Entity Details

Primary name DRD4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP21917
EntryNameDRD4_HUMAN
FullNameD(4) dopamine receptor
TaxID9606
Evidenceevidence at protein level
Length419
SequenceStatuscomplete
DateCreated1991-05-01
DateModified2021-06-02

Ontological Relatives

GenesDRD4

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0001662 behavioral fear response
GO:0001975 response to amphetamine
GO:0004952 dopamine neurotransmitter receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006874 cellular calcium ion homeostasis
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007212 dopamine receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0008344 adult locomotory behavior
GO:0015459 potassium channel regulator activity
GO:0016020 membrane
GO:0017124 SH3 domain binding
GO:0030425 dendrite
GO:0030594 neurotransmitter receptor activity
GO:0032417 positive regulation of sodium:proton antiporter activity
GO:0033674 positive regulation of kinase activity
GO:0034776 response to histamine
GO:0035176 social behavior
GO:0035240 dopamine binding
GO:0042053 regulation of dopamine metabolic process
GO:0042417 dopamine metabolic process
GO:0042596 fear response
GO:0042752 regulation of circadian rhythm
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0048148 behavioral response to cocaine
GO:0048149 behavioral response to ethanol
GO:0048511 rhythmic process
GO:0050482 arachidonic acid secretion
GO:0050709 negative regulation of protein secretion
GO:0051379 epinephrine binding
GO:0051380 norepinephrine binding
GO:0051586 positive regulation of dopamine uptake involved in synaptic transmission
GO:0060080 inhibitory postsynaptic potential
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization
GO:1901386 negative regulation of voltage-gated calcium channel activity

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000929 Dopamine receptor familyFamilyFamily
IPR002185 Dopamine D4 receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00246 ZiprasidoneDrugbanksmall molecule
DB00248 CabergolineDrugbanksmall molecule
DB00268 RopiniroleDrugbanksmall molecule
DB00334 OlanzapineDrugbanksmall molecule
DB00363 ClozapineDrugbanksmall molecule
DB00408 LoxapineDrugbanksmall molecule
DB00409 RemoxiprideDrugbanksmall molecule
DB00413 PramipexoleDrugbanksmall molecule
DB00477 ChlorpromazineDrugbanksmall molecule
DB00490 BuspironeDrugbanksmall molecule
DB00543 AmoxapineDrugbanksmall molecule
DB00589 LisurideDrugbanksmall molecule
DB00714 ApomorphineDrugbanksmall molecule
DB00988 DopamineDrugbanksmall molecule
DB01049 Ergoloid mesylateDrugbanksmall molecule
DB01186 PergolideDrugbanksmall molecule
DB01200 BromocriptineDrugbanksmall molecule
DB01224 QuetiapineDrugbanksmall molecule
DB01235 LevodopaDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01267 PaliperidoneDrugbanksmall molecule
DB01403 MethotrimeprazineDrugbanksmall molecule
DB04908 FlibanserinDrugbanksmall molecule
DB04946 IloperidoneDrugbanksmall molecule
DB05271 RotigotineDrugbanksmall molecule
DB06216 AsenapineDrugbanksmall molecule
DB06477 SumaniroleDrugbanksmall molecule
DB08922 PerospironeDrugbanksmall molecule
DB09286 PipamperoneDrugbanksmall molecule
DB11275 EpicriptineDrugbanksmall molecule
DB12061 PardoprunoxDrugbanksmall molecule
DB13345 DihydroergocristineDrugbanksmall molecule
DB14185 Aripiprazole lauroxilDrugbanksmall molecule