Entity Details

Primary name TBP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP20226
EntryNameTBP_HUMAN
FullNameTATA-box-binding protein
TaxID9606
Evidenceevidence at protein level
Length339
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesTBP

GO terms

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GOName
GO:0000785 chromatin
GO:0000791 euchromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000995 RNA polymerase III general transcription initiation factor activity
GO:0001046 core promoter sequence-specific DNA binding
GO:0001091 RNA polymerase II general transcription initiation factor binding
GO:0001093 TFIIB-class transcription factor binding
GO:0001939 female pronucleus
GO:0001940 male pronucleus
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005669 transcription factor TFIID complex
GO:0005672 transcription factor TFIIA complex
GO:0005737 cytoplasm
GO:0006352 DNA-templated transcription, initiation
GO:0006361 transcription initiation from RNA polymerase I promoter
GO:0006363 termination of RNA polymerase I transcription
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006383 transcription by RNA polymerase III
GO:0007283 spermatogenesis
GO:0008134 transcription factor binding
GO:0016032 viral process
GO:0016251 RNA polymerase II general transcription initiation factor activity
GO:0017162 aryl hydrocarbon receptor binding
GO:0019899 enzyme binding
GO:0032991 protein-containing complex
GO:0042795 snRNA transcription by RNA polymerase II
GO:0045815 positive regulation of gene expression, epigenetic
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051123 RNA polymerase II preinitiation complex assembly
GO:0097550 transcription preinitiation complex
GO:0140223 general transcription initiation factor activity
GO:1901796 regulation of signal transduction by p53 class mediator

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000814 TATA-box binding proteinFamilyFamily
IPR012295 TBP domain superfamilyFamilyHomologous superfamily
IPR030491 TATA-box binding protein, conserved siteSiteConserved site
IPR033710 TATA-box binding protein, eukaryoticFamilyFamily

Diseases

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Disease IDSourceNameDescription
607136 OMIMSpinocerebellar ataxia 17 (SCA17)Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA17 is an autosomal dominant cerebellar ataxia (ADCA) characterized by widespread cerebral and cerebellar atrophy, dementia and extrapyramidal signs. The molecular defect in SCA17 is the expansion of a CAG repeat in the coding region of TBP. Longer expansions result in earlier onset and more severe clinical manifestations of the disease. The disease is caused by variants affecting the gene represented in this entry.

Interactions

166 interactions

InteractorPartnerSourcesPublicationsLink
TBP_HUMANTF2AA_HUMANBioGRID, HPRD, IntAct11278496 11509574 12941701 17643375 2247058 26186194 28514442 29111974 7724559 7958900 8006019 9603936 details
TBP_HUMANTF2B_HUMANBioGRID, HPIDb, HPRD, IntAct10619841 14963322 15207618 17994014 7671313 8006019 9054408 9159119 details
TBP_HUMANHMGB1_HUMANBioGRID, HPRD, IntAct8006019 9880542 details
TBP_HUMANMDM2_HUMANBioGRID, HPRD, IntAct9271120 9388200 details
TBP_HUMANP53_HUMANBioGRID, HPRD, IntAct, MINT10359315 10601022 11313951 12379483 1465435 7799929 8083962 8395834 8405994 9349482 details
TBP_HUMANTAF1L_HUMANBioGRID, HPRD, IntAct12217962 details
TBP_HUMANWDR62_HUMANBioGRID, HPRD, IntAct16169070 details
TBP_HUMANTAF1_HUMANBioGRID, DIP, HPRD, IntAct, MINT15564746 15870300 17375202 17884155 17967894 18391197 19240132 29111974 31753913 7597030 7680771 8858156 8995708 9153318 9311784 9603525 9660973 9674425 9858607 details
TBP_HUMANTEAD1_HUMANHPRD, MINT8423815 details
TBP_HUMANEDF1_HUMANBioGRID, HPRD, IntAct10567391 10816571 12040021 details
TBP_HUMANFATE1_HUMANBioGRID, HPRD, IntAct16713569 details
TBP_HUMANTF3B_HUMANBioGRID, HPRD, IntAct10921893 11809839 16713569 18391023 26496610 30413534 7624363 details
TBP_HUMANCXXC1_HUMANBioGRID, HPRD, IntAct16713569 details
TBP_HUMANCOQA1_HUMANBioGRID, HPRD, IntAct16713569 details
TBP_HUMANHAP1_HUMANBioGRID, IntAct16713569 details
TBP_HUMANBRF2_HUMANBioGRID, HPRD, IntAct11564744 17353931 details
TBP_HUMANPO3F2_HUMANBioGRID, HPRD, IntAct11029584 details
TBP_HUMANTAF1C_HUMANBioGRID, HPRD, IntAct, MINT17268553 17318177 26496610 7801123 details
TBP_HUMANTAF12_HUMANBioGRID, HPRD, IntAct, MINT17158164 17268553 17967894 19240132 7729427 8663456 9603525 9674425 details
TBP_HUMANTAF1B_HUMANBioGRID, HPRD, IntAct, MINT17318177 26496610 7801123 details
TBP_HUMANTAF1A_HUMANBioGRID, HPRD, IntAct, MINT15315821 17318177 26496610 7801123 details
TBP_HUMANTAF5_HUMANBioGRID, HPRD, IntAct10373431 15870280 17375202 17884155 17967894 19240132 22323595 26344197 7680771 7744009 8858156 9045704 9153318 9311784 9603525 9674425 details
TBP_HUMANT2AG_HUMANBioGRID, HPRD, IntAct29111974 7724559 7958900 8626665 9603936 details
TBP_HUMANTAF4_HUMANBioGRID, IntAct10373431 12665565 17967894 19240132 22323595 22939629 8858156 9153318 9311784 9603525 9674425 details
TBP_HUMANTAF2_HUMANBioGRID, IntAct10373431 17967894 19240132 7680771 details
TBP_HUMANTAF10_HUMANBioGRID, DIP, HPRD, IntAct10373431 15099517 17375202 17967894 19240132 22323595 22939629 23292512 7680771 7744009 7923369 9153318 9603525 9674425 details
TBP_HUMANTAF6_HUMANBioGRID, IntAct12453419 12665565 15870280 17375202 17967894 19240132 22323595 22939629 7680771 8858156 9153318 9311784 9603525 9674425 details
TBP_HUMANTAF7_HUMANBioGRID, IntAct12665565 17158164 19240132 22323595 29111974 9153318 9311784 9603525 details
TBP_HUMANTAF11_HUMANBioGRID, HPRD, IntAct10591645 17375202 17967894 19240132 29111974 7729427 8670810 9153318 9603525 details
TBP_HUMANTAF9_HUMANBioGRID, IntAct11564863 17967894 19240132 22939629 9153318 9674425 details
TBP_HUMANMYC_HUMANBioGRID, HPRD, IntAct15723054 21729782 8755740 details
TBP_HUMANCUED2_HUMANBioGRID, IntAct26186194 28514442 32296183 details
TBP_HUMANTCEA1_HUMANBioGRID, DIP10454562 20562857 9305922 details
TBP_HUMANPRGR_HUMANDIP24909783 details
TBP_HUMANESR1_HUMANBioGRID, HPRD, IntAct11595744 31527615 9259327 details
TBP_HUMANNC2B_HUMANBioGRID, HPRD, IntAct11461703 18838386 25416956 31515488 32296183 details
TBP_HUMANNF2L2_HUMANIntAct32911434 details
TBP_HUMANCDK5_HUMANIntAct32814053 details
TBP_HUMANA4_HUMANIntAct32814053 details
TBP_HUMANTAF13_HUMANBioGRID, HPRD19240132 22939629 29111974 7729427 details
TBP_HUMANCTBP1_HUMANBioGRID11959865 details
TBP_HUMANIKZF1_HUMANBioGRID, HPRD11959865 details
TBP_HUMANNCOA6_HUMANBioGRID10567404 details
TBP_HUMANRPB1_HUMANBioGRID9002523 9159119 9311784 details
TBP_HUMANBTAF1_HUMANBioGRID, HPRD22939629 9159119 9488487 details
TBP_HUMANT2EA_HUMANBioGRID, HPRD11113176 25492609 7926747 9159119 details
TBP_HUMANT2FA_HUMANBioGRID7590250 9159119 9482861 details
TBP_HUMANTF2H4_HUMANBioGRID9159119 details
TBP_HUMANSNPC4_HUMANBioGRID, HPRD12621023 details
TBP_HUMANTF3C2_HUMANBioGRID10373544 details
TBP_HUMANTF3C3_HUMANBioGRID, HPRD10373544 details
TBP_HUMANTF3C4_HUMANBioGRID10373544 details
TBP_HUMANTF3C5_HUMANBioGRID10373544 details
TBP_HUMANRUVB1_HUMANBioGRID, HPRD9843967 details
TBP_HUMANGCR_HUMANBioGRID, HPRD9649342 details
TBP_HUMANMSX1_HUMANBioGRID, HPRD10215616 8700832 9111364 details
TBP_HUMANKDM5A_HUMANBioGRID, HPRD7935440 details
TBP_HUMANJUN_HUMANBioGRID, HPRD16055710 7848298 details
TBP_HUMANNCOA1_HUMANBioGRID, HPRD8754792 details
TBP_HUMANSPIB_HUMANBioGRID, HPRD10196196 details
TBP_HUMANCREM_HUMANBioGRID, HPRD10409662 details
TBP_HUMANREL_HUMANBioGRID, HPRD8413269 details
TBP_HUMANCITE2_HUMANBioGRID10593900 details
TBP_HUMANHSF1_HUMANBioGRID, HPRD11005381 details
TBP_HUMANT2FB_HUMANBioGRID, HPRD8577725 details
TBP_HUMANBCL3_HUMANBioGRID, HPRD9812988 details
TBP_HUMANSNPC2_HUMANBioGRID, HPRD8524284 8633057 details
TBP_HUMANAHR_HUMANBioGRID, HPRD15641800 8794892 details
TBP_HUMANT2EB_HUMANBioGRID, HPRD11113176 9677423 details
TBP_HUMANRXRA_HUMANBioGRID, HPRD7667283 details
TBP_HUMANCREG1_HUMANBioGRID, HPRD9710587 details
TBP_HUMANNFYB_HUMANBioGRID, HPRD9153318 details
TBP_HUMANNFYC_HUMANBioGRID9153318 details
TBP_HUMANFOS_HUMANBioGRID, HPRD16055710 7685215 8065335 details
TBP_HUMANATF4_HUMANBioGRID9295363 details
TBP_HUMANPO2F2_HUMANBioGRID, HPRD8202368 details
TBP_HUMANPO2F1_HUMANBioGRID, HPRD8202368 details
TBP_HUMANRNF4_HUMANBioGRID, HPRD11696545 9710597 details
TBP_HUMANTF65_HUMANBioGRID, HPRD10839990 7706261 9584164 details
TBP_HUMANRPC6_HUMANBioGRID9171375 details
TBP_HUMANPAX6_HUMANBioGRID, HPRD10359315 details
TBP_HUMANPAX3_HUMANBioGRID10359315 details
TBP_HUMANNC2A_HUMANBioGRID, HPRD11461703 15574413 18838386 details
TBP_HUMANFOXF2_HUMANBioGRID, HPRD9722567 details
TBP_HUMANKLF5_HUMANBioGRID9089417 details
TBP_HUMANANDR_HUMANBioGRID9238003 details
TBP_HUMANMCM2_HUMANBioGRID, HPRD12392551 details
TBP_HUMANTF2AY_HUMANBioGRID12107178 details
TBP_HUMANRB_HUMANBioGRID, HPRD11094070 9242374 details
TBP_HUMANTAF3_HUMANBioGRID11438666 19240132 21884934 details
TBP_HUMANBRD2_HUMANBioGRID17111193 31753913 details
TBP_HUMANE2F1_HUMANBioGRID17111193 8255752 9400991 details
TBP_HUMANSPI1_HUMANBioGRID, HPRD11593411 8434021 details
TBP_HUMANHTF4_HUMANBioGRID15333839 details
TBP_HUMANZNF76_HUMANBioGRID, HPRD15280358 16337145 16522640 details
TBP_HUMANREST_HUMANBioGRID15197246 details
TBP_HUMANELF3_HUMANBioGRID10391676 details
TBP_HUMANTAF8_HUMANBioGRID14580349 17375202 17967894 23326349 details
TBP_HUMANSNPC1_HUMANBioGRID, HPRD8524284 details
TBP_HUMANSP1_HUMANBioGRID, HPRD12753906 25363021 details
TBP_HUMANRUVB2_HUMANBioGRID11080158 details
TBP_HUMANHNF4A_HUMANBioGRID9792714 details
TBP_HUMANPAX5_HUMANBioGRID, HPRD10197586 details
TBP_HUMANUBC9_HUMANBioGRID15637059 details
TBP_HUMANGOGA2_HUMANBioGRID25416956 32296183 details
TBP_HUMANADIP_HUMANBioGRID25416956 details
TBP_HUMANH31T_HUMANBioGRID20850016 details
TBP_HUMANYETS2_HUMANBioGRID18838386 details
TBP_HUMANMBD2_HUMANBioGRID25363021 details
TBP_HUMANCTCFL_HUMANBioGRID25363021 details
TBP_HUMANETS1_HUMANBioGRID25363021 details
TBP_HUMANHUWE1_HUMANBioGRID26393420 details
TBP_HUMANCND2_HUMANBioGRID26257282 details
TBP_HUMANSPB5_HUMANBioGRID16049007 details
TBP_HUMANPLAK_HUMANBioGRID14517306 details
TBP_HUMANPSME3_HUMANBioGRID32296183 details
TBP_HUMANHMBX1_HUMANBioGRID32296183 details
TBP_HUMANPIAS1_HUMANHPRD16522640 details
TBP_HUMANPIAS3_HUMANHPRD16522640 details
TBP_HUMANIKBB_HUMANBioGRID, IntAct14743216 26186194 28514442 details
TBP_HUMANSET_HUMANMINT17318177 details
TBP_HUMAN1433E_HUMANHPRD, IntAct10449590 details
TBP_HUMANTAF1D_HUMANBioGRID, IntAct17318177 19615732 26496610 details
TBP_HUMANCDX1_HUMANIntAct17158164 details
TBP_HUMANRPA34_HUMANBioGRID15226435 details
TBP_HUMANTAF7L_HUMANBioGRID, HPRD12665565 details
TBP_HUMANCBX5_HUMANBioGRID11959914 details
TBP_HUMANUBF1_HUMANBioGRID, HPRD8552083 details
TBP_HUMANRRN3_HUMANBioGRID11250903 details
TBP_HUMANTBP_HUMANBioGRID, HPRD10567404 7775442 7801123 8650542 9311784 9603525 9674425 details
TBP_HUMANRPC3_HUMANBioGRID9171375 details
TBP_HUMANDHX9_HUMANBioGRID, HPRD11149922 details
TBP_HUMANPRS7_HUMANBioGRID, HPRD11118327 details
TBP_HUMANMKX_HUMANBioGRID19235719 details
TBP_HUMANSIN3A_HUMANBioGRID12453419 details
TBP_HUMANSMCA2_HUMANBioGRID12453419 details
TBP_HUMANATX7_HUMANBioGRID15932940 details
TBP_HUMANHDAC1_HUMANBioGRID11313951 details
TBP_HUMANSETD7_HUMANBioGRID15099517 details
TBP_HUMANTAF4B_HUMANBioGRID8858156 details
TBP_HUMANCPSF1_HUMANBioGRID9311784 details
TBP_HUMANEP300_HUMANBioGRID8995708 details
TBP_HUMANCBP_HUMANBioGRID8995708 details
TBP_HUMANERCC1_HUMANBioGRID22323595 details
TBP_HUMANTAF9B_HUMANBioGRID15899866 details
TBP_HUMANMUC1_HUMANBioGRID15710329 details
TBP_HUMANICE2_HUMANBioGRID21729782 details
TBP_HUMANGBG12_HUMANBioGRID23326349 details
TBP_HUMANMEF2A_HUMANBioGRID23326349 details
TBP_HUMANGBB2_HUMANBioGRID23326349 details
TBP_HUMANKMT2A_HUMANBioGRID12453419 details
TBP_HUMANC2TA_HUMANBioGRID26871568 details
TBP_HUMANUBP10_HUMANBioGRID26393420 details
TBP_HUMANMED1_HUMANBioGRID18391015 details
TBP_HUMANWDR5_HUMANBioGRID32076268 details
TBP_HUMANCDC27_HUMANBioGRID32076268 details
TBP_HUMANJUND_HUMANHPRD7848298 details
TBP_HUMANTCP4_HUMANHPRD9482861 details
TBP_HUMANNACA_HUMANHPRD8835540 details
TBP_HUMANNCOA3_HUMANHPRD9267036 details
TBP_HUMANTRIP4_HUMANHPRD10454579 details
TBP_HUMANTRAM2_HUMANHPRD14612417 details
TBP_HUMANABT1_HUMANHPRD10648625 details
TBP_HUMANHNRPK_HUMANHPRD8628302 details
TBP_HUMANCAND2_HUMANHPRD10441524 details
TBP_HUMANHD_HUMANHPRD10410676 details