Entity Details

Primary name AMYP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP04746
EntryNameAMYP_HUMAN
FullNamePancreatic alpha-amylase
TaxID9606
Evidenceevidence at protein level
Length511
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesAMY2A

GO terms

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GOName
GO:0004556 alpha-amylase activity
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005975 carbohydrate metabolic process
GO:0016052 carbohydrate catabolic process
GO:0031404 chloride ion binding
GO:0044245 polysaccharide digestion
GO:0070062 extracellular exosome
GO:0103025 alpha-amylase activity (releasing maltohexaose)

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR006046 Alpha amylaseFamilyFamily
IPR006047 Glycosyl hydrolase, family 13, catalytic domainDomainDomain
IPR006048 Alpha-amylase/branching enzyme, C-terminal all betaDomainDomain
IPR013780 Glycosyl hydrolase, all-betaFamilyHomologous superfamily
IPR017853 Glycoside hydrolase superfamilyFamilyHomologous superfamily
IPR031319 Alpha-amylase, C-terminal domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00284 AcarboseDrugbanksmall molecule
DB00491 MiglitolDrugbanksmall molecule
DB00702 IcodextrinSwissprotsmall molecule
DB01922 Maltosyl-Alpha (1,4)-D-Gluconhydroximo-1,5-LactamDrugbanksmall molecule
DB02218 N-[4-hydroxymethyl-cyclohexan-6-yl-1,2,3-triol]-4,6-dideoxy-4-aminoglucopyranosideDrugbanksmall molecule
DB02379 Beta-D-GlucoseDrugbanksmall molecule
DB02889 4-O-(4,6-Dideoxy-4-{[4,5,6-Trihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}-Beta-D-Lyxo-Hexopyranosyl)-Alpha-D-Erythro-HexopyranoseDrugbanksmall molecule
DB03088 Pidolic acidDrugbanksmall molecule
DB03092 5-Hydroxymethyl-ChonduritolDrugbanksmall molecule
DB03439 4,6-dideoxy-4-amino-alpha-D-glucoseDrugbanksmall molecule
DB03495 4,6-Dideoxy-4-{[4,5,6-Trihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}-Alpha-D-Lyxo-Hexopyranosyl-(1->4)-Alpha-D-Threo-Hexopyranosyl-(1->6)-Alpha-L-Threo-HexopyranoseDrugbanksmall molecule
DB03773 alpha-D-quinovopyranoseDrugbanksmall molecule
DB03971 Acarbose Derived HexasaccharideDrugbanksmall molecule
DB04453 4-O-(4,6-Dideoxy-4-{[4-[(4-O-Hexopyranosylhexopyranosyl)Oxy]-5,6-Dihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}Hexopyranosyl)HexopyranoseDrugbanksmall molecule
DB04618 4,6-DIDEOXY-4-{[4-[(4-O-HEXOPYRANOSYLHEXOPYRANOSYL)OXY]-5,6-DIHYDROXY-3-(HYDROXYMETHYL)CYCLOHEX-2-EN-1-YL]AMINO}HEXOPYRANOSYL-(1->4)HEXOPYRANOSYL-(1->4)HEXOPYRANOSEDrugbanksmall molecule

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
AMYP_HUMANTRIA1_HUMANBioGRID, IntAct21988832 details
AMYP_HUMANIGF1R_HUMANBioGRID, IntAct21988832 details
AMYP_HUMANGP2_HUMANHPRD1284286 details