Entity Details

Primary name PTN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP18031
EntryNamePTN1_HUMAN
FullNameTyrosine-protein phosphatase non-receptor type 1
TaxID9606
Evidenceevidence at protein level
Length435
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesPTPN1

GO terms

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GOName
GO:0003723 RNA binding
GO:0004725 protein tyrosine phosphatase activity
GO:0005158 insulin receptor binding
GO:0005759 mitochondrial matrix
GO:0005769 early endosome
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0006470 protein dephosphorylation
GO:0007257 obsolete activation of JUN kinase activity
GO:0008270 zinc ion binding
GO:0008286 insulin receptor signaling pathway
GO:0009966 regulation of signal transduction
GO:0009968 negative regulation of signal transduction
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030061 mitochondrial crista
GO:0030100 regulation of endocytosis
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0030971 receptor tyrosine kinase binding
GO:0031532 actin cytoskeleton reorganization
GO:0032991 protein-containing complex
GO:0033157 regulation of intracellular protein transport
GO:0034620 cellular response to unfolded protein
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035791 platelet-derived growth factor receptor-beta signaling pathway
GO:0036498 IRE1-mediated unfolded protein response
GO:0043407 negative regulation of MAP kinase activity
GO:0045296 cadherin binding
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046875 ephrin receptor binding
GO:0051721 protein phosphatase 2A binding
GO:0060338 regulation of type I interferon-mediated signaling pathway
GO:0060397 growth hormone receptor signaling pathway via JAK-STAT
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0097443 sorting endosome
GO:0098554 cytoplasmic side of endoplasmic reticulum membrane
GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903896 positive regulation of IRE1-mediated unfolded protein response
GO:1903898 negative regulation of PERK-mediated unfolded protein response
GO:1990264 peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
GO:2000646 positive regulation of receptor catabolic process

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR000242 PTP type protein phosphataseDomainDomain
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR003595 Protein-tyrosine phosphatase, catalyticDomainDomain
IPR012265 Protein-tyrosine phosphatase, non-receptor type-1/2FamilyFamily
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01734 3-(Oxalyl-Amino)-Naphthalene-2-Carboxylic AcidDrugbanksmall molecule
DB01820 2-{[4-(2-Acetylamino-2-pentylcarbamoyl-ethyl)-naphthalen-1-YL]-oxalyl-amino}-benzoic acidDrugbanksmall molecule
DB02014 5-(2-Fluoro-5-{(1E)-3-[3-hydroxy-2-(methoxycarbonyl)phenoxy]-1-propen-1-yl}phenyl)-1,2-oxazole-3-carboxylic acidDrugbanksmall molecule
DB02072 2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Thiopyran-3-Carboxylic AcidDrugbanksmall molecule
DB02259 3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid (4-Sulfamoyl-Phenyl)-AmideDrugbanksmall molecule
DB02420 [[4-(Aminomethyl)Phenyl]Amino]Oxo-Acetic Acid,Drugbanksmall molecule
DB02436 {4-[(2S)-2-({[(1S)-1-Carboxy-2-phenylethyl]carbamoyl}amino)-3-oxo-3-(pentylamino)propyl]phenoxy}malonic acidDrugbanksmall molecule
DB02615 Compound 19Drugbanksmall molecule
DB02620 3-(4-{2-[2-(2-bromo-acetylamino)-ethyldisulfanyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-pyrazine-2-carboxylic acidDrugbanksmall molecule
DB02622 2-(Oxalyl-Amino)-Benzoic AcidDrugbanksmall molecule
DB02651 {[2-(1h-1,2,3-Benzotriazol-1-Yl)-2-(3,4-Difluorophenyl)Propane-1,3-Diyl]Bis[4,1-Phenylene(Difluoromethylene)]}Bis(Phosphonic Acid)Drugbanksmall molecule
DB02662 Novo Nordisk a/S CompoundDrugbanksmall molecule
DB02784 N-(Bromoacetyl)-beta-alanyl-N-(2-{4-[(carboxycarbonyl)amino]phenyl}ethyl)-L-serinamideDrugbanksmall molecule
DB02827 7-(1,1-Dioxo-1h-Benzo[D]Isothiazol-3-Yloxymethyl)-2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic AcidDrugbanksmall molecule
DB02977 PNU177836Drugbanksmall molecule
DB03102 2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic AcidDrugbanksmall molecule
DB03154 {[7-(Difluoro-Phosphono-Methyl)-Naphthalen-2-Yl]-Difluoro-Methyl}-Phosphonic AcidDrugbanksmall molecule
DB03311 3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid [4-(Thiazol-2-Ylsulfamoyl)-Phenyl]-AmideDrugbanksmall molecule
DB03483 (4S)-5-[[(2S)-1-[[(2S)-1-Amino-3-[4-[difluoro(phosphono)methyl]phenyl]-1-oxopropan-2-yl]amino]-3-[4-[difluoro(phosphono)methyl]phenyl]-1-oxopropan-2-yl]amino]-4-benzamido-5-oxopentanoic acidDrugbanksmall molecule
DB03557 4-[[(2S)-1-[[6-[(1-Amino-1-oxo-3-sulfanylpropan-2-yl)amino]-6-oxohexyl]amino]-3-[4-[difluoro(phosphono)methyl]phenyl]-1-oxopropan-2-yl]amino]-3-[[2-[4-[difluoro(phosphono)methyl]phenyl]acetyl]amino]-4-oxobutanoic acidDrugbanksmall molecule
DB03661 L-cysteic acidDrugbanksmall molecule
DB03670 2-(Oxalyl-Amino)-4,5,6,7-Tetrahydro-Thieno[2,3-C]Pyridine-3-Carboxylic AcidDrugbanksmall molecule
DB03714 4-Carbamoyl-4-{[6-(Difluoro-Phosphono-Methyl)-Naphthalene-2-Carbonyl]-Amino}-Butyric AcidDrugbanksmall molecule
DB03982 Compound 5, 2-(Naphthalen-1-Yl-Oxalyl-Amino)-BenzoicacidDrugbanksmall molecule
DB04001 6-(Oxalyl-Amino)-1h-Indole-5-Carboxylic AcidDrugbanksmall molecule
DB04088 2-[{4-[(2S)-2-{[(Allyloxy)carbonyl]amino}-3-({4-[3-hydroxy-2-(methoxycarbonyl)phenoxy]butyl}amino)-3-oxopropyl]phenyl}(carboxycarbonyl)amino]benzoic acidDrugbanksmall molecule
DB04142 3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid DimethylamideDrugbanksmall molecule
DB04204 [(4-{4-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Butyl}-Phenyl)-Difluoro-Methyl]-Phosphonic AcidDrugbanksmall molecule
DB04285 {4-[(2s,4e)-2-(1,3-Benzothiazol-2-Yl)-2-(1h-1,2,3-Benzotriazol-1-Yl)-5-Phenylpent-4-Enyl]Phenyl}(Difluoro)Methylphosphonic AcidDrugbanksmall molecule
DB04525 N-(3-Carboxypropanoyl)-L-phenylalanyl-3-carboxy-O-(carboxymethyl)-N-pentyl-L-tyrosinamideDrugbanksmall molecule
DB04800 1-METHYL-3-PHENYL-1H-PYRAZOL-5-YLSULFAMIC ACIDDrugbanksmall molecule
DB05506 ISIS 113715Drugbanksmall molecule
DB06333 TrodusquemineDrugbanksmall molecule
DB06521 ErtiprotafibDrugbanksmall molecule
DB06829 4-BROMO-3-(CARBOXYMETHOXY)-5-[3-(CYCLOHEXYLAMINO)PHENYL]THIOPHENE-2-CARBOXYLIC ACIDDrugbanksmall molecule
DB06887 [(3S)-3-(Methylcarbamoyl)-2-{[(2-methyl-2-propanyl)oxy]carbonyl}-1,2,3,4-tetrahydro-7-isoquinolinyl]sulfamic acidDrugbanksmall molecule
DB07130 4-BROMO-3-(CARBOXYMETHOXY)-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACIDDrugbanksmall molecule
DB07134 5-(4-CHLORO-5-PHENYL-3-THIENYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDEDrugbanksmall molecule
DB07197 4-BROMO-3-(CARBOXYMETHOXY)-5-(4-HYDROXYPHENYL)THIOPHENE-2-CARBOXYLIC ACIDDrugbanksmall molecule
DB07263 [{2-bromo-4-[(2R)-3-oxo-2,3-diphenylpropyl]phenyl}(difluoro)methyl]phosphonic acidDrugbanksmall molecule
DB07289 5-[3-(BENZYLAMINO)PHENYL]-4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACIDDrugbanksmall molecule
DB07295 2-[(7-HYDROXY-NAPHTHALEN-1-YL)-OXALYL-AMINO]-BENZOIC ACIDDrugbanksmall molecule
DB07298 3-(CARBOXYMETHOXY)THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACIDDrugbanksmall molecule
DB07480 4-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZENDrugbanksmall molecule
DB07651 N-ACETYL-L-PHENYLALANYL-4-[DIFLUORO(PHOSPHONO)METHYL]-L-PHENYLALANINAMIDEDrugbanksmall molecule
DB07719 [(3R)-3-(Methylcarbamoyl)-2-{[(2-methyl-2-propanyl)oxy]carbonyl}-1,2,3,4-tetrahydro-7-isoquinolinyl]sulfamic acidDrugbanksmall molecule
DB07730 5-(3-HYDROXYPHENYL)ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDEDrugbanksmall molecule
DB08001 5-(3-{3-[3-HYDROXY-2-(METHOXYCARBONYL)PHENOXY]PROPENYL}PHENYL)-4-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLIC ACIDDrugbanksmall molecule
DB08003 ISOTHIAZOLIDINONE ANALOGDrugbanksmall molecule
DB08147 4-[3-(dibenzylamino)phenyl]-2,4-dioxobutanoic acidDrugbanksmall molecule
DB08371 p-Benzoyl-L-phenylalanineDrugbanksmall molecule
DB08397 6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACIDDrugbanksmall molecule
DB08549 (3R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID BENZYL ESTERDrugbanksmall molecule
DB08591 5-(4-METHOXYBIPHENYL-3-YL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDEDrugbanksmall molecule
DB08593 1,2,5-THIADIAZOLIDIN-3-ONE-1,1-DIOXIDEDrugbanksmall molecule
DB08783 (4-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl}phenyl)methaneseleninic acidDrugbanksmall molecule

Interactions

87 interactions

InteractorPartnerSourcesPublicationsLink
PTN1_HUMANINSR_HUMANBioGRID, DIP, HPRD, IntAct, MINT11163213 11506178 11579209 11726652 12237455 12634852 14722096 15588987 16271887 16582879 16926280 17092689 17159996 17481567 19029027 21806020 8826975 8999839 9355745 details
PTN1_HUMANACTN1_HUMANHPRD, IntAct16291744 details
PTN1_HUMANGHR_HUMANBioGRID, IntAct12907755 details
PTN1_HUMANCSK21_HUMANBioGRID, HPRD, MINT8491187 9600099 details
PTN1_HUMANSRC_HUMANBioGRID, HPRD, MINT11007774 12468645 12857726 15866871 16115959 16537444 17092689 17974954 8647855 9261115 9600099 details
PTN1_HUMANGRB2_HUMANBioGRID, HPRD, IntAct, MINT10660596 12388170 27432908 31980649 8940134 details
PTN1_HUMANTRPV6_HUMANHPRD, MINT15894168 17197020 details
PTN1_HUMANJAK2_HUMANBioGRID, HPRD, MINT11694501 11970898 15821101 21806020 details
PTN1_HUMANSTAT3_HUMANBioGRID, MINT11970898 15821101 details
PTN1_HUMANBCAR1_HUMANBioGRID, HPRD, MINT10889023 15588985 15866871 8940134 9407132 9418872 details
PTN1_HUMANIGF1R_HUMANBioGRID, HPRD, MINT15976035 16926280 8999839 details
PTN1_HUMANCAV1_HUMANBioGRID, HPRD, MINT12176037 16388599 details
PTN1_HUMANMET_HUMANIntAct, MINT16537444 18579758 22789536 details
PTN1_HUMANABL1_HUMANMINT16537444 details
PTN1_HUMANGSK3B_HUMANBioGRID, HPRD, MINT7514173 details
PTN1_HUMANESR1_HUMANHPRD, MINT7539106 details
PTN1_HUMANEGFR_HUMANBioGRID, HPRD, IntAct, MINT10889023 11506178 12573287 24658140 25402006 25796184 31980649 7540771 7693694 8621392 9050838 9355745 details
PTN1_HUMANPGFRB_HUMANHPRD, IntAct, MINT12614164 19167335 7545675 9355745 details
PTN1_HUMANIKBA_HUMANHPRD, MINT8940099 details
PTN1_HUMANBCR_HUMANHPRD, MINT9566916 details
PTN1_HUMANLAT_HUMANBioGRID, HPRD, MINT12857726 details
PTN1_HUMANEPOR_HUMANMINT14527337 details
PTN1_HUMANKPCG_HUMANMINT17092689 details
PTN1_HUMANPTN1_HUMANMINT11506178 details
PTN1_HUMANIRS1_HUMANBioGRID, HPRD, MINT10660596 11579209 details
PTN1_HUMANSTA5A_HUMANBioGRID, HPRD, MINT12237455 details
PTN1_HUMANNTRK1_HUMANBioGRID, HPRD, MINT12237455 details
PTN1_HUMANNTRK3_HUMANBioGRID, HPRD, MINT12237455 details
PTN1_HUMANLTK_HUMANBioGRID, HPRD, MINT12237455 details
PTN1_HUMANSTA5B_HUMANBioGRID, HPRD, MINT12237455 details
PTN1_HUMANCAN1_HUMANMINT19712109 9407132 details
PTN1_HUMANCAN2_HUMANHPRD, MINT9407132 details
PTN1_HUMANCLK1_HUMANHPRD, MINT10480872 11579209 details
PTN1_HUMANCLK2_HUMANBioGRID, HPRD, MINT10480872 11579209 details
PTN1_HUMANROS1_HUMANMINT17416557 details
PTN1_HUMANASSY_HUMANBioGRID, IntAct21988832 details
PTN1_HUMANITB1_HUMANBioGRID, MINT21806020 32877691 details
PTN1_HUMANAGR3_HUMANBioGRID, MINT25640309 details
PTN1_HUMANBCAS3_HUMANBioGRID, MINT25640309 details
PTN1_HUMANCASC3_HUMANBioGRID, MINT25640309 details
PTN1_HUMANCASZ1_HUMANBioGRID, MINT25640309 details
PTN1_HUMANCCL5_HUMANBioGRID, MINT25640309 details
PTN1_HUMANCAD13_HUMANBioGRID, MINT25640309 details
PTN1_HUMANDIRA3_HUMANBioGRID, MINT25640309 details
PTN1_HUMANLRAT2_HUMANBioGRID, MINT25640309 details
PTN1_HUMANKLK7_HUMANBioGRID, MINT25640309 details
PTN1_HUMANMRC2_HUMANBioGRID, MINT25640309 details
PTN1_HUMANRHBT2_HUMANBioGRID, MINT25640309 details
PTN1_HUMANSNAI1_HUMANBioGRID, MINT25640309 details
PTN1_HUMANVPS45_HUMANBioGRID, MINT25640309 details
PTN1_HUMANTHRSP_HUMANBioGRID, MINT25640309 details
PTN1_HUMANPIGP_HUMANBioGRID, IntAct32296183 details
PTN1_HUMANTM86B_HUMANBioGRID, IntAct32296183 details
PTN1_HUMANTIDC1_HUMANBioGRID, IntAct32296183 details
PTN1_HUMANAQP6_HUMANBioGRID, IntAct32296183 details
PTN1_HUMANELOV4_HUMANBioGRID, IntAct32296183 details
PTN1_HUMANTM41A_HUMANBioGRID, IntAct32296183 details
PTN1_HUMANEPS15_HUMANDIP25728925 details
PTN1_HUMANCRK_HUMANBioGRID8940134 details
PTN1_HUMANCTNB1_HUMANBioGRID, HPRD12377785 details
PTN1_HUMANNTRK2_HUMANBioGRID, HPRD12237455 25288805 details
PTN1_HUMANSTAM2_HUMANBioGRID20504764 details
PTN1_HUMANCOP1_HUMANBioGRID23439647 details
PTN1_HUMANFGFR1_HUMANBioGRID25760602 details
PTN1_HUMANTMM31_HUMANBioGRID32296183 details
PTN1_HUMANPPIP1_HUMANMINT9857189 details
PTN1_HUMANPIAS1_HUMANHPRD, IntAct17159996 details
PTN1_HUMANITB3_HUMANMINT16115959 details
PTN1_HUMANSRC8_HUMANMINT18387954 details
PTN1_HUMANTYK2_HUMANBioGRID, HPRD, MINT11694501 details
PTN1_HUMANB3AT_HUMANMINT8615784 details
PTN1_HUMANRHOB_HUMANMINT14722096 details
PTN1_HUMANRMD3_HUMANBioGRID, IntAct20627780 21972092 25862004 32877691 details
PTN1_HUMANTHIO_HUMANMINT24976139 details
PTN1_HUMANATP4A_HUMANBioGRID17255364 details
PTN1_HUMANIL1B_HUMANBioGRID23439647 details
PTN1_HUMANHDAC6_HUMANBioGRID29278704 details
PTN1_HUMANRHBL4_HUMANBioGRID31177093 details
PTN1_HUMANST7_HUMANBioGRID29395067 32877691 details
PTN1_HUMANMK01_HUMANHPRD12082107 details
PTN1_HUMANRRAS2_HUMANHPRD11788587 details
PTN1_HUMANGLRX1_HUMANHPRD10350489 details
PTN1_HUMANPIN1_HUMANHPRD9499405 details
PTN1_HUMANCADH2_HUMANHPRD11106648 12377785 details
PTN1_HUMANCSK22_HUMANHPRD8491187 9600099 details
PTN1_HUMANCDK1_HUMANHPRD8491187 9600099 details
PTN1_HUMANAKT1_HUMANHPRD11579209 details