Entity Details

Primary name UD11_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP22309
EntryNameUD11_HUMAN
FullNameUDP-glucuronosyltransferase 1A1
TaxID9606
Evidenceevidence at protein level
Length533
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-06-02

Ontological Relatives

GenesUGT1A1

GO terms

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GOName
GO:0001889 liver development
GO:0001972 retinoic acid binding
GO:0004857 enzyme inhibitor activity
GO:0005496 steroid binding
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005887 integral component of plasma membrane
GO:0006789 bilirubin conjugation
GO:0006953 acute-phase response
GO:0007584 response to nutrient
GO:0008202 steroid metabolic process
GO:0008210 estrogen metabolic process
GO:0015020 glucuronosyltransferase activity
GO:0017144 drug metabolic process
GO:0019899 enzyme binding
GO:0031100 animal organ regeneration
GO:0032496 response to lipopolysaccharide
GO:0034663 endoplasmic reticulum chaperone complex
GO:0042167 heme catabolic process
GO:0042493 response to drug
GO:0042573 retinoic acid metabolic process
GO:0042594 response to starvation
GO:0042803 protein homodimerization activity
GO:0045922 negative regulation of fatty acid metabolic process
GO:0045939 negative regulation of steroid metabolic process
GO:0046483 heterocycle metabolic process
GO:0046982 protein heterodimerization activity
GO:0048471 perinuclear region of cytoplasm
GO:0051552 flavone metabolic process
GO:0052695 cellular glucuronidation
GO:0052696 flavonoid glucuronidation
GO:0052697 xenobiotic glucuronidation
GO:0070069 cytochrome complex
GO:0070980 biphenyl catabolic process
GO:0071361 cellular response to ethanol
GO:0071385 cellular response to glucocorticoid stimulus
GO:0071392 cellular response to estradiol stimulus
GO:1904224 negative regulation of glucuronosyltransferase activity
GO:2001030 negative regulation of cellular glucuronidation

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR002213 UDP-glucuronosyl/UDP-glucosyltransferaseFamilyFamily
IPR035595 UDP-glycosyltransferase family, conserved siteDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00173 AdenineDrugbanksmall molecule
DB00193 TramadolDrugbanksmall molecule
DB00197 TroglitazoneDrugbanksmall molecule
DB00220 NelfinavirDrugbanksmall molecule
DB00224 IndinavirDrugbanksmall molecule
DB00227 LovastatinDrugbanksmall molecule
DB00252 PhenytoinDrugbanksmall molecule
DB00279 LiothyronineDrugbanksmall molecule
DB00295 MorphineDrugbanksmall molecule
DB00304 DesogestrelDrugbanksmall molecule
DB00313 Valproic acidDrugbanksmall molecule
DB00316 AcetaminophenDrugbanksmall molecule
DB00328 IndomethacinDrugbanksmall molecule
DB00350 MinoxidilDrugbanksmall molecule
DB00398 SorafenibDrugbanksmall molecule
DB00439 CerivastatinDrugbanksmall molecule
DB00451 LevothyroxineDrugbanksmall molecule
DB00455 LoratadineDrugbanksmall molecule
DB00481 RaloxifeneDrugbanksmall molecule
DB00495 ZidovudineDrugbanksmall molecule
DB00503 RitonavirDrugbanksmall molecule
DB00530 ErlotinibDrugbanksmall molecule
DB00555 LamotrigineDrugbanksmall molecule
DB00564 CarbamazepineDrugbanksmall molecule
DB00598 LabetalolDrugbanksmall molecule
DB00625 EfavirenzDrugbanksmall molecule
DB00641 SimvastatinDrugbanksmall molecule
DB00678 LosartanDrugbanksmall molecule
DB00688 Mycophenolate mofetilDrugbanksmall molecule
DB00695 FurosemideDrugbanksmall molecule
DB00704 NaltrexoneDrugbanksmall molecule
DB00712 FlurbiprofenDrugbanksmall molecule
DB00714 ApomorphineDrugbanksmall molecule
DB00762 IrinotecanDrugbanksmall molecule
DB00773 EtoposideDrugbanksmall molecule
DB00783 EstradiolDrugbanksmall molecule
DB00794 PrimidoneDrugbanksmall molecule
DB00818 PropofolDrugbanksmall molecule
DB00870 SuprofenDrugbanksmall molecule
DB00906 TiagabineDrugbanksmall molecule
DB00909 ZonisamideDrugbanksmall molecule
DB00916 MetronidazoleDrugbanksmall molecule
DB00932 TipranavirDrugbanksmall molecule
DB00947 FulvestrantDrugbanksmall molecule
DB00957 NorgestimateDrugbanksmall molecule
DB00973 EzetimibeDrugbanksmall molecule
DB00977 EthinylestradiolDrugbanksmall molecule
DB01009 KetoprofenDrugbanksmall molecule
DB01024 Mycophenolic acidDrugbanksmall molecule
DB01026 KetoconazoleDrugbanksmall molecule
DB01032 ProbenecidDrugbanksmall molecule
DB01045 RifampicinDrugbanksmall molecule
DB01048 AbacavirDrugbanksmall molecule
DB01067 GlipizideDrugbanksmall molecule
DB01072 AtazanavirDrugbanksmall molecule
DB01076 AtorvastatinDrugbanksmall molecule
DB01095 FluvastatinDrugbanksmall molecule
DB01136 CarvedilolDrugbanksmall molecule
DB01174 PhenobarbitalDrugbanksmall molecule
DB01183 NaloxoneDrugbanksmall molecule
DB01241 GemfibrozilDrugbanksmall molecule
DB01420 Testosterone propionateDrugbanksmall molecule
DB01544 FlunitrazepamDrugbanksmall molecule
DB01609 DeferasiroxSwissprotsmall molecule
DB02703 Fusidic acidDrugbanksmall molecule
DB03496 AlvocidibDrugbanksmall molecule
DB04868 NilotinibDrugbanksmall molecule
DB04953 EzogabineDrugbanksmall molecule
DB05018 MigalastatDrugbanksmall molecule
DB05039 IndacaterolDrugbanksmall molecule
DB06077 LumateperoneDrugbanksmall molecule
DB06210 EltrombopagDrugbanksmall molecule
DB06510 MuraglitazarDrugbanksmall molecule
DB06589 PazopanibDrugbanksmall molecule
DB06626 AxitinibDrugbanksmall molecule
DB06741 GavestinelDrugbanksmall molecule
DB06817 RaltegravirDrugbanksmall molecule
DB08896 RegorafenibDrugbanksmall molecule
DB08930 DolutegravirDrugbanksmall molecule
DB09079 NintedanibDrugbanksmall molecule
DB09119 Eslicarbazepine acetateDrugbanksmall molecule
DB09213 DexibuprofenDrugbanksmall molecule
DB09276 Sodium aurothiomalateSwissprotsmall molecule
DB09288 PropacetamolDrugbanksmall molecule
DB09297 ParitaprevirDrugbanksmall molecule
DB09298 SilibininSwissprotsmall molecule
DB11689 SelumetinibDrugbanksmall molecule
DB11796 FostemsavirDrugbanksmall molecule
DB11799 BictegravirDrugbanksmall molecule
DB11827 ErtugliflozinDrugbanksmall molecule
DB11943 DelafloxacinDrugbanksmall molecule
DB11963 DacomitinibDrugbanksmall molecule
DB11967 BinimetinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB12020 TecovirimatDrugbanksmall molecule
DB12070 LetermovirDrugbanksmall molecule
DB12332 RucaparibDrugbanksmall molecule
DB12893 Sacituzumab govitecanDrugbankbiotech
DB12978 PexidartinibDrugbanksmall molecule
DB13874 EnasidenibDrugbanksmall molecule
DB13878 PibrentasvirDrugbanksmall molecule
DB13879 GlecaprevirDrugbanksmall molecule
DB13952 Estradiol acetateDrugbanksmall molecule
DB13953 Estradiol benzoateDrugbanksmall molecule
DB13954 Estradiol cypionateDrugbanksmall molecule
DB13955 Estradiol dienanthateDrugbanksmall molecule
DB13956 Estradiol valerateDrugbanksmall molecule
DB14575 EslicarbazepineDrugbanksmall molecule
DB14635 Curcumin sulfateDrugbanksmall molecule
DB15328 UbrogepantDrugbanksmall molecule