Entity Details

Primary name WT1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19544
EntryNameWT1_HUMAN
FullNameWilms tumor protein
TaxID9606
Evidenceevidence at protein level
Length449
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesWT1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001570 vasculogenesis
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001822 kidney development
GO:0003156 regulation of animal organ formation
GO:0003700 DNA-binding transcription factor activity
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007281 germ cell development
GO:0007356 thorax and anterior abdomen determination
GO:0007507 heart development
GO:0007530 sex determination
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0008380 RNA splicing
GO:0008406 gonad development
GO:0008584 male gonad development
GO:0009888 tissue development
GO:0010385 double-stranded methylated DNA binding
GO:0010628 positive regulation of gene expression
GO:0016607 nuclear speck
GO:0017148 negative regulation of translation
GO:0030308 negative regulation of cell growth
GO:0030325 adrenal gland development
GO:0030539 male genitalia development
GO:0030855 epithelial cell differentiation
GO:0032835 glomerulus development
GO:0032836 glomerular basement membrane development
GO:0035802 adrenal cortex formation
GO:0043010 camera-type eye development
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0044729 hemi-methylated DNA-binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0060231 mesenchymal to epithelial transition
GO:0060421 positive regulation of heart growth
GO:0060539 diaphragm development
GO:0060923 cardiac muscle cell fate commitment
GO:0061032 visceral serous pericardium development
GO:0070742 C2H2 zinc finger domain binding
GO:0071320 cellular response to cAMP
GO:0071371 cellular response to gonadotropin stimulus
GO:0072075 metanephric mesenchyme development
GO:0072112 glomerular visceral epithelial cell differentiation
GO:0072166 posterior mesonephric tubule development
GO:0072207 metanephric epithelium development
GO:0072284 metanephric S-shaped body morphogenesis
GO:0072302 negative regulation of metanephric glomerular mesangial cell proliferation
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1905643 positive regulation of DNA methylation
GO:2000020 positive regulation of male gonad development
GO:2000195 negative regulation of female gonad development
GO:2001076 positive regulation of metanephric ureteric bud development

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus
Nucleus speckle

Domains

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DomainNameCategoryType
IPR000976 Wilm's tumour protein, N-terminalDomainDomain
IPR013087 Zinc finger C2H2-typeDomainDomain
IPR017987 Wilm's tumour proteinFamilyFamily
IPR036236 Zinc finger C2H2 superfamilyFamilyHomologous superfamily

Diseases

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Interactions

78 interactions

InteractorPartnerSourcesPublicationsLink
WT1_HUMANDVL3_HUMANBioGRID, IntAct, MINT19447967 21900206 27229929 details
WT1_HUMANMDM2_HUMANBioGRID, IntAct21988832 details
WT1_HUMANNPM3_HUMANBioGRID, MINT21900206 details
WT1_HUMANTAOK1_HUMANBioGRID, MINT21900206 details
WT1_HUMANZN205_HUMANBioGRID, MINT21900206 details
WT1_HUMANCASZ1_HUMANBioGRID, MINT25640309 details
WT1_HUMANCCL5_HUMANBioGRID, MINT25640309 details
WT1_HUMANDIRA3_HUMANBioGRID, MINT25640309 details
WT1_HUMANKLK7_HUMANBioGRID, MINT25640309 details
WT1_HUMANARY2_HUMANBioGRID, MINT25640309 details
WT1_HUMANTHRSP_HUMANBioGRID, MINT25640309 details
WT1_HUMANKR108_HUMANBioGRID, IntAct25416956 details
WT1_HUMANK1C40_HUMANBioGRID, IntAct25416956 31515488 details
WT1_HUMANDVL2_HUMANBioGRID, IntAct27107012 27229929 details
WT1_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
WT1_HUMANIPO8_HUMANBioGRID, IntAct32296183 details
WT1_HUMANOSBL3_HUMANBioGRID, IntAct32296183 details
WT1_HUMANZRAN1_HUMANBioGRID, IntAct32296183 details
WT1_HUMANBHE40_HUMANBioGRID, IntAct32296183 details
WT1_HUMANKR107_HUMANBioGRID, IntAct27229929 32296183 details
WT1_HUMANPICK1_HUMANBioGRID, IntAct32296183 details
WT1_HUMANHMBX1_HUMANBioGRID, IntAct27229929 32296183 details
WT1_HUMANKR106_HUMANBioGRID, IntAct32296183 details
WT1_HUMANFL2D_HUMANBioGRID, HPRD, IntAct11001926 26071132 32296183 details
WT1_HUMANTRI55_HUMANBioGRID, IntAct31391242 details
WT1_HUMANTET2_HUMANIntAct25601757 details
WT1_HUMANP53_HUMANBioGRID, HPRD, IntAct10744705 25601757 8389468 9556563 details
WT1_HUMANCLAT_HUMANIntAct32814053 details
WT1_HUMANFGFR3_HUMANIntAct32814053 details
WT1_HUMANRASH_HUMANIntAct32814053 details
WT1_HUMANDNJB1_HUMANIntAct32814053 details
WT1_HUMANPECA1_HUMANIntAct32814053 details
WT1_HUMANTGFR2_HUMANIntAct32814053 details
WT1_HUMANSQSTM_HUMANIntAct32814053 details
WT1_HUMANA4_HUMANIntAct32814053 details
WT1_HUMANUBC9_HUMANBioGRID, HPRD8798754 details
WT1_HUMANPAWR_HUMANBioGRID, HPRD8943350 details
WT1_HUMANU2AF2_HUMANBioGRID, HPRD9784496 details
WT1_HUMANCIAO1_HUMANBioGRID, HPRD9556563 details
WT1_HUMANEGR1_HUMANBioGRID19067769 details
WT1_HUMANKR103_HUMANBioGRID25416956 27229929 details
WT1_HUMANCC136_HUMANBioGRID27229929 details
WT1_HUMANCCD33_HUMANBioGRID27229929 details
WT1_HUMANCEP70_HUMANBioGRID27229929 details
WT1_HUMANETV7_HUMANBioGRID27229929 details
WT1_HUMANFAM9B_HUMANBioGRID27229929 details
WT1_HUMANFMR1N_HUMANBioGRID27229929 details
WT1_HUMANGOGA2_HUMANBioGRID27229929 details
WT1_HUMANIDI1_HUMANBioGRID27229929 details
WT1_HUMANIMA3_HUMANBioGRID27229929 details
WT1_HUMANIMA6_HUMANBioGRID27229929 details
WT1_HUMANKR101_HUMANBioGRID27229929 details
WT1_HUMANKR109_HUMANBioGRID27229929 details
WT1_HUMANLDOC1_HUMANBioGRID27229929 details
WT1_HUMANMAGA8_HUMANBioGRID27229929 details
WT1_HUMANRNH2B_HUMANBioGRID27229929 details
WT1_HUMANSERF2_HUMANBioGRID27229929 details
WT1_HUMANTHAP1_HUMANBioGRID27229929 details
WT1_HUMANMYC_HUMANBioGRID28205554 details
WT1_HUMANWT1_HUMANBioGRID28205554 details
WT1_HUMANGLIS2_HUMANBioGRID28205554 details
WT1_HUMANSOX4_HUMANBioGRID28205554 details
WT1_HUMANSTK11_HUMANBioGRID28205554 details
WT1_HUMANTRI63_HUMANBioGRID31391242 details
WT1_HUMANOGT1_HUMANBioGRID32994395 details
WT1_HUMANWTIP_HUMANHPRD14736876 details
WT1_HUMANMEN1_HUMANBioGRID21378168 details
WT1_HUMANSUZ12_HUMANBioGRID21378168 details
WT1_HUMANEZH2_HUMANBioGRID21378168 details
WT1_HUMANDNMT1_HUMANBioGRID21378168 details
WT1_HUMANHSP74_HUMANBioGRID9553041 details
WT1_HUMANPAX2_HUMANHPRD14603255 details
WT1_HUMANCBP_HUMANHPRD11278547 details
WT1_HUMANKAPCA_HUMANHPRD9366517 details
WT1_HUMANP73_HUMANHPRD10744705 details
WT1_HUMANFHL2_HUMANHPRD12151099 details
WT1_HUMANP63_HUMANHPRD10744705 details
WT1_HUMANAREG_HUMANHPRD10490105 details