Entity Details

Primary name NK1R_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP25103
EntryNameNK1R_HUMAN
FullNameSubstance-P receptor
TaxID9606
Evidenceevidence at protein level
Length407
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesTACR1

GO terms

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GOName
GO:0004995 tachykinin receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006954 inflammatory response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007217 tachykinin receptor signaling pathway
GO:0009582 detection of abiotic stimulus
GO:0016496 substance P receptor activity
GO:0036126 sperm flagellum
GO:0048265 response to pain
GO:0061827 sperm head
GO:0070472 regulation of uterine smooth muscle contraction
GO:0097225 sperm midpiece
GO:1902093 positive regulation of flagellated sperm motility

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000046 Neurokinin NK1 receptorFamilyFamily
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR001681 Neurokinin receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00193 TramadolDrugbanksmall molecule
DB00673 AprepitantDrugbanksmall molecule
DB01221 KetamineDrugbanksmall molecule
DB04894 VapreotideDrugbanksmall molecule
DB05072 AV608Drugbanksmall molecule
DB05418 GW 597599Drugbanksmall molecule
DB05421 CP-122721Drugbanksmall molecule
DB05466 R673Drugbanksmall molecule
DB05790 SR 140333Drugbanksmall molecule
DB06634 CasopitantDrugbanksmall molecule
DB09048 NetupitantDrugbanksmall molecule
DB09291 RolapitantDrugbanksmall molecule
DB11949 VestipitantDrugbanksmall molecule
DB12436 VofopitantDrugbanksmall molecule
DB14019 FosnetupitantDrugbanksmall molecule

Interactions

6 interactions