Entity Details

Primary name CTLA4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP16410
EntryNameCTLA4_HUMAN
FullNameCytotoxic T-lymphocyte protein 4
TaxID9606
Evidenceevidence at protein level
Length223
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesCTLA4

GO terms

Show/Hide Table
GOName
GO:0002250 adaptive immune response
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006955 immune response
GO:0006974 cellular response to DNA damage stimulus
GO:0009897 external side of plasma membrane
GO:0030889 negative regulation of B cell proliferation
GO:0031295 T cell costimulation
GO:0042130 negative regulation of T cell proliferation
GO:0043065 positive regulation of apoptotic process
GO:0045334 clathrin-coated endocytic vesicle
GO:0045589 regulation of regulatory T cell differentiation
GO:0045590 negative regulation of regulatory T cell differentiation
GO:0048471 perinuclear region of cytoplasm
GO:0050777 negative regulation of immune response
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0098636 protein complex involved in cell adhesion

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR003599 Immunoglobulin subtypeDomainDomain
IPR008096 Cytotoxic T-lymphocyte antigen 4FamilyFamily
IPR013106 Immunoglobulin V-set domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR040216 Cytotoxic T-lymphocyte protein 4/CD28FamilyFamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB06186 IpilimumabDrugbankbiotech
DB11771 TremelimumabDrugbankbiotech