Entity Details

Primary name YES_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07947
EntryNameYES_HUMAN
FullNameTyrosine-protein kinase Yes
TaxID9606
Evidenceevidence at protein level
Length543
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesYES1

GO terms

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GOName
GO:0001784 phosphotyrosine residue binding
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005794 Golgi apparatus
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006464 cellular protein modification process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0019899 enzyme binding
GO:0030154 cell differentiation
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031295 T cell costimulation
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043114 regulation of vascular permeability
GO:0044325 transmembrane transporter binding
GO:0045087 innate immune response
GO:0048013 ephrin receptor signaling pathway
GO:0050900 leukocyte migration
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035751 Tyrosine-protein kinase Yes, SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01254 DasatinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

122 interactions

InteractorPartnerSourcesPublicationsLink
YES_HUMANGPVI_HUMANDIP, HPRD, IntAct1715582 19940238 details
YES_HUMANZ512B_HUMANBioGRID, MINT15231748 details
YES_HUMANEGFR_HUMANBioGRID, IntAct, Molecular Connections15657067 22973453 23866081 24797263 details
YES_HUMANNHRF1_HUMANBioGRID, MINT10562288 details
YES_HUMANPAK2_HUMANHPRD, MINT16374509 details
YES_HUMANADA15_HUMANBioGRID, HPRD, MINT16374509 details
YES_HUMANCDN1B_HUMANHPRD, IntAct17254967 details
YES_HUMANMED28_HUMANBioGRID, MINT16964398 details
YES_HUMANRL10_HUMANBioGRID, HPRD, MINT12138090 16741966 details
YES_HUMANSPR2A_HUMANBioGRID, MINT18155796 details
YES_HUMANTNFL6_HUMANBioGRID, IntAct19807924 details
YES_HUMANABI1_HUMANMINT20598684 details
YES_HUMANDVL2_HUMANBioGRID, MINT21516116 details
YES_HUMANFAK1_HUMANBioGRID, IntAct12558988 23397142 25416956 32296183 details
YES_HUMANLOX5_HUMANMINT24860872 details
YES_HUMANANDR_HUMANBioGRID, IntAct24728074 32814769 details
YES_HUMANGAB1_HUMANBioGRID, IntAct24728074 details
YES_HUMANKIT_HUMANBioGRID, HPRD, IntAct11071635 24728074 details
YES_HUMANMET_HUMANBioGRID, IntAct24728074 details
YES_HUMANOLIG1_HUMANBioGRID, IntAct25814554 details
YES_HUMANBECN1_HUMANBioGRID, IntAct25814554 details
YES_HUMANSOCS3_HUMANBioGRID, IntAct25416956 32296183 details
YES_HUMANFXR2_HUMANBioGRID, IntAct25416956 32296183 details
YES_HUMANTRAF2_HUMANBioGRID, IntAct25416956 32296183 details
YES_HUMANCA094_HUMANBioGRID, IntAct25416956 details
YES_HUMANFUND1_HUMANBioGRID, IntAct25416956 31515488 details
YES_HUMANZBT8A_HUMANBioGRID, IntAct25416956 32296183 details
YES_HUMANSSBP3_HUMANBioGRID, IntAct25416956 32296183 details
YES_HUMANNIF3L_HUMANBioGRID, IntAct25416956 details
YES_HUMANTHAP1_HUMANBioGRID, IntAct25416956 32296183 details
YES_HUMANTRAF6_HUMANBioGRID, IntAct25416956 32296183 details
YES_HUMANPICK1_HUMANBioGRID, IntAct32296183 details
YES_HUMANPAXI_HUMANBioGRID, IntAct32296183 details
YES_HUMANEFS_HUMANBioGRID, IntAct32296183 details
YES_HUMANCRTP1_HUMANIntAct32296183 details
YES_HUMANSF3A2_HUMANIntAct32296183 details
YES_HUMANCPSF6_HUMANBioGRID, IntAct32296183 details
YES_HUMANCHM1A_HUMANBioGRID, IntAct32296183 details
YES_HUMANSOCS7_HUMANBioGRID, IntAct32296183 details
YES_HUMANCEP83_HUMANBioGRID, IntAct32296183 details
YES_HUMANJKIP1_HUMANBioGRID, IntAct32296183 details
YES_HUMANZC21A_HUMANBioGRID, IntAct32296183 details
YES_HUMANTRIM5_HUMANBioGRID, IntAct32296183 details
YES_HUMANDTX3_HUMANBioGRID, IntAct32296183 details
YES_HUMANLIN7C_HUMANBioGRID, IntAct32296183 details
YES_HUMANSOCS2_HUMANBioGRID, IntAct32296183 details
YES_HUMANSTAP2_HUMANBioGRID, IntAct32296183 details
YES_HUMANP55G_HUMANBioGRID, IntAct32296183 details
YES_HUMANCBLC_HUMANBioGRID, IntAct32296183 details
YES_HUMANFXR1_HUMANBioGRID, IntAct32296183 details
YES_HUMANBCAR1_HUMANBioGRID, IntAct32296183 details
YES_HUMANAMOL2_HUMANBioGRID, IntAct32296183 details
YES_HUMANBICD2_HUMANBioGRID, IntAct32296183 details
YES_HUMANIKZF3_HUMANBioGRID, IntAct32296183 details
YES_HUMANCBLB_HUMANBioGRID, IntAct32296183 details
YES_HUMANSHLB2_HUMANBioGRID, IntAct32296183 details
YES_HUMANCARD9_HUMANBioGRID, IntAct32296183 details
YES_HUMANDESM_HUMANBioGRID, IntAct32296183 details
YES_HUMANGFAP_HUMANBioGRID, IntAct32296183 details
YES_HUMANLASP1_HUMANBioGRID, IntAct32296183 details
YES_HUMANT10IP_HUMANBioGRID, IntAct32296183 details
YES_HUMANDRC4_HUMANBioGRID, IntAct32296183 details
YES_HUMANFACC1_HUMANBioGRID, IntAct32296183 details
YES_HUMANDDT4L_HUMANBioGRID, IntAct32296183 details
YES_HUMANDEN2C_HUMANBioGRID, IntAct32296183 details
YES_HUMANCE57L_HUMANBioGRID, IntAct32296183 details
YES_HUMANZN438_HUMANBioGRID, IntAct32296183 details
YES_HUMANDOK2_HUMANBioGRID, IntAct32296183 details
YES_HUMANCRKL_HUMANBioGRID, IntAct32296183 details
YES_HUMANFLT3_HUMANMINT28086240 details
YES_HUMANKHDR1_HUMANBioGRID, IntAct15190072 22745667 31413325 details
YES_HUMANCADH1_HUMANBioGRID12640114 details
YES_HUMANDOK1_HUMANBioGRID, HPRD11071635 details
YES_HUMANEPHB2_HUMANBioGRID9632142 details
YES_HUMANOGT1_HUMANBioGRID16434389 details
YES_HUMANNEDD4_HUMANBioGRID19953087 details
YES_HUMANCBL_HUMANBioGRID10829062 details
YES_HUMANACK1_HUMANBioGRID21309750 details
YES_HUMANPTEN_HUMANBioGRID26561776 details
YES_HUMANFGFR1_HUMANBioGRID16631103 details
YES_HUMANSKAP2_HUMANBioGRID29568343 details
YES_HUMANCCD33_HUMANBioGRID32296183 details
YES_HUMANERBB2_HUMANBioGRID22973453 details
YES_HUMANERBB3_HUMANBioGRID22973453 details
YES_HUMANERBB4_HUMANBioGRID22973453 details
YES_HUMANSOCS1_HUMANBioGRID31101761 details
YES_HUMANPDC6I_HUMANBioGRID, HPRD, MINT15557335 details
YES_HUMANTNR6_HUMANBioGRID, DIP, IntAct18328427 21713032 details
YES_HUMANPGFRB_HUMANHPRD, MINT7685273 details
YES_HUMANCDCP1_HUMANDIP, I2D21233420 21725358 details
YES_HUMANHS90B_HUMANBioGRID, IntAct22939624 31980649 details
YES_HUMANYAP1_HUMANBioGRID, IntAct23245941 31501420 details
YES_HUMANCDC37_HUMANBioGRID, IntAct25036637 28514442 31980649 details
YES_HUMANFYN_HUMANBioGRID, IntAct12640114 28514442 details
YES_HUMANVGFR1_HUMANHPRD, UniProt12509223 details
YES_HUMANADA10_HUMANUniProt25036101 details
YES_HUMANNPHN_HUMANBioGRID, HPRD12668668 12846735 details
YES_HUMANCTND1_HUMANBioGRID12640114 details
YES_HUMANOCLN_HUMANBioGRID, HPRD11950934 34079125 details
YES_HUMANRASA1_HUMANBioGRID, HPRD1544885 details
YES_HUMANCD36_HUMANBioGRID, HPRD1715582 7521304 details
YES_HUMANPECA1_HUMANBioGRID, HPRD10858437 details
YES_HUMANCSF1R_HUMANBioGRID, HPRD7681396 details
YES_HUMANTRPV4_HUMANBioGRID, HPRD12538589 details
YES_HUMANMCP_HUMANBioGRID, HPRD11901164 details
YES_HUMANFLOT1_HUMANBioGRID22936677 details
YES_HUMANACSL3_HUMANBioGRID20605918 details
YES_HUMANSRC8_HUMANBioGRID16631103 details
YES_HUMANSHC1_HUMANBioGRID7499252 details
YES_HUMANP85A_HUMANBioGRID7499252 details
YES_HUMANIL1R1_HUMANBioGRID7499252 details
YES_HUMANYES_HUMANBioGRID, HPRD31980649 9794236 details
YES_HUMANRON_HUMANHPRD8918464 details
YES_HUMANTYRO3_HUMANHPRD7537495 details
YES_HUMANADA12_HUMANHPRD11127814 details
YES_HUMANDLG4_HUMANHPRD9892651 details
YES_HUMANCD2AP_HUMANHPRD10339567 details
YES_HUMANASPP2_HUMANHPRD11278422 details
YES_HUMANPTPRE_HUMANHPRD14980517 15588985 details
YES_HUMANVGFR2_HUMANHPRD7929439 details
YES_HUMANITB4_HUMANHPRD11684709 details
YES_HUMANJAK2_HUMANHPRD8702385 details