HUMANHPRD12062452 details
TGFB1_HUMANEIF3I_HUMANHPRD9813058 details
TGFB1_HUMANITB8_HUMANHPRD11970960 details
TGFB1_HUMANLTBP4_HUMANHPRD9660815 details
TGFB1_HUMANBMP2_HUMANHPRD11456401 details
TGFB1_HUMANBMP3_HUMANHPRD9434787 details
TGFB1_HUMANDERM_HUMANHPRD9895299 details
TGFB1_HUMANCCN2_HUMANHPRD10457363 details
TGFB1_HUMANSDC2_HUMANHPRD14976204 details
TGFB1_HUMANITB6_HUMANHPRD10025398 details