Entity Details

Primary name CD3Z_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP20963
EntryNameCD3Z_HUMAN
FullNameT-cell surface glycoprotein CD3 zeta chain
TaxID9606
Evidenceevidence at protein level
Length164
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesCD247

GO terms

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GOName
GO:0002250 adaptive immune response
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004888 transmembrane signaling receptor activity
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0018149 peptide cross-linking
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042101 T cell receptor complex
GO:0042105 alpha-beta T cell receptor complex
GO:0042802 identical protein binding
GO:0050690 regulation of defense response to virus by virus
GO:0050776 regulation of immune response
GO:0050852 T cell receptor signaling pathway
GO:1990782 protein tyrosine kinase binding
GO:2000010 positive regulation of protein localization to cell surface

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR003110 Phosphorylated immunoreceptor signalling ITAMRepeatRepeat
IPR021663 T-cell surface glycoprotein CD3 zeta subunit/High affinity IgE receptor gamma subunitFamilyFamily
IPR024128 T-cell surface glycoprotein CD3 zeta subunitFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00075 MuromonabDrugbankbiotech

Interactions

52 interactions

InteractorPartnerSourcesPublicationsLink
CD3Z_HUMANLCK_HUMANBioGRID, DIP, HPRD, IntAct, MINT14523017 16461343 24463463 26390156 8626561 9047237 details
CD3Z_HUMANCD3Z_HUMANHPRD, IntAct, MINT12356870 17055436 24502978 2845582 details
CD3Z_HUMANPTN22_HUMANBioGRID, HPRD, IntAct16461343 details
CD3Z_HUMANZAP70_HUMANBioGRID, DIP, HPRD, MINT, UniProt10704231 10752619 11353765 15832366 20637659 21957439 22242145 24463463 26390156 30863395 7509083 7528772 7737297 8366117 8647168 8648092 8901551 8906806 9036949 9185620 details
CD3Z_HUMANVTNC_HUMANBioGRID, IntAct21988832 details
CD3Z_HUMANPCGF2_HUMANBioGRID, IntAct21988832 details
CD3Z_HUMANZN281_HUMANBioGRID, IntAct21988832 details
CD3Z_HUMANARRB1_HUMANMINT24502978 details
CD3Z_HUMANSH21A_HUMANIntAct22912825 details
CD3Z_HUMANATX2_HUMANIntAct32814053 details
CD3Z_HUMANU119A_HUMANBioGRID, HPRD14757743 details
CD3Z_HUMANPTPRC_HUMANBioGRID, HPRD7526385 details
CD3Z_HUMANJAK3_HUMANBioGRID, HPRD11349123 details
CD3Z_HUMANCSK_HUMANBioGRID, HPRD8621646 9172452 details
CD3Z_HUMANNCK1_HUMANMINT18320063 details
CD3Z_HUMANSHC1_HUMANBioGRID, HPRD, MINT7544002 8647168 8656061 details
CD3Z_HUMANCCR7_HUMANMINT22922463 details
CD3Z_HUMANCD3E_HUMANBioGRID, IntAct14523017 25241761 details
CD3Z_HUMANDOCK2_HUMANBioGRID, HPRD, IntAct12176041 25241761 details
CD3Z_HUMANNCTR3_HUMANHPRD, IntAct12731048 21552268 details
CD3Z_HUMANSLAP1_HUMANBioGRID, HPRD10449770 details
CD3Z_HUMANNCTR1_HUMANBioGRID, HPRD9625766 details
CD3Z_HUMANGAB2_HUMANBioGRID, HPRD11572860 details
CD3Z_HUMANTRAT1_HUMANBioGRID, HPRD11390434 9687533 details
CD3Z_HUMANSLAP2_HUMANBioGRID, HPRD11891219 details
CD3Z_HUMANSTA5A_HUMANBioGRID, HPRD9880255 details
CD3Z_HUMANSTA5B_HUMANBioGRID, HPRD9880255 details
CD3Z_HUMANTBA1B_HUMANBioGRID15084271 details
CD3Z_HUMANCBL_HUMANBioGRID11353765 details
CD3Z_HUMANLAT_HUMANBioGRID14523017 details
CD3Z_HUMANCD38_HUMANBioGRID14523017 details
CD3Z_HUMANCILK1_HUMANBioGRID8626561 details
CD3Z_HUMANLY6E_HUMANBioGRID, HPRD9575182 details
CD3Z_HUMANRNF41_HUMANBioGRID26390156 details
CD3Z_HUMANP85A_HUMANBioGRID11526404 8647168 details
CD3Z_HUMANSHC3_HUMANBioGRID22242145 details
CD3Z_HUMANFYN_HUMANBioGRID, HPRD1454062 1530920 7589084 8647168 8760790 9368621 details
CD3Z_HUMANUBS3A_HUMANBioGRID31659016 details
CD3Z_HUMANCD28_HUMANHPRD8760790 details
CD3Z_HUMANCD3D_HUMANHPRD9485181 details
CD3Z_HUMANCD2_HUMANHPRD16049493 8977276 details
CD3Z_HUMANTFR1_HUMANHPRD9448136 details
CD3Z_HUMANSH2B3_HUMANHPRD10799879 details
CD3Z_HUMANTIRAP_HUMANHPRD11572860 details
CD3Z_HUMANFCG3A_HUMANHPRD2138330 details
CD3Z_HUMANGRB2_HUMANHPRD7629168 details
CD3Z_HUMANPTN6_HUMANHPRD14672952 details
CD3Z_HUMANPTN3_HUMANHPRD14672952 details
CD3Z_HUMANCD48_HUMANHPRD16049493 details
CD3Z_HUMANCD244_HUMANHPRD16049493 details
CD3Z_HUMANP4K2B_HUMANHPRD16337488 details
CD3Z_HUMANCD5_HUMANHPRD1385158 details