Entity Details

Primary name S10A8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05109
EntryNameS10A8_HUMAN
FullNameProtein S100-A8
TaxID9606
Evidenceevidence at protein level
Length93
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesS100A8

GO terms

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GOName
GO:0002224 toll-like receptor signaling pathway
GO:0002523 leukocyte migration involved in inflammatory response
GO:0002526 acute inflammatory response
GO:0002544 chronic inflammatory response
GO:0002793 positive regulation of peptide secretion
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0006914 autophagy
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954 inflammatory response
GO:0008017 microtubule binding
GO:0008270 zinc ion binding
GO:0010043 response to zinc ion
GO:0014002 astrocyte development
GO:0018119 peptidyl-cysteine S-nitrosylation
GO:0019730 antimicrobial humoral response
GO:0030307 positive regulation of cell growth
GO:0030593 neutrophil chemotaxis
GO:0032119 sequestering of zinc ion
GO:0032496 response to lipopolysaccharide
GO:0034774 secretory granule lumen
GO:0035425 autocrine signaling
GO:0035662 Toll-like receptor 4 binding
GO:0042060 wound healing
GO:0042742 defense response to bacterium
GO:0043312 neutrophil degranulation
GO:0045087 innate immune response
GO:0045111 intermediate filament cytoskeleton
GO:0045471 response to ethanol
GO:0048306 calcium-dependent protein binding
GO:0050544 arachidonic acid binding
GO:0050729 positive regulation of inflammatory response
GO:0050786 RAGE receptor binding
GO:0050832 defense response to fungus
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051493 regulation of cytoskeleton organization
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0070488 neutrophil aggregation
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Secreted

Domains

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DomainNameCategoryType
IPR001751 S100/Calbindin-D9k, conserved siteSiteConserved site
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR013787 S100/CaBP-9k-type, calcium binding, subdomainDomainDomain
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR028474 Protein S100-A8FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB01373 CalciumDrugbanksmall molecule
DB01593 ZincDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

36 interactions

InteractorPartnerSourcesPublicationsLink
S10A8_HUMANU119A_HUMANBioGRID, HPRD, IntAct16169070 details
S10A8_HUMANSCG1_HUMANBioGRID, HPRD, IntAct16169070 details
S10A8_HUMANGDF9_HUMANBioGRID, HPRD, IntAct16169070 details
S10A8_HUMANIGS21_HUMANBioGRID, HPRD, IntAct16169070 details
S10A8_HUMANP53_HUMANBioGRID, HPRD, IntAct16169070 32807901 details
S10A8_HUMANTBA4A_HUMANHPRD, IntAct16169070 details
S10A8_HUMANERG28_HUMANBioGRID, HPRD, IntAct16169070 details
S10A8_HUMANANM1_HUMANBioGRID, HPRD, IntAct16169070 details
S10A8_HUMANRRP5_HUMANBioGRID, HPRD, IntAct16169070 details
S10A8_HUMANPPIA_HUMANBioGRID, HPRD, IntAct16169070 details
S10A8_HUMANKLC2_HUMANHPRD, IntAct16169070 details
S10A8_HUMANRAB17_HUMANHPRD, IntAct16169070 details
S10A8_HUMANS10A9_HUMANBioGRID, HPRD, IntAct12553726 15331440 20936779 24981860 25417112 9867828 details
S10A8_HUMANCDN1A_HUMANBioGRID, MINT21900206 details
S10A8_HUMANZNF16_HUMANUniProt21874239 details
S10A8_HUMANG3P_HUMANIntAct25417112 details
S10A8_HUMANNAC1_HUMANUniProt31837246 details
S10A8_HUMANTRPM4_HUMANUniProt31837246 details
S10A8_HUMANLRIF1_HUMANBioGRID, HPRD16169070 details
S10A8_HUMANA4_HUMANBioGRID21832049 details
S10A8_HUMANNCF2_HUMANBioGRID, HPRD15642721 details
S10A8_HUMANPTEN_HUMANBioGRID26561776 details
S10A8_HUMANTBB5_HUMANBioGRID15331440 details
S10A8_HUMANTBA1A_HUMANBioGRID15331440 details
S10A8_HUMANIKBB_HUMANIntAct14743216 details
S10A8_HUMANM3K3_HUMANIntAct14743216 details
S10A8_HUMANRIF1_HUMANIntAct16169070 details
S10A8_HUMANCDK2_HUMANBioGRID, IntAct17353931 21319273 details
S10A8_HUMANS10A8_HUMANBioGRID, HPRD10771424 23483999 details
S10A8_HUMANTERF1_HUMANBioGRID20811636 details
S10A8_HUMANTERF2_HUMANBioGRID20811636 details
S10A8_HUMANPOTE1_HUMANBioGRID20811636 details
S10A8_HUMANBECN1_HUMANBioGRID21971985 details
S10A8_HUMANSIR6_HUMANBioGRID24169447 details
S10A8_HUMANRNF5_HUMANBioGRID30232010 32614325 details
S10A8_HUMANCEAM3_HUMANHPRD11708798 details