Entity Details

Primary name APOE_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP02649
EntryNameAPOE_HUMAN
FullNameApolipoprotein E
TaxID9606
Evidenceevidence at protein level
Length317
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesAPOE

GO terms

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GOName
GO:0000302 response to reactive oxygen species
GO:0001523 retinoid metabolic process
GO:0001540 amyloid-beta binding
GO:0001937 negative regulation of endothelial cell proliferation
GO:0002021 response to dietary excess
GO:0005102 signaling receptor binding
GO:0005198 structural molecule activity
GO:0005319 lipid transporter activity
GO:0005543 phospholipid binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006641 triglyceride metabolic process
GO:0006707 cholesterol catabolic process
GO:0006874 cellular calcium ion homeostasis
GO:0006898 receptor-mediated endocytosis
GO:0007010 cytoskeleton organization
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007263 nitric oxide mediated signal transduction
GO:0007271 synaptic transmission, cholinergic
GO:0007616 long-term memory
GO:0008201 heparin binding
GO:0008203 cholesterol metabolic process
GO:0008289 lipid binding
GO:0010467 gene expression
GO:0010544 negative regulation of platelet activation
GO:0010596 negative regulation of endothelial cell migration
GO:0010629 negative regulation of gene expression
GO:0010873 positive regulation of cholesterol esterification
GO:0010875 positive regulation of cholesterol efflux
GO:0010877 lipid transport involved in lipid storage
GO:0010976 positive regulation of neuron projection development
GO:0010977 negative regulation of neuron projection development
GO:0015909 long-chain fatty acid transport
GO:0016020 membrane
GO:0016209 antioxidant activity
GO:0017038 protein import
GO:0019068 virion assembly
GO:0019934 cGMP-mediated signaling
GO:0030195 negative regulation of blood coagulation
GO:0030425 dendrite
GO:0030516 regulation of axon extension
GO:0030522 intracellular receptor signaling pathway
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031012 extracellular matrix
GO:0031175 neuron projection development
GO:0032269 negative regulation of cellular protein metabolic process
GO:0032489 regulation of Cdc42 protein signal transduction
GO:0032805 positive regulation of low-density lipoprotein particle receptor catabolic process
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0034361 very-low-density lipoprotein particle
GO:0034362 low-density lipoprotein particle
GO:0034363 intermediate-density lipoprotein particle
GO:0034364 high-density lipoprotein particle
GO:0034365 discoidal high-density lipoprotein particle
GO:0034371 chylomicron remodeling
GO:0034372 very-low-density lipoprotein particle remodeling
GO:0034374 low-density lipoprotein particle remodeling
GO:0034375 high-density lipoprotein particle remodeling
GO:0034378 chylomicron assembly
GO:0034380 high-density lipoprotein particle assembly
GO:0034382 chylomicron remnant clearance
GO:0034384 high-density lipoprotein particle clearance
GO:0034447 very-low-density lipoprotein particle clearance
GO:0035641 locomotory exploration behavior
GO:0042158 lipoprotein biosynthetic process
GO:0042159 lipoprotein catabolic process
GO:0042311 vasodilation
GO:0042627 chylomicron
GO:0042632 cholesterol homeostasis
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042982 amyloid precursor protein metabolic process
GO:0043025 neuronal cell body
GO:0043083 synaptic cleft
GO:0043254 regulation of protein-containing complex assembly
GO:0043395 heparan sulfate proteoglycan binding
GO:0043407 negative regulation of MAP kinase activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0043687 post-translational protein modification
GO:0043691 reverse cholesterol transport
GO:0044267 cellular protein metabolic process
GO:0044794 positive regulation by host of viral process
GO:0044877 protein-containing complex binding
GO:0045088 regulation of innate immune response
GO:0045541 negative regulation of cholesterol biosynthetic process
GO:0045807 positive regulation of endocytosis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046889 positive regulation of lipid biosynthetic process
GO:0046907 intracellular transport
GO:0046911 metal chelating activity
GO:0046983 protein dimerization activity
GO:0048156 tau protein binding
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048844 artery morphogenesis
GO:0050709 negative regulation of protein secretion
GO:0050728 negative regulation of inflammatory response
GO:0050750 low-density lipoprotein particle receptor binding
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051055 negative regulation of lipid biosynthetic process
GO:0051246 regulation of protein metabolic process
GO:0051651 maintenance of location in cell
GO:0055089 fatty acid homeostasis
GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity
GO:0060999 positive regulation of dendritic spine development
GO:0061000 negative regulation of dendritic spine development
GO:0061136 regulation of proteasomal protein catabolic process
GO:0061771 response to caloric restriction
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0070326 very-low-density lipoprotein particle receptor binding
GO:0070328 triglyceride homeostasis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071682 endocytic vesicle lumen
GO:0071813 lipoprotein particle binding
GO:0071830 triglyceride-rich lipoprotein particle clearance
GO:0071831 intermediate-density lipoprotein particle clearance
GO:0072562 blood microparticle
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090181 regulation of cholesterol metabolic process
GO:0090209 negative regulation of triglyceride metabolic process
GO:0090370 negative regulation of cholesterol efflux
GO:0097113 AMPA glutamate receptor clustering
GO:0097114 NMDA glutamate receptor clustering
GO:0098978 glutamatergic synapse
GO:0120020 cholesterol transfer activity
GO:1900221 regulation of amyloid-beta clearance
GO:1900223 positive regulation of amyloid-beta clearance
GO:1900272 negative regulation of long-term synaptic potentiation
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1901627 negative regulation of postsynaptic membrane organization
GO:1901631 positive regulation of presynaptic membrane organization
GO:1902004 positive regulation of amyloid-beta formation
GO:1902430 negative regulation of amyloid-beta formation
GO:1902947 regulation of tau-protein kinase activity
GO:1902951 negative regulation of dendritic spine maintenance
GO:1902952 positive regulation of dendritic spine maintenance
GO:1902991 regulation of amyloid precursor protein catabolic process
GO:1902995 positive regulation of phospholipid efflux
GO:1902998 positive regulation of neurofibrillary tangle assembly
GO:1902999 negative regulation of phospholipid efflux
GO:1903001 negative regulation of lipid transport across blood-brain barrier
GO:1903002 positive regulation of lipid transport across blood-brain barrier
GO:1903561 extracellular vesicle
GO:1905855 positive regulation of heparan sulfate binding
GO:1905860 positive regulation of heparan sulfate proteoglycan binding
GO:1905890 regulation of cellular response to very-low-density lipoprotein particle stimulus
GO:1905906 regulation of amyloid fibril formation
GO:1905907 negative regulation of amyloid fibril formation
GO:1905908 positive regulation of amyloid fibril formation
GO:1990777 lipoprotein particle
GO:2000822 regulation of behavioral fear response

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000074 Apolipoprotein A/EFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

99 interactions

InteractorPartnerSourcesPublicationsLink
APOE_HUMANHPT_HUMANMINT19758344 details
APOE_HUMANPDCD4_HUMANBioGRID, IntAct21163940 details
APOE_HUMANCDC37_HUMANBioGRID, IntAct21163940 details
APOE_HUMANECSIT_HUMANBioGRID, IntAct21163940 details
APOE_HUMANF10A1_HUMANBioGRID, IntAct21163940 details
APOE_HUMANA2MG_HUMANBioGRID, HPRD, IntAct21163940 9831625 details
APOE_HUMANGCDH_HUMANBioGRID, IntAct21163940 details
APOE_HUMANCP2C8_HUMANBioGRID, IntAct21163940 details
APOE_HUMANLOXL4_HUMANBioGRID, IntAct21163940 details
APOE_HUMANIFIT3_HUMANBioGRID, IntAct21163940 details
APOE_HUMANMAST1_HUMANBioGRID, IntAct21163940 details
APOE_HUMANPSN1_HUMANBioGRID, IntAct21163940 details
APOE_HUMANRNF32_HUMANBioGRID, IntAct21163940 details
APOE_HUMANTMCC2_HUMANIntAct21593558 details
APOE_HUMANARFG1_HUMANBioGRID, IntAct21988832 details
APOE_HUMANLRP8_HUMANbhf-ucl, BioGRID, HPRD, IntAct12167620 12950167 32814053 8626535 details
APOE_HUMANLDLR_HUMANHPRD, MINT, UniProt12036962 20030366 24447298 details
APOE_HUMANSORL_HUMANbhf-ucl, BioGRID11294867 17326667 details
APOE_HUMANAPOE_HUMANbhf-ucl, BioGRID, HPRD, UniProt15182176 21163940 7566652 8245722 9147408 details
APOE_HUMANVLDLR_HUMANDIP, HPRD12167620 19116273 details
APOE_HUMANTAU_HUMANBioGRID, HPRD, IntAct, UniProt26402096 32814053 7566652 8620924 9147408 9512010 details
APOE_HUMANLRP1_HUMANBioGRID, HPRD, UniProt11421580 15182176 20030366 2779654 details
APOE_HUMANTREM2_HUMANBioGRID, UniProt27477018 30341064 details
APOE_HUMANCFAH_HUMANIntAct26468283 details
APOE_HUMANSYUA_HUMANBioGRID, IntAct26921451 28887769 31270237 details
APOE_HUMANLEG1_HUMANIntAct32814053 details
APOE_HUMANCNTF_HUMANHPRD, IntAct32814053 9236223 details
APOE_HUMANSCRB1_HUMANHPRD, IntAct12138091 32814053 details
APOE_HUMANAPLP2_HUMANIntAct32814053 details
APOE_HUMANZNF24_HUMANIntAct32814053 details
APOE_HUMANBACD2_HUMANIntAct32814053 details
APOE_HUMANMT2_HUMANIntAct32814053 details
APOE_HUMANMTAP2_HUMANIntAct32814053 details
APOE_HUMANFX4L6_HUMANIntAct32814053 details
APOE_HUMANCT141_HUMANIntAct32814053 details
APOE_HUMANSPA2L_HUMANIntAct32814053 details
APOE_HUMANLDH6B_HUMANIntAct32814053 details
APOE_HUMANCK049_HUMANIntAct32814053 details
APOE_HUMANDCR1B_HUMANIntAct32814053 details
APOE_HUMANUTP6_HUMANIntAct32814053 details
APOE_HUMANRN111_HUMANIntAct32814053 details
APOE_HUMANKAD3_HUMANIntAct32814053 details
APOE_HUMANVPP4_HUMANIntAct32814053 details
APOE_HUMANHYPM_HUMANIntAct32814053 details
APOE_HUMANTTC33_HUMANIntAct32814053 details
APOE_HUMANMSRB2_HUMANIntAct32814053 details
APOE_HUMANRASF1_HUMANIntAct32814053 details
APOE_HUMANEMIL1_HUMANIntAct32814053 details
APOE_HUMANRBM5_HUMANIntAct32814053 details
APOE_HUMANUBA3_HUMANIntAct32814053 details
APOE_HUMANLRP2_HUMANBioGRID, HPRD11421580 7768901 details
APOE_HUMANNFM_HUMANBioGRID, HPRD8620924 details
APOE_HUMANCSK21_HUMANBioGRID15882073 details
APOE_HUMANTIM29_HUMANBioGRID21163940 details
APOE_HUMANCP2CI_HUMANBioGRID21163940 details
APOE_HUMANELAV1_HUMANBioGRID21163940 details
APOE_HUMANSYFA_HUMANBioGRID21163940 details
APOE_HUMANFXL12_HUMANBioGRID21163940 details
APOE_HUMANIFIT5_HUMANBioGRID21163940 details
APOE_HUMANLONM_HUMANBioGRID21163940 31536960 details
APOE_HUMANNOS3_HUMANBioGRID21163940 details
APOE_HUMANPRAM_HUMANBioGRID21163940 details
APOE_HUMANPRDX2_HUMANBioGRID21163940 details
APOE_HUMANRHEB_HUMANBioGRID21163940 details
APOE_HUMANACTG_HUMANBioGRID21163940 27684187 details
APOE_HUMANANKH_HUMANBioGRID21163940 details
APOE_HUMANEPN2_HUMANBioGRID21163940 details
APOE_HUMANFOXG1_HUMANBioGRID21163940 details
APOE_HUMANFXYD7_HUMANBioGRID21163940 details
APOE_HUMANHTRA1_HUMANBioGRID21163940 details
APOE_HUMANIQEC1_HUMANBioGRID21163940 details
APOE_HUMANM1IP1_HUMANBioGRID21163940 details
APOE_HUMANPIMT_HUMANBioGRID21163940 details
APOE_HUMANPKHA6_HUMANBioGRID21163940 details
APOE_HUMANRL4_HUMANBioGRID21163940 27684187 details
APOE_HUMANTYRO3_HUMANBioGRID21163940 details
APOE_HUMANZN558_HUMANBioGRID21163940 details
APOE_HUMANLCAT_HUMANBioGRID15654758 details
APOE_HUMANHS90A_HUMANBioGRID31273033 details
APOE_HUMANALBU_HUMANBioGRID, HPRD, IntAct15174051 8063017 details
APOE_HUMANAPOA2_HUMANbhf-ucl8245722 details
APOE_HUMANAPOC2_HUMANbhf-ucl8245722 details
APOE_HUMANA4_HUMANBioGRID, HPRD, MINT10559559 22528093 26213366 details
APOE_HUMANCSTN3_HUMANMINT26213366 details
APOE_HUMANTREM1_HUMANUniProt30341064 details
APOE_HUMANTOPRS_HUMANIntAct31413325 details
APOE_HUMANPIAS3_HUMANIntAct31413325 details
APOE_HUMANHIPK1_HUMANIntAct31413325 details
APOE_HUMANZN451_HUMANIntAct31413325 details
APOE_HUMANPLAG1_HUMANIntAct31413325 details
APOE_HUMANRU17_HUMANIntAct31413325 details
APOE_HUMANUBC9_HUMANIntAct31413325 details
APOE_HUMANPIAS1_HUMANIntAct31413325 details
APOE_HUMANPIAS2_HUMANIntAct31413325 details
APOE_HUMANCLCF1_HUMANIntAct29507344 details
APOE_HUMANPLTP_HUMANBioGRID, HPRD12810820 details
APOE_HUMANITAM_HUMANBioGRID23134465 details
APOE_HUMANCATB_HUMANHPRD12057992 details
APOE_HUMANPRIO_HUMANHPRD15146195 details