Entity Details

Primary name MYB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10242
EntryNameMYB_HUMAN
FullNameTranscriptional activator Myb
TaxID9606
Evidenceevidence at protein level
Length640
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesMYB

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000278 mitotic cell cycle
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001666 response to hypoxia
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006338 chromatin remodeling
GO:0006355 regulation of transcription, DNA-templated
GO:0016363 nuclear matrix
GO:0032967 positive regulation of collagen biosynthetic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0045624 positive regulation of T-helper cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0051574 positive regulation of histone H3-K9 methylation
GO:0060252 positive regulation of glial cell proliferation
GO:0070301 cellular response to hydrogen peroxide
GO:0071300 cellular response to retinoic acid
GO:0071636 positive regulation of transforming growth factor beta production
GO:1901533 negative regulation of hematopoietic progenitor cell differentiation
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1904899 positive regulation of hepatic stellate cell proliferation
GO:2000491 positive regulation of hepatic stellate cell activation
GO:2000845 positive regulation of testosterone secretion

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001005 SANT/Myb domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR012642 Transcription regulator Wos2-domainDomainDomain
IPR015395 C-myb, C-terminalDomainDomain
IPR017930 Myb domainDomainDomain

Diseases

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Interactions

81 interactions

InteractorPartnerSourcesPublicationsLink
MYB_HUMANNLK_HUMANBioGRID, HPRD, IntAct15082531 15308626 16055500 details
MYB_HUMANHIPK2_HUMANBioGRID, HPRD, IntAct15082531 16055500 details
MYB_HUMANERC2_HUMANBioGRID, IntAct20195357 details
MYB_HUMANNCOR1_HUMANBioGRID, IntAct14761981 20195357 details
MYB_HUMANRENT2_HUMANBioGRID, IntAct20195357 details
MYB_HUMANSUMO1_HUMANBioGRID, I2D20802522 details
MYB_HUMANSUMO2_HUMANBioGRID, I2D20802522 details
MYB_HUMANPML_HUMANBioGRID, HPRD, I2D15194430 20802522 details
MYB_HUMANPIAS1_HUMANBioGRID, Molecular Connections21338522 27032383 details
MYB_HUMANCCND3_HUMANBioGRID, IntAct21988832 details
MYB_HUMANMYOZ2_HUMANBioGRID, IntAct21988832 details
MYB_HUMANPPM1K_HUMANBioGRID, IntAct21988832 details
MYB_HUMANPAIP1_HUMANBioGRID, IntAct32296183 details
MYB_HUMANCBP_HUMANBioGRID, DIP, HPRD11073948 12196545 14761981 16055500 16799563 23980173 details
MYB_HUMANHLF_HUMANBioGRID, IntAct20211142 details
MYB_HUMANSP100_HUMANBioGRID, IntAct20211142 details
MYB_HUMANSMCA2_HUMANBioGRID10619021 details
MYB_HUMANCEBPE_HUMANBioGRID, HPRD10233885 details
MYB_HUMANMAF_HUMANBioGRID, HPRD9566892 details
MYB_HUMANSND1_HUMANBioGRID, HPRD8756344 9809063 details
MYB_HUMANFBXW7_HUMANBioGRID, HPRD18765672 21092141 details
MYB_HUMANZMY11_HUMANBioGRID11244510 details
MYB_HUMANEP300_HUMANBioGRID, HPRD10656693 11585920 15691758 20364308 25740244 29954426 details
MYB_HUMANTIF1B_HUMANBioGRID14761981 details
MYB_HUMANSKI_HUMANBioGRID14761981 details
MYB_HUMANSIN3A_HUMANBioGRID14761981 details
MYB_HUMANUBC9_HUMANBioGRID, HPRD11779867 22910413 27150054 details
MYB_HUMANCHD3_HUMANBioGRID17344210 details
MYB_HUMANRL4_HUMANBioGRID20604807 details
MYB_HUMANRBX1_HUMANBioGRID18765672 details
MYB_HUMANKAT2A_HUMANBioGRID10656693 details
MYB_HUMANH31T_HUMANBioGRID29954426 details
MYB_HUMANH2A1B_HUMANBioGRID29954426 details
MYB_HUMANH2B1B_HUMANBioGRID29954426 details
MYB_HUMANH31_HUMANBioGRID29954426 details
MYB_HUMANH4_HUMANBioGRID29954426 details
MYB_HUMANTTF2_HUMANHPRD12927788 details
MYB_HUMANZFHX3_HUMANHPRD10318867 details
MYB_HUMANCNOT9_HUMANHPRD15209511 details
MYB_HUMANCLH1_HUMANMINT18548008 details
MYB_HUMANLIN9_HUMANMINT18548008 details
MYB_HUMANCOX7B_HUMANIntAct20195357 details
MYB_HUMANSDC2_HUMANIntAct20195357 details
MYB_HUMANZC3H1_HUMANIntAct20195357 details
MYB_HUMANPTMS_HUMANIntAct20195357 details
MYB_HUMANKMT2E_HUMANIntAct20195357 details
MYB_HUMANSET1A_HUMANIntAct20195357 details
MYB_HUMANNCAM2_HUMANIntAct20195357 details
MYB_HUMANBEX3_HUMANIntAct20195357 details
MYB_HUMANNBPFE_HUMANIntAct20195357 details
MYB_HUMANADA22_HUMANIntAct20195357 details
MYB_HUMANKIF2A_HUMANIntAct20195357 details
MYB_HUMANFBXL5_HUMANIntAct20195357 details
MYB_HUMANPCD17_HUMANIntAct20195357 details
MYB_HUMANTAL1_HUMANDIP25394790 details
MYB_HUMANNUCL_HUMANBioGRID, HPRD10660576 details
MYB_HUMANCEBPB_HUMANBioGRID, HPRD11792321 details
MYB_HUMANPAX5_HUMANBioGRID, HPRD11781241 details
MYB_HUMANKMT2A_HUMANBioGRID20093773 details
MYB_HUMANWDR5_HUMANBioGRID20093773 details
MYB_HUMANRBBP5_HUMANBioGRID20093773 details
MYB_HUMANASH2L_HUMANBioGRID20093773 details
MYB_HUMANMEN1_HUMANBioGRID20093773 details
MYB_HUMANPARP1_HUMANBioGRID18945670 details
MYB_HUMANKAT2B_HUMANBioGRID20364308 details
MYB_HUMANLEF1_HUMANBioGRID21795403 details
MYB_HUMANKAT5_HUMANBioGRID22110127 details
MYB_HUMANGATA3_HUMANBioGRID22039304 details
MYB_HUMANSTA5A_HUMANBioGRID19036881 details
MYB_HUMANTRAF6_HUMANBioGRID18093978 27150054 details
MYB_HUMANFBXW5_HUMANBioGRID, HPRD18765672 22910413 details
MYB_HUMANDDB1_HUMANBioGRID22910413 details
MYB_HUMANCUL4A_HUMANBioGRID22910413 details
MYB_HUMANHSP7C_HUMANBioGRID23333597 details
MYB_HUMANBMI1_HUMANBioGRID32453568 details
MYB_HUMANMK01_HUMANHPRD8960373 details
MYB_HUMANMBB1A_HUMANHPRD8302594 9447996 details
MYB_HUMANCSK21_HUMANHPRD11313925 details
MYB_HUMANFBXW2_HUMANHPRD18765672 details
MYB_HUMANSKP2_HUMANHPRD18765672 details
MYB_HUMANFBW1A_HUMANHPRD18765672 details