Entity Details

Primary name DDC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP20711
EntryNameDDC_HUMAN
FullNameAromatic-L-amino-acid decarboxylase
TaxID9606
Evidenceevidence at protein level
Length480
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesDDC

GO terms

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GOName
GO:0004058 aromatic-L-amino-acid decarboxylase activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006520 cellular amino acid metabolic process
GO:0006584 catecholamine metabolic process
GO:0007623 circadian rhythm
GO:0008021 synaptic vesicle
GO:0010259 multicellular organism aging
GO:0015842 aminergic neurotransmitter loading into synaptic vesicle
GO:0016597 amino acid binding
GO:0016831 carboxy-lyase activity
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0030170 pyridoxal phosphate binding
GO:0030424 axon
GO:0033076 isoquinoline alkaloid metabolic process
GO:0035690 cellular response to drug
GO:0036467 5-hydroxy-L-tryptophan decarboxylase activity
GO:0036468 L-dopa decarboxylase activity
GO:0042416 dopamine biosynthetic process
GO:0042423 catecholamine biosynthetic process
GO:0042427 serotonin biosynthetic process
GO:0043025 neuronal cell body
GO:0046219 indolalkylamine biosynthetic process
GO:0046684 response to pyrethroid
GO:0052314 phytoalexin metabolic process
GO:0070062 extracellular exosome
GO:0071312 cellular response to alkaloid
GO:0071363 cellular response to growth factor stimulus

Subcellular Location

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Domains

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DomainNameCategoryType
IPR002129 Pyridoxal phosphate-dependent decarboxylaseFamilyFamily
IPR010977 Aromatic-L-amino-acid decarboxylaseFamilyFamily
IPR015421 Pyridoxal phosphate-dependent transferase, major domainFamilyHomologous superfamily
IPR015422 Pyridoxal phosphate-dependent transferase, small domainFamilyHomologous superfamily
IPR015424 Pyridoxal phosphate-dependent transferaseFamilyHomologous superfamily
IPR021115 Pyridoxal-phosphate binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB00114 Pyridoxal phosphateDrugbanksmall molecule
DB00150 TryptophanDrugbanksmall molecule
DB00190 CarbidopaDrugbanksmall molecule
DB00260 CycloserineDrugbanksmall molecule
DB00875 FlupentixolDrugbanksmall molecule
DB00915 AmantadineDrugbanksmall molecule
DB00968 MethyldopaDrugbanksmall molecule
DB01235 LevodopaDrugbanksmall molecule
DB06262 DroxidopaDrugbanksmall molecule
DB12783 BenserazideDrugbanksmall molecule
DB13848 Fluorodopa (18F)Swissprotsmall molecule

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
DDC_HUMANANDR_HUMANHPRD, IntAct12864730 details
DDC_HUMANTF65_HUMANBioGRID, IntAct21988832 details
DDC_HUMANATF6A_HUMANBioGRID, IntAct21988832 details
DDC_HUMANDDC_HUMANDIP22143761 details