Entity Details

Primary name F261_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP16118
EntryNameF261_HUMAN
FullName6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
TaxID9606
Evidenceevidence at protein level
Length471
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesPFKFB1

GO terms

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GOName
GO:0003873 6-phosphofructo-2-kinase activity
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0006000 fructose metabolic process
GO:0006003 fructose 2,6-bisphosphate metabolic process
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0019900 kinase binding
GO:0031100 animal organ regeneration
GO:0032868 response to insulin
GO:0033133 positive regulation of glucokinase activity
GO:0033762 response to glucagon
GO:0042594 response to starvation
GO:0042802 identical protein binding
GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex
GO:0045820 negative regulation of glycolytic process
GO:0045821 positive regulation of glycolytic process
GO:0051384 response to glucocorticoid
GO:0051591 response to cAMP
GO:0070095 fructose-6-phosphate binding

Subcellular Location

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Domains

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DomainNameCategoryType
IPR001345 Phosphoglycerate/bisphosphoglycerate mutase, active siteSiteActive site
IPR003094 Fructose-2,6-bisphosphataseFamilyFamily
IPR013078 Histidine phosphatase superfamily, clade-1FamilyFamily
IPR013079 6-phosphofructo-2-kinaseDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR029033 Histidine phosphatase superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02393 D-Gluco-2,5-Anhydro-1-Deoxy-1-Phosphonohexitol-6-PhosphateDrugbanksmall molecule
DB02515 sn-glycerol 3-phosphateDrugbanksmall molecule
DB02930 Adenosine 5'-[gamma-thio]triphosphateDrugbanksmall molecule
DB04137 Guanosine-5'-TriphosphateDrugbanksmall molecule
DB04493 Fructose-6-phosphateDrugbanksmall molecule
DB13749 Magnesium gluconateSwissprotsmall molecule