Entity Details

Primary name PKHD1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08F94
EntryNamePKHD1_HUMAN
FullNameFibrocystin
TaxID9606
Evidenceevidence at protein level
Length4074
SequenceStatuscomplete
DateCreated2010-05-18
DateModified2021-06-02

Ontological Relatives

GenesPKHD1

GO terms

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GOName
GO:0000132 establishment of mitotic spindle orientation
GO:0000775 chromosome, centromeric region
GO:0001822 kidney development
GO:0001952 regulation of cell-matrix adhesion
GO:0003382 epithelial cell morphogenesis
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005929 cilium
GO:0006874 cellular calcium ion homeostasis
GO:0008284 positive regulation of cell population proliferation
GO:0010824 regulation of centrosome duplication
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0022407 regulation of cell-cell adhesion
GO:0030155 regulation of cell adhesion
GO:0031362 anchored component of external side of plasma membrane
GO:0032006 regulation of TOR signaling
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0036064 ciliary basal body
GO:0038023 signaling receptor activity
GO:0042592 homeostatic process
GO:0043066 negative regulation of apoptotic process
GO:0045216 cell-cell junction organization
GO:0048471 perinuclear region of cytoplasm
GO:0048754 branching morphogenesis of an epithelial tube
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051271 negative regulation of cellular component movement
GO:0051660 establishment of centrosome localization
GO:0051898 negative regulation of protein kinase B signaling
GO:0060271 cilium assembly
GO:0070062 extracellular exosome
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0072686 mitotic spindle
GO:0090175 regulation of establishment of planar polarity
GO:0097731 9+0 non-motile cilium
GO:0098609 cell-cell adhesion
GO:1904036 negative regulation of epithelial cell apoptotic process
GO:1904054 regulation of cholangiocyte proliferation

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell membrane
Cell projection
Chromosome
Cytoplasm
Endoplasmic reticulum
Golgi apparatus
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR002909 IPT domainDomainDomain
IPR006626 Parallel beta-helix repeatRepeatRepeat
IPR011050 Pectin lyase fold/virulence factorFamilyHomologous superfamily
IPR012334 Pectin lyase foldFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR019316 G8 domainDomainDomain
IPR028839 FibrocystinFamilyFamily
IPR037524 PA14/GLEYA domainDomainDomain
IPR039448 Right handed beta helix domainDomainDomain

Diseases

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