Entity Details

Primary name FES_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07332
EntryNameFES_HUMAN
FullNameTyrosine-protein kinase Fes/Fps
TaxID9606
Evidenceevidence at protein level
Length822
SequenceStatuscomplete
DateCreated1988-04-01
DateModified2021-06-02

Ontological Relatives

GenesFES

GO terms

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GOName
GO:0001578 microtubule bundle formation
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0006935 chemotaxis
GO:0007098 centrosome cycle
GO:0007155 cell adhesion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008017 microtubule binding
GO:0008360 regulation of cell shape
GO:0010976 positive regulation of neuron projection development
GO:0015630 microtubule cytoskeleton
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030154 cell differentiation
GO:0030155 regulation of cell adhesion
GO:0031116 positive regulation of microtubule polymerization
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0034987 immunoglobulin receptor binding
GO:0035091 phosphatidylinositol binding
GO:0042127 regulation of cell population proliferation
GO:0043304 regulation of mast cell degranulation
GO:0045087 innate immune response
GO:0045595 regulation of cell differentiation
GO:0045639 positive regulation of myeloid cell differentiation
GO:0045657 positive regulation of monocyte differentiation
GO:0046777 protein autophosphorylation
GO:0060627 regulation of vesicle-mediated transport
GO:0071305 cellular response to vitamin D
GO:2000145 regulation of cell motility
GO:2000251 positive regulation of actin cytoskeleton reorganization

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Cytoplasmic vesicle
Golgi apparatus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001060 FCH domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016250 Tyrosine-protein kinase, Fes/Fps typeFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR027267 AH/BAR domain superfamilyFamilyHomologous superfamily
IPR031160 F-BAR domainDomainDomain
IPR035849 Fes/Fps/Fer, SH2 domainDomainDomain
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

46 interactions

InteractorPartnerSourcesPublicationsLink
FES_HUMANEGFR_HUMANBioGRID, MINT16273093 22973453 details
FES_HUMANEZRI_HUMANMINT18046454 details
FES_HUMANMDFI_HUMANBioGRID, IntAct19060904 details
FES_HUMANABI1_HUMANMINT20598684 details
FES_HUMANFES_HUMANBioGRID, HPRD, MINT26702831 7687763 8663427 details
FES_HUMANNSF_HUMANMINT15322554 details
FES_HUMANMYOME_HUMANBioGRID, MINT21900206 details
FES_HUMANZN746_HUMANBioGRID, MINT21900206 details
FES_HUMANZN775_HUMANBioGRID, MINT21900206 details
FES_HUMANANDR_HUMANBioGRID, IntAct24728074 details
FES_HUMANGAB1_HUMANBioGRID, IntAct24728074 details
FES_HUMANKIT_HUMANBioGRID, IntAct24728074 details
FES_HUMANMET_HUMANBioGRID, IntAct24728074 details
FES_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
FES_HUMANPOTE1_HUMANbhf-ucl, BioGRID21044950 details
FES_HUMANHSH2D_HUMANBioGRID, HPRD11700021 details
FES_HUMANBCR_HUMANBioGRID, HPRD10706130 7529874 8955135 details
FES_HUMANHS90A_HUMANBioGRID22939624 9222609 details
FES_HUMANHSP74_HUMANBioGRID9222609 details
FES_HUMANFKBP4_HUMANBioGRID9222609 details
FES_HUMANFKBP5_HUMANBioGRID9222609 details
FES_HUMANTEBP_HUMANBioGRID9222609 details
FES_HUMANPPID_HUMANBioGRID9222609 details
FES_HUMANNEDD4_HUMANBioGRID19953087 details
FES_HUMANTIF1B_HUMANBioGRID16792528 details
FES_HUMANA4_HUMANBioGRID21244100 details
FES_HUMANSMUF1_HUMANBioGRID20804422 details
FES_HUMANERBB2_HUMANBioGRID22973453 details
FES_HUMANERBB3_HUMANBioGRID22973453 details
FES_HUMANERBB4_HUMANBioGRID22973453 details
FES_HUMANHS90B_HUMANIntAct22939624 details
FES_HUMANSTAT3_HUMANBioGRID, HPRD9714332 details
FES_HUMANP85A_HUMANBioGRID, HPRD8916957 details
FES_HUMANBCAR1_HUMANHPRD8999909 details
FES_HUMANRASA3_HUMANHPRD7691175 details
FES_HUMANDPYL5_HUMANHPRD12093729 details
FES_HUMANPLXA1_HUMANHPRD12093729 details
FES_HUMANJAK2_HUMANHPRD8631962 details
FES_HUMANIL3RB_HUMANHPRD8631962 details
FES_HUMANIRS1_HUMANHPRD10856136 details
FES_HUMANJAK1_HUMANHPRD11160325 details
FES_HUMANJAK3_HUMANHPRD11160325 details
FES_HUMANIRS2_HUMANHPRD10856136 details
FES_HUMANDOK1_HUMANHPRD11071635 details
FES_HUMANRASA1_HUMANHPRD7691175 details
FES_HUMANIL4RA_HUMANHPRD7518439 details