Entity Details

Primary name LYAM3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP16109
EntryNameLYAM3_HUMAN
FullNameP-selectin
TaxID9606
Evidenceevidence at protein level
Length830
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesSELP

GO terms

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GOName
GO:0001530 lipopolysaccharide binding
GO:0002576 platelet degranulation
GO:0002687 positive regulation of leukocyte migration
GO:0005509 calcium ion binding
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007159 leukocyte cell-cell adhesion
GO:0008201 heparin binding
GO:0009897 external side of plasma membrane
GO:0010572 positive regulation of platelet activation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0031088 platelet dense granule membrane
GO:0031092 platelet alpha granule membrane
GO:0032496 response to lipopolysaccharide
GO:0033623 regulation of integrin activation
GO:0033691 sialic acid binding
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0042806 fucose binding
GO:0043208 glycosphingolipid binding
GO:0048306 calcium-dependent protein binding
GO:0050829 defense response to Gram-negative bacterium
GO:0050900 leukocyte migration
GO:0050901 leukocyte tethering or rolling
GO:0070492 oligosaccharide binding
GO:1903238 positive regulation of leukocyte tethering or rolling

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000436 Sushi/SCR/CCP domainDomainDomain
IPR000742 EGF-like domainDomainDomain
IPR001304 C-type lectin-likeDomainDomain
IPR002396 Selectin superfamilyFamilyFamily
IPR016186 C-type lectin-like/link domain superfamilyFamilyHomologous superfamily
IPR016187 C-type lectin foldFamilyHomologous superfamily
IPR018378 C-type lectin, conserved siteSiteConserved site
IPR033991 Selectin, C-type lectin-like domainDomainDomain
IPR035976 Sushi/SCR/CCP superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
601367 OMIMIschemic stroke (ISCHSTR)A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01109 HeparinDrugbanksmall molecule
DB03721 N-acetyl-alpha-neuraminic acidDrugbanksmall molecule
DB06779 DalteparinDrugbanksmall molecule
DB08813 NadroparinDrugbanksmall molecule
DB15271 CrizanlizumabDrugbankbiotech