Entity Details

Primary name LYAG_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10253
EntryNameLYAG_HUMAN
FullNameLysosomal alpha-glucosidase
TaxID9606
Evidenceevidence at protein level
Length952
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesGAA

GO terms

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GOName
GO:0000023 maltose metabolic process
GO:0002026 regulation of the force of heart contraction
GO:0002086 diaphragm contraction
GO:0003007 heart morphogenesis
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004558 alpha-1,4-glucosidase activity
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0005980 glycogen catabolic process
GO:0005985 sucrose metabolic process
GO:0006006 glucose metabolic process
GO:0007040 lysosome organization
GO:0007626 locomotory behavior
GO:0009888 tissue development
GO:0016020 membrane
GO:0030246 carbohydrate binding
GO:0032450 maltose alpha-glucosidase activity
GO:0035577 azurophil granule membrane
GO:0043181 vacuolar sequestering
GO:0043202 lysosomal lumen
GO:0043231 intracellular membrane-bounded organelle
GO:0043312 neutrophil degranulation
GO:0046716 muscle cell cellular homeostasis
GO:0050884 neuromuscular process controlling posture
GO:0050885 neuromuscular process controlling balance
GO:0060048 cardiac muscle contraction
GO:0070062 extracellular exosome
GO:0070821 tertiary granule membrane
GO:0101003 ficolin-1-rich granule membrane

Subcellular Location

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Subcellular Location
Lysosome
Lysosome membrane

Domains

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DomainNameCategoryType
IPR000322 Glycoside hydrolase family 31FamilyFamily
IPR000519 P-type trefoil domainDomainDomain
IPR011013 Galactose mutarotase-like domain superfamilyFamilyHomologous superfamily
IPR013780 Glycosyl hydrolase, all-betaFamilyHomologous superfamily
IPR017853 Glycoside hydrolase superfamilyFamilyHomologous superfamily
IPR017957 P-type trefoil, conserved siteSiteConserved site
IPR025887 Glycoside hydrolase family 31, N-terminal domainDomainDomain
IPR030458 Glycosyl hydrolases family 31, active siteSiteActive site
IPR030459 Glycosyl hydrolases family 31, conserved siteSiteConserved site
IPR031727 Galactose mutarotase, N-terminal barrelDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00284 AcarboseDrugbanksmall molecule
DB00491 MiglitolDrugbanksmall molecule
DB05200 AT2220Drugbanksmall molecule
DB14962 Trastuzumab deruxtecanDrugbankbiotech