Entity Details

Primary name PLCG1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19174
EntryNamePLCG1_HUMAN
FullName1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
TaxID9606
Evidenceevidence at protein level
Length1290
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesPLCG1

GO terms

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GOName
GO:0001701 in utero embryonic development
GO:0001726 ruffle
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0005168 neurotrophin TRKA receptor binding
GO:0005509 calcium ion binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007411 axon guidance
GO:0008180 COP9 signalosome
GO:0009395 phospholipid catabolic process
GO:0010634 positive regulation of epithelial cell migration
GO:0010863 positive regulation of phospholipase C activity
GO:0016032 viral process
GO:0016477 cell migration
GO:0019722 calcium-mediated signaling
GO:0019901 protein kinase binding
GO:0030027 lamellipodium
GO:0030971 receptor tyrosine kinase binding
GO:0035254 glutamate receptor binding
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042995 cell projection
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043647 inositol phosphate metabolic process
GO:0045766 positive regulation of angiogenesis
GO:0046488 phosphatidylinositol metabolic process
GO:0050429 calcium-dependent phospholipase C activity
GO:0050804 modulation of chemical synaptic transmission
GO:0050852 T cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098978 glutamatergic synapse
GO:1905564 positive regulation of vascular endothelial cell proliferation
GO:2000353 positive regulation of endothelial cell apoptotic process

Subcellular Location

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Subcellular Location
Cell projection

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000909 Phosphatidylinositol-specific phospholipase C, X domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001192 Phosphoinositide phospholipase C familyFamilyFamily
IPR001452 SH3 domainDomainDomain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR016279 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gammaFamilyFamily
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamilyFamilyHomologous superfamily
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR028380 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1FamilyFamily
IPR035023 PLC-gamma, C-terminal SH2 domainDomainDomain
IPR035024 PLC-gamma, N-terminal SH2 domainDomainDomain
IPR035724 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domainDomainDomain
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

204 interactions

InteractorPartnerSourcesPublicationsLink
PLCG1_HUMANKHDR1_HUMANBioGRID, HPRD, IntAct10467411 11960376 14647465 31413325 7537265 7799925 8977179 9045636 9743338 details
PLCG1_HUMANERBB2_HUMANBioGRID, HPRD, MINT16273093 1676673 1683701 22973453 details
PLCG1_HUMANEGFR_HUMANBioGRID, HPRD, MINT11983899 12061819 12601080 12803489 14568990 15144186 16273093 1689310 19605547 22973453 24797263 25754235 7682059 7693694 7993895 8657103 8885868 9020117 9207933 9756944 details
PLCG1_HUMANERBB3_HUMANBioGRID, MINT16273093 22973453 details
PLCG1_HUMANLAT_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10811803 11368773 16467851 16938345 24642916 27221712 7544353 9489702 9729044 details
PLCG1_HUMANASAP2_HUMANIntAct17474147 details
PLCG1_HUMANABL2_HUMANIntAct17474147 details
PLCG1_HUMANRIN3_HUMANBioGRID, IntAct17474147 32552912 details
PLCG1_HUMANSHAN2_HUMANIntAct17474147 details
PLCG1_HUMANM4K1_HUMANIntAct17474147 details
PLCG1_HUMANSOS2_HUMANBioGRID, HPRD, IntAct10940929 17474147 details
PLCG1_HUMANASAP1_HUMANIntAct17474147 details
PLCG1_HUMANSOS1_HUMANBioGRID, HPRD, IntAct, MINT10913276 10940929 17474147 9020117 details
PLCG1_HUMANDUS15_HUMANIntAct17474147 details
PLCG1_HUMANSHAN3_HUMANIntAct17474147 details
PLCG1_HUMANFCG2B_HUMANIntAct17474147 details
PLCG1_HUMANSNX17_HUMANIntAct17474147 details
PLCG1_HUMANDLX4_HUMANIntAct17474147 details
PLCG1_HUMANICAL_HUMANIntAct17474147 details
PLCG1_HUMANTRAIP_HUMANIntAct17474147 details
PLCG1_HUMANPDIA2_HUMANIntAct17474147 details
PLCG1_HUMANS23A1_HUMANIntAct17474147 details
PLCG1_HUMANARHGB_HUMANIntAct17474147 details
PLCG1_HUMANEXTL3_HUMANIntAct17474147 details
PLCG1_HUMANRRAS_HUMANIntAct17474147 details
PLCG1_HUMANRL13_HUMANIntAct17474147 details
PLCG1_HUMANEFS_HUMANIntAct17474147 details
PLCG1_HUMANRGS7_HUMANIntAct17474147 details
PLCG1_HUMANGHR_HUMANBioGRID, IntAct17474147 9632636 details
PLCG1_HUMANRYR1_HUMANIntAct17474147 details
PLCG1_HUMANCKAP5_HUMANIntAct17474147 details
PLCG1_HUMANJAK2_HUMANBioGRID, IntAct14978237 17474147 details
PLCG1_HUMANID4_HUMANIntAct17474147 details
PLCG1_HUMANFLNB_HUMANIntAct17474147 details
PLCG1_HUMANFLNA_HUMANIntAct17474147 details
PLCG1_HUMANIL3RA_HUMANIntAct17474147 details
PLCG1_HUMANABL1_HUMANBioGRID, HPRD, IntAct10708759 1383690 17474147 details
PLCG1_HUMANSUV92_HUMANIntAct17474147 details
PLCG1_HUMANSC24B_HUMANIntAct17474147 details
PLCG1_HUMANZP2_HUMANIntAct17474147 details
PLCG1_HUMANFCG2C_HUMANIntAct17474147 details
PLCG1_HUMANPHAR2_HUMANIntAct17474147 details
PLCG1_HUMANCSMD2_HUMANIntAct17474147 details
PLCG1_HUMANANT3_HUMANIntAct17474147 details
PLCG1_HUMANFANCA_HUMANIntAct17474147 details
PLCG1_HUMANTGON2_HUMANIntAct17474147 details
PLCG1_HUMANCAF1A_HUMANIntAct17474147 details
PLCG1_HUMANMAP4_HUMANIntAct17474147 details
PLCG1_HUMANI20L2_HUMANIntAct17474147 details
PLCG1_HUMANTDRD1_HUMANIntAct17474147 details
PLCG1_HUMANAFF2_HUMANIntAct17474147 details
PLCG1_HUMANAIRE_HUMANIntAct17474147 details
PLCG1_HUMANDNLI3_HUMANIntAct17474147 details
PLCG1_HUMANNELFB_HUMANIntAct17474147 details
PLCG1_HUMANSNX7_HUMANIntAct17474147 details
PLCG1_HUMANRAG1_HUMANIntAct17474147 details
PLCG1_HUMANDTBP1_HUMANIntAct17474147 details
PLCG1_HUMANAKAP2_HUMANIntAct17474147 details
PLCG1_HUMANPERE_HUMANIntAct17474147 details
PLCG1_HUMANFLNC_HUMANIntAct17474147 details
PLCG1_HUMANMEPE_HUMANIntAct17474147 details
PLCG1_HUMANDLGP1_HUMANIntAct17474147 details
PLCG1_HUMANMINT_HUMANIntAct17474147 details
PLCG1_HUMANBICRA_HUMANIntAct17474147 details
PLCG1_HUMANADNP_HUMANIntAct17474147 details
PLCG1_HUMANLIPA4_HUMANIntAct17474147 details
PLCG1_HUMANPAR3_HUMANIntAct17474147 details
PLCG1_HUMANDLGP3_HUMANIntAct17474147 details
PLCG1_HUMANINSR_HUMANBioGRID, HPRD, MINT11796522 14568990 22974441 9593725 details
PLCG1_HUMANGRB2_HUMANBioGRID, HPRD, IntAct, MINT10940929 16038803 21706016 7516467 7629168 9020117 9281317 details
PLCG1_HUMANPLCG1_HUMANBioGRID, MINT11434923 8561895 details
PLCG1_HUMANAKT1_HUMANBioGRID, MINT16525023 details
PLCG1_HUMANRAC1_HUMANMINT19264842 details
PLCG1_HUMANPLD1_HUMANMINT19323535 details
PLCG1_HUMAN3BP2_HUMANBioGRID, HPRD, MINT11390470 15345594 9846481 details
PLCG1_HUMANLCP2_HUMANBioGRID, HPRD, MINT11390650 15929943 16467851 21725281 7706237 details
PLCG1_HUMANSCRB1_HUMANMINT14570588 details
PLCG1_HUMANABI1_HUMANMINT20598684 details
PLCG1_HUMANPGFRB_HUMANBioGRID, DIP, HPRD, IntAct, MINT11896612 1396585 15641795 22974441 23063561 23397142 7678051 8443409 9797459 details
PLCG1_HUMANFGFR1_HUMANBioGRID, DIP, HPRD, IntAct, MINT12601080 15117958 1656221 1689310 18022941 19665973 20932831 23063561 25241761 8321198 9660748 details
PLCG1_HUMANPGFRA_HUMANBioGRID, HPRD, IntAct, MINT25241761 7535778 7682895 details
PLCG1_HUMANKIT_HUMANBioGRID, HPRD, IntAct, MINT11071635 14647465 24728074 25241761 7536744 7537096 details
PLCG1_HUMANVGFR2_HUMANBioGRID, HPRD, MINT12598525 9398617 details
PLCG1_HUMANUFO_HUMANHPRD, MINT9178760 details
PLCG1_HUMANNTRK1_HUMANBioGRID, HPRD, MINT10092678 10708759 1400471 1715690 25921289 8384556 9856458 details
PLCG1_HUMANRET_HUMANBioGRID, HPRD, IntAct, MINT16153436 25241761 32062451 8628282 details
PLCG1_HUMANVILI_HUMANHPRD, UniProt12937273 16921170 17229814 details
PLCG1_HUMANNELL1_HUMANMINT21723284 details
PLCG1_HUMANFGFR2_HUMANBioGRID, DIP, IntAct15629145 24440983 25241761 details
PLCG1_HUMANCBL_HUMANBioGRID, HPRD, IntAct12061819 12803489 12941616 16467851 16503409 17372230 25241761 9234717 9712732 details
PLCG1_HUMANVGFR1_HUMANBioGRID, HPRD, IntAct11312102 23397142 9299537 9398617 9600074 details
PLCG1_HUMANANDR_HUMANBioGRID, IntAct24728074 details
PLCG1_HUMANGAB1_HUMANBioGRID, HPRD, IntAct11507676 24728074 8596638 details
PLCG1_HUMANMET_HUMANBioGRID, HPRD, IntAct24728074 7513258 8662733 details
PLCG1_HUMANWASP_HUMANbhf-ucl, BioGRID, HPRD8805332 8824280 8892607 details
PLCG1_HUMANCD244_HUMANUniProt24642916 details
PLCG1_HUMANSH21B_HUMANUniProt24642916 details
PLCG1_HUMANCAV1_HUMANBioGRID, DIP20808760 details
PLCG1_HUMANEF1A1_HUMANBioGRID, HPRD11886851 12898421 details
PLCG1_HUMANGIT1_HUMANBioGRID, HPRD14523024 details
PLCG1_HUMANPLD2_HUMANBioGRID, HPRD12646582 details
PLCG1_HUMANVAV_HUMANBioGRID, HPRD16467851 9891995 details
PLCG1_HUMANDOK1_HUMANBioGRID, HPRD11071635 details
PLCG1_HUMANRHOA_HUMANBioGRID, HPRD12071848 details
PLCG1_HUMANPKN2_HUMANBioGRID, HPRD8910519 details
PLCG1_HUMANALK_HUMANBioGRID, HPRD11888936 14968112 9174053 9819383 details
PLCG1_HUMANPAK1_HUMANBioGRID, HPRD12085993 details
PLCG1_HUMANITK_HUMANBioGRID, HPRD10586033 12163161 details
PLCG1_HUMANHNRPQ_HUMANBioGRID9341187 details
PLCG1_HUMANZAP70_HUMANBioGRID, HPRD16467851 7629168 8906806 details
PLCG1_HUMANNTRK2_HUMANBioGRID, HPRD10092678 12074588 12419535 26253177 details
PLCG1_HUMANNTRK3_HUMANBioGRID, HPRD10092678 7657612 details
PLCG1_HUMANTRPM7_HUMANBioGRID, HPRD11941371 details
PLCG1_HUMANTNK1_HUMANBioGRID, HPRD10873601 details
PLCG1_HUMANRACK1_HUMANBioGRID, HPRD8290562 details
PLCG1_HUMANIRS2_HUMANBioGRID, HPRD22974441 9535722 details
PLCG1_HUMANPTPRJ_HUMANBioGRID, HPRD11259588 details
PLCG1_HUMANPICAL_HUMANBioGRID, HPRD10926122 details
PLCG1_HUMANPECA1_HUMANBioGRID, HPRD10350061 details
PLCG1_HUMANTUB_HUMANBioGRID, HPRD10455176 details
PLCG1_HUMANGAB2_HUMANBioGRID10391903 details
PLCG1_HUMANGELS_HUMANBioGRID9164868 details
PLCG1_HUMANBAG3_HUMANBioGRID, HPRD10980614 21233200 details
PLCG1_HUMANEPHB2_HUMANBioGRID9632142 details
PLCG1_HUMANEPOR_HUMANBioGRID, HPRD15329338 15644415 15953601 details
PLCG1_HUMANNCAM1_HUMANBioGRID23061666 details
PLCG1_HUMANNPM_HUMANBioGRID9819383 details
PLCG1_HUMANTRI14_HUMANBioGRID29053956 details
PLCG1_HUMANTAU_HUMANBioGRID18467332 9592050 details
PLCG1_HUMANANM8_HUMANBioGRID17925405 details
PLCG1_HUMANERBB4_HUMANBioGRID22973453 details
PLCG1_HUMANTRPC3_HUMANHPRD15744307 15766521 details
PLCG1_HUMANCD22_HUMANBioGRID, HPRD, IntAct8627166 details
PLCG1_HUMANRHOU_HUMANHPRD, MINT15556869 details
PLCG1_HUMANRASA1_HUMANBioGRID, MINT8977179 9020117 9743338 details
PLCG1_HUMANPTN11_HUMANHPRD, MINT15563458 9020117 details
PLCG1_HUMANP85A_HUMANMINT9020117 details
PLCG1_HUMANDDIT4_HUMANMINT19557001 details
PLCG1_HUMANKSYK_HUMANBioGRID, HPRD, MINT15144186 1689310 7682059 7831290 8657103 8885868 details
PLCG1_HUMANAGTR1_HUMANHPRD, MINT9516477 details
PLCG1_HUMANHCK_HUMANHPRD, IntAct10586033 15144186 1689310 23397142 7682059 8657103 8885868 details
PLCG1_HUMANFAK1_HUMANBioGRID, IntAct10430888 23397142 details
PLCG1_HUMANTHMS1_HUMANIntAct21189249 23460737 details
PLCG1_HUMANNFAT5_HUMANDIP20080774 details
PLCG1_HUMANDDR1_HUMANHPRD, MINT10783152 22057045 details
PLCG1_HUMANEPHA4_HUMANIntAct31413325 details
PLCG1_HUMANPK3CA_HUMANBioGRID, IntAct31585087 8561895 details
PLCG1_HUMANLYAM2_HUMANBioGRID, HPRD12960351 details
PLCG1_HUMANDGKZ_HUMANBioGRID, HPRD12890670 details
PLCG1_HUMANSRC_HUMANBioGRID, HPRD1689310 7510703 7682059 8657103 8885868 details
PLCG1_HUMANSHC1_HUMANBioGRID, HPRD10652211 8155326 8662733 details
PLCG1_HUMANSHB_HUMANBioGRID, HPRD10488157 12084069 details
PLCG1_HUMANPDGFA_HUMANBioGRID8443409 details
PLCG1_HUMANKPCD1_HUMANBioGRID, HPRD8885868 details
PLCG1_HUMANRHG32_HUMANBioGRID, HPRD12454018 details
PLCG1_HUMANNTAL_HUMANBioGRID, HPRD12514734 14722116 details
PLCG1_HUMANSH2B3_HUMANBioGRID8649391 details
PLCG1_HUMANRON_HUMANBioGRID, HPRD8918464 details
PLCG1_HUMANLTK_HUMANBioGRID8084603 details
PLCG1_HUMANPRKN_HUMANBioGRID18671761 details
PLCG1_HUMANPLXB1_HUMANBioGRID19805522 details
PLCG1_HUMANPLXB2_HUMANBioGRID19805522 details
PLCG1_HUMANARHG2_HUMANBioGRID19805522 details
PLCG1_HUMANKCC2A_HUMANBioGRID18292392 details
PLCG1_HUMANBLNK_HUMANBioGRID, HPRD10684856 9697839 details
PLCG1_HUMANIBTK_HUMANBioGRID18596081 details
PLCG1_HUMANPML_HUMANBioGRID17419608 details
PLCG1_HUMANSPY1_HUMANBioGRID19915061 details
PLCG1_HUMANJAK1_HUMANBioGRID14978237 details
PLCG1_HUMANPTN6_HUMANBioGRID27221712 details
PLCG1_HUMANGRB14_HUMANBioGRID20932831 details
PLCG1_HUMANCISH_HUMANBioGRID29593227 details
PLCG1_HUMANIRS4_HUMANBioGRID18165436 details
PLCG1_HUMANRPGF5_HUMANBioGRID8561895 details
PLCG1_HUMANKPCE_HUMANBioGRID17561374 details
PLCG1_HUMANFYN_HUMANBioGRID, HPRD10586033 14647465 details
PLCG1_HUMANLYN_HUMANHPRD10586033 15144186 1689310 7682059 8657103 8885868 details
PLCG1_HUMANCD28_HUMANHPRD8386518 details
PLCG1_HUMANTF2H1_HUMANHPRD10467411 details
PLCG1_HUMANSYN1_HUMANHPRD10899172 details
PLCG1_HUMANPIPNA_HUMANHPRD7761838 details
PLCG1_HUMANDAB1_HUMANHPRD15062102 details
PLCG1_HUMANAGAP2_HUMANHPRD11823862 details
PLCG1_HUMANVAV3_HUMANHPRD11094073 details
PLCG1_HUMANAP180_HUMANHPRD11779129 details
PLCG1_HUMANUSO1_HUMANHPRD12507498 details
PLCG1_HUMANSOCS7_HUMANHPRD9344857 details
PLCG1_HUMANCATS_HUMANHPRD9164868 details
PLCG1_HUMANBCR_HUMANHPRD1383690 details
PLCG1_HUMANNCK1_HUMANHPRD9314836 details
PLCG1_HUMANARHG5_HUMANHPRD9314836 details
PLCG1_HUMANFGFR4_HUMANHPRD7518429 details
PLCG1_HUMANBTK_HUMANHPRD15184383 details
PLCG1_HUMANTEC_HUMANHPRD10823839 details
PLCG1_HUMANDYN1_HUMANHPRD15252117 details
PLCG1_HUMANGRAP_HUMANHPRD8995379 details
PLCG1_HUMANSH22A_HUMANHPRD10692392 details
PLCG1_HUMANDAPP1_HUMANHPRD10770799 details
PLCG1_HUMANSHIP1_HUMANHPRD15953601 details
PLCG1_HUMANNMDZ1_HUMANHPRD16767099 details
PLCG1_HUMANNMDE2_HUMANHPRD9231720 details
PLCG1_HUMANNMDE1_HUMANHPRD9231720 details
PLCG1_HUMANLIFR_HUMANHPRD7512571 details
PLCG1_HUMANLCK_HUMANHPRD1500851 details