Entity Details

Primary name ADA2A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08913
EntryNameADA2A_HUMAN
FullNameAlpha-2A adrenergic receptor
TaxID9606
Evidenceevidence at protein level
Length465
SequenceStatuscomplete
DateCreated1988-11-01
DateModified2021-06-02

Ontological Relatives

GenesADRA2A

GO terms

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GOName
GO:0001819 positive regulation of cytokine production
GO:0004930 G protein-coupled receptor activity
GO:0004938 alpha2-adrenergic receptor activity
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006940 regulation of smooth muscle contraction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007266 Rho protein signal transduction
GO:0008284 positive regulation of cell population proliferation
GO:0010700 negative regulation of norepinephrine secretion
GO:0016323 basolateral plasma membrane
GO:0019229 regulation of vasoconstriction
GO:0019901 protein kinase binding
GO:0030036 actin cytoskeleton organization
GO:0030168 platelet activation
GO:0030335 positive regulation of cell migration
GO:0031692 alpha-1B adrenergic receptor binding
GO:0031696 alpha-2C adrenergic receptor binding
GO:0031996 thioesterase binding
GO:0032147 activation of protein kinase activity
GO:0032148 activation of protein kinase B activity
GO:0032795 heterotrimeric G-protein binding
GO:0032811 negative regulation of epinephrine secretion
GO:0032870 cellular response to hormone stimulus
GO:0035624 receptor transactivation
GO:0042593 glucose homeostasis
GO:0042596 fear response
GO:0042803 protein homodimerization activity
GO:0043235 receptor complex
GO:0043268 positive regulation of potassium ion transport
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
GO:0045955 negative regulation of calcium ion-dependent exocytosis
GO:0046676 negative regulation of insulin secretion
GO:0046982 protein heterodimerization activity
GO:0050796 regulation of insulin secretion
GO:0050892 intestinal absorption
GO:0050995 negative regulation of lipid catabolic process
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051379 epinephrine binding
GO:0051380 norepinephrine binding
GO:0051926 negative regulation of calcium ion transport
GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0071875 adrenergic receptor signaling pathway
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway
GO:0071882 phospholipase C-activating adrenergic receptor signaling pathway
GO:0090303 positive regulation of wound healing
GO:0098691 dopaminergic synapse
GO:1901020 negative regulation of calcium ion transmembrane transporter activity
GO:2000300 regulation of synaptic vesicle exocytosis

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR001946 Alpha 2A adrenoceptorFamilyFamily
IPR002233 Adrenoceptor familyFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00182 AmphetamineDrugbanksmall molecule
DB00193 TramadolDrugbanksmall molecule
DB00217 BethanidineDrugbanksmall molecule
DB00246 ZiprasidoneDrugbanksmall molecule
DB00248 CabergolineDrugbanksmall molecule
DB00268 RopiniroleDrugbanksmall molecule
DB00320 DihydroergotamineDrugbanksmall molecule
DB00321 AmitriptylineDrugbanksmall molecule
DB00363 ClozapineDrugbanksmall molecule
DB00368 NorepinephrineDrugbanksmall molecule
DB00370 MirtazapineDrugbanksmall molecule
DB00397 PhenylpropanolamineDrugbanksmall molecule
DB00408 LoxapineDrugbanksmall molecule
DB00413 PramipexoleDrugbanksmall molecule
DB00433 ProchlorperazineDrugbanksmall molecule
DB00449 DipivefrinDrugbanksmall molecule
DB00457 PrazosinDrugbanksmall molecule
DB00477 ChlorpromazineDrugbanksmall molecule
DB00484 BrimonidineDrugbanksmall molecule
DB00502 HaloperidolDrugbanksmall molecule
DB00540 NortriptylineDrugbanksmall molecule
DB00543 AmoxapineDrugbanksmall molecule
DB00555 LamotrigineDrugbanksmall molecule
DB00575 ClonidineDrugbanksmall molecule
DB00589 LisurideDrugbanksmall molecule
DB00629 GuanabenzDrugbanksmall molecule
DB00633 DexmedetomidineDrugbanksmall molecule
DB00656 TrazodoneDrugbanksmall molecule
DB00668 EpinephrineDrugbanksmall molecule
DB00692 PhentolamineDrugbanksmall molecule
DB00696 ErgotamineDrugbanksmall molecule
DB00697 TizanidineDrugbanksmall molecule
DB00714 ApomorphineDrugbanksmall molecule
DB00715 ParoxetineDrugbanksmall molecule
DB00726 TrimipramineDrugbanksmall molecule
DB00751 EpinastineDrugbanksmall molecule
DB00797 TolazolineDrugbanksmall molecule
DB00800 FenoldopamDrugbanksmall molecule
DB00852 PseudoephedrineDrugbanksmall molecule
DB00865 BenzphetamineDrugbanksmall molecule
DB00925 PhenoxybenzamineDrugbanksmall molecule
DB00934 MaprotilineDrugbanksmall molecule
DB00935 OxymetazolineDrugbanksmall molecule
DB00964 ApraclonidineDrugbanksmall molecule
DB00968 MethyldopaDrugbanksmall molecule
DB01018 GuanfacineDrugbanksmall molecule
DB01049 Ergoloid mesylateDrugbanksmall molecule
DB01069 PromethazineDrugbanksmall molecule
DB01136 CarvedilolDrugbanksmall molecule
DB01149 NefazodoneDrugbanksmall molecule
DB01151 DesipramineDrugbanksmall molecule
DB01175 EscitalopramDrugbanksmall molecule
DB01186 PergolideDrugbanksmall molecule
DB01200 BromocriptineDrugbanksmall molecule
DB01224 QuetiapineDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01267 PaliperidoneDrugbanksmall molecule
DB01363 Ephedra sinica rootDrugbankbiotech
DB01365 MephentermineDrugbanksmall molecule
DB01392 YohimbineDrugbanksmall molecule
DB01403 MethotrimeprazineDrugbanksmall molecule
DB01472 4-MethoxyamphetamineDrugbanksmall molecule
DB01576 DextroamphetamineDrugbanksmall molecule
DB01577 MetamfetamineDrugbanksmall molecule
DB01608 PericiazineDrugbanksmall molecule
DB01624 ZuclopenthixolDrugbanksmall molecule
DB04846 CeliprololDrugbanksmall molecule
DB04855 DronedaroneDrugbanksmall molecule
DB04948 LofexidineDrugbanksmall molecule
DB05492 Epicept NP-1Drugbanksmall molecule
DB06148 MianserinDrugbanksmall molecule
DB06153 PizotifenDrugbanksmall molecule
DB06216 AsenapineDrugbanksmall molecule
DB06229 OcaperidoneDrugbanksmall molecule
DB06262 DroxidopaDrugbanksmall molecule
DB06623 FlupirtineDrugbanksmall molecule
DB06678 EsmirtazapineDrugbanksmall molecule
DB06694 XylometazolineDrugbanksmall molecule
DB06707 LevonordefrinDrugbanksmall molecule
DB06711 NaphazolineDrugbanksmall molecule
DB08815 LurasidoneDrugbanksmall molecule
DB09167 DosulepinDrugbanksmall molecule
DB09194 EtoperidoneDrugbanksmall molecule
DB09195 LorpiprazoleDrugbanksmall molecule
DB09202 CirazolineDrugbanksmall molecule
DB09205 MoxisylyteDrugbanksmall molecule
DB09229 AranidipineDrugbanksmall molecule
DB09242 MoxonidineDrugbanksmall molecule
DB09244 PirlindoleDrugbanksmall molecule
DB09286 PipamperoneDrugbanksmall molecule
DB09304 SetiptilineDrugbanksmall molecule
DB11124 RacepinephrineDrugbanksmall molecule
DB11273 DihydroergocornineDrugbanksmall molecule
DB11278 DL-MethylephedrineDrugbanksmall molecule
DB11477 XylazineDrugbanksmall molecule
DB11577 Indigotindisulfonic acidDrugbanksmall molecule
DB11738 RilmenidineDrugbanksmall molecule
DB13025 TiaprideDrugbanksmall molecule
DB13345 DihydroergocristineDrugbanksmall molecule
DB14185 Aripiprazole lauroxilDrugbanksmall molecule