Entity Details

Primary name CFTR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP13569
EntryNameCFTR_HUMAN
FullNameCystic fibrosis transmembrane conductance regulator
TaxID9606
Evidenceevidence at protein level
Length1480
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesCFTR

GO terms

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GOName
GO:0005254 chloride channel activity
GO:0005260 intracellularly ATP-gated chloride channel activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006695 cholesterol biosynthetic process
GO:0006904 vesicle docking involved in exocytosis
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0015106 bicarbonate transmembrane transporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015701 bicarbonate transport
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0016579 protein deubiquitination
GO:0016853 isomerase activity
GO:0016887 ATP hydrolysis activity
GO:0019869 chloride channel inhibitor activity
GO:0019899 enzyme binding
GO:0030165 PDZ domain binding
GO:0030301 cholesterol transport
GO:0030660 Golgi-associated vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031901 early endosome membrane
GO:0032991 protein-containing complex
GO:0034707 chloride channel complex
GO:0034976 response to endoplasmic reticulum stress
GO:0035377 transepithelial water transport
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0035973 aggrephagy
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0045921 positive regulation of exocytosis
GO:0048240 sperm capacitation
GO:0050891 multicellular organismal water homeostasis
GO:0051087 chaperone binding
GO:0051454 intracellular pH elevation
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane
GO:0055085 transmembrane transport
GO:0060081 membrane hyperpolarization
GO:0061024 membrane organization
GO:0071320 cellular response to cAMP
GO:0106138 Sec61 translocon complex binding
GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity
GO:1902476 chloride transmembrane transport
GO:1902943 positive regulation of voltage-gated chloride channel activity
GO:1904322 cellular response to forskolin

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell membrane
Early endosome membrane
Endoplasmic reticulum membrane
Nucleus
Recycling endosome membrane

Domains

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DomainNameCategoryType
IPR003439 ABC transporter-like, ATP-binding domainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR009147 Cystic fibrosis transmembrane conductance regulatorFamilyFamily
IPR011527 ABC transporter type 1, transmembrane domainDomainDomain
IPR017871 ABC transporter-like, conserved siteSiteConserved site
IPR025837 CFTR regulator domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036640 ABC transporter type 1, transmembrane domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00171 ATPDrugbanksmall molecule
DB00887 BumetanideDrugbanksmall molecule
DB01016 GlyburideDrugbanksmall molecule
DB01050 IbuprofenDrugbanksmall molecule
DB02587 ColforsinDrugbanksmall molecule
DB04395 Phosphoaminophosphonic Acid-Adenylate EsterDrugbanksmall molecule
DB04522 DexfosfoserineDrugbanksmall molecule
DB04941 CrofelemerDrugbanksmall molecule
DB06266 LonidamineDrugbanksmall molecule
DB08820 IvacaftorDrugbanksmall molecule
DB09213 DexibuprofenDrugbanksmall molecule
DB09280 LumacaftorDrugbanksmall molecule
DB11712 TezacaftorDrugbanksmall molecule
DB15444 ElexacaftorDrugbanksmall molecule

Interactions

75 interactions

InteractorPartnerSourcesPublicationsLink
CFTR_HUMANNHRF1_HUMANBioGRID, DIP, HPRD, IntAct, MINT10852925 11158634 12403779 12471024 12615054 15553237 17110338 17244609 19446522 26618866 28360110 9613608 9671706 9677412 details
CFTR_HUMANCLCN3_HUMANBioGRID, IntAct12471024 details
CFTR_HUMANNHRF2_HUMANBioGRID, HPRD, IntAct, MINT10893422 12369822 15553237 16203867 17110338 26618866 28360110 9671706 details
CFTR_HUMANNHRF3_HUMANBioGRID, HPRD, IntAct, MINT11051556 12471024 12615054 15553237 18045536 details
CFTR_HUMANHSP7C_HUMANBioGRID, IntAct10075921 10666020 10982807 11146634 15611333 16857740 17110338 17272822 21697503 23990462 26618866 29924966 details
CFTR_HUMANHS90A_HUMANBioGRID, IntAct10982807 17110338 17272822 18556464 29924966 details
CFTR_HUMANAAPK1_HUMANBioGRID, HPRD10862786 20861072 details
CFTR_HUMANCHIP_HUMANBioGRID11146634 15215316 15611333 19056735 19098309 21898230 31596601 details
CFTR_HUMAN2AAA_HUMANBioGRID, IntAct, MINT15936019 17110338 26618866 29924966 details
CFTR_HUMANKCNN4_HUMANIntAct27092946 details
CFTR_HUMANKAPCA_HUMANBioGRID, HPRD1377674 17272822 details
CFTR_HUMAN2AAB_HUMANBioGRID, HPRD15936019 17110338 26618866 details
CFTR_HUMANCFTR_HUMANBioGRID, HPRD, IntAct, MINT10893422 11051556 11707463 12471024 17110338 26618866 28360110 29924966 details
CFTR_HUMANSTX1A_HUMANBioGRID, HPRD12209004 9384384 details
CFTR_HUMANMARH2_HUMANBioGRID23818989 27308891 details
CFTR_HUMANAAKG1_HUMANIntAct27092946 details
CFTR_HUMANGOPC_HUMANBioGRID, HPRD, IntAct11707463 12471024 28360110 details
CFTR_HUMANUBC9_HUMANBioGRID23155000 26627832 details
CFTR_HUMANK2C8_HUMANIntAct22038833 details
CFTR_HUMANNHRF4_HUMANBioGRID, HPRD12615054 1553237 details
CFTR_HUMANDNJC5_HUMANBioGRID, HPRD12039948 16857740 details
CFTR_HUMANGORS2_HUMANIntAct21884936 details
CFTR_HUMANSNP23_HUMANBioGRID, HPRD12209004 details
CFTR_HUMANNHS_HUMANBioGRID14595111 details
CFTR_HUMANSELS_HUMANBioGRID29555962 details
CFTR_HUMANRNF5_HUMANBioGRID, HPRD, IntAct16901789 19269966 21594788 details
CFTR_HUMANAHSA1_HUMANBioGRID, IntAct17110338 18556464 26618866 29924966 details
CFTR_HUMANCALU_HUMANBioGRID, IntAct17110338 22768251 26618866 29924966 details
CFTR_HUMANRAB5A_HUMANBioGRID, IntAct19398555 21455491 26618866 details
CFTR_HUMANHDAC6_HUMANBioGRID14675537 22069321 31501480 details
CFTR_HUMANHSPB2_HUMANBioGRID23155000 details
CFTR_HUMANDERL1_HUMANBioGRID, HPRD, IntAct16901789 16954204 18555783 26618866 details
CFTR_HUMANTERA_HUMANBioGRID, IntAct16621797 16954204 17110338 17272822 18216283 19828134 26618866 29924966 details
CFTR_HUMANS26A9_HUMANIntAct28360110 details
CFTR_HUMANHSP74_HUMANBioGRID17272822 18556464 18716059 19098309 26618866 details
CFTR_HUMANRB11A_HUMANBioGRID, IntAct19398555 21455491 details
CFTR_HUMANUBP10_HUMANBioGRID, IntAct19398555 20215869 21455491 22904170 details
CFTR_HUMANCBL_HUMANBioGRID20525683 22467879 27261451 details
CFTR_HUMANUBE3A_HUMANBioGRID, IntAct17110338 19233847 details
CFTR_HUMANHSPB1_HUMANBioGRID, IntAct17110338 23155000 26618866 26627832 29924966 details
CFTR_HUMANANO1_HUMANI2D22178883 details
CFTR_HUMANKPCE_HUMANBioGRID, HPRD11956211 details
CFTR_HUMANBCR_HUMANBioGRID, IntAct, MINT15494376 17110338 details
CFTR_HUMANDNJA1_HUMANBioGRID, HPRD, IntAct10075921 11146634 17110338 26618866 29924966 details
CFTR_HUMANAT2A2_HUMANBioGRID, IntAct17110338 25661196 26618866 details
CFTR_HUMANEEA1_HUMANBioGRID, IntAct23686137 29924966 details
CFTR_HUMANNEDD4_HUMANBioGRID, IntAct19617352 25384981 29924966 details
CFTR_HUMANBAG1_HUMANBioGRID23178238 details
CFTR_HUMANCALX_HUMANBioGRID, HPRD, IntAct, MINT12208510 16546175 17110338 18716059 26618866 29924966 details
CFTR_HUMANDAB2_HUMANBioGRID, IntAct17110338 20351096 details
CFTR_HUMANMRP4_HUMANBioGRID18045536 details
CFTR_HUMANJAK1_HUMANBioGRID27261451 details
CFTR_HUMANSL9A6_HUMANHPRD11707463 details
CFTR_HUMANACTB_HUMANIntAct22038833 25712891 29924966 details
CFTR_HUMANAP2A_HUMANBioGRID20351096 details
CFTR_HUMANKGP1_HUMANHPRD1377674 details
CFTR_HUMANSTIP1_HUMANDIP20534503 details
CFTR_HUMANSQSTM_HUMANBioGRID, IntAct20711182 23686137 29924966 details
CFTR_HUMANEZRI_HUMANBioGRID, HPRD, IntAct10893422 26618866 29924966 details
CFTR_HUMANS4A7_HUMANBioGRID, HPRD12403779 details
CFTR_HUMANS4A8_HUMANHPRD12403779 details
CFTR_HUMANUBP19_HUMANBioGRID, MINT19465887 details
CFTR_HUMANKPCA_HUMANHPRD1377674 details
CFTR_HUMANLPAR2_HUMANIntAct16203867 details
CFTR_HUMANDNJB1_HUMANBioGRID, IntAct10075921 17110338 26618866 details
CFTR_HUMANBAP31_HUMANBioGRID, IntAct18555783 details
CFTR_HUMANKCNJ1_HUMANBioGRID14604981 details
CFTR_HUMANMYO6_HUMANBioGRID, IntAct20351096 26618866 29924966 details
CFTR_HUMANAMFR_HUMANBioGRID18216283 19828134 26618866 details
CFTR_HUMANPSA3_HUMANBioGRID16390870 26618866 details
CFTR_HUMANJKAMP_HUMANBioGRID19269966 details
CFTR_HUMANS26A8_HUMANUniProt22121115 details
CFTR_HUMANRN185_HUMANBioGRID24019521 details
CFTR_HUMANKAP2_HUMANHPRD10799517 details
CFTR_HUMANCOMD1_HUMANBioGRID21483833 details