Entity Details

Primary name PYR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP27708
EntryNamePYR1_HUMAN
FullNameCAD protein
TaxID9606
Evidenceevidence at protein level
Length2225
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesCAD

GO terms

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GOName
GO:0001889 liver development
GO:0004070 aspartate carbamoyltransferase activity
GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO:0004151 dihydroorotase activity
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006228 UTP biosynthetic process
GO:0006541 glutamine metabolic process
GO:0006807 nitrogen compound metabolic process
GO:0007507 heart development
GO:0007565 female pregnancy
GO:0007595 lactation
GO:0008270 zinc ion binding
GO:0014075 response to amine
GO:0016020 membrane
GO:0016363 nuclear matrix
GO:0017144 drug metabolic process
GO:0018107 peptidyl-threonine phosphorylation
GO:0019240 citrulline biosynthetic process
GO:0019899 enzyme binding
GO:0031000 response to caffeine
GO:0031100 animal organ regeneration
GO:0032868 response to insulin
GO:0032991 protein-containing complex
GO:0033574 response to testosterone
GO:0035690 cellular response to drug
GO:0042594 response to starvation
GO:0042802 identical protein binding
GO:0042995 cell projection
GO:0043025 neuronal cell body
GO:0043195 terminal bouton
GO:0044205 'de novo' UMP biosynthetic process
GO:0046134 pyrimidine nucleoside biosynthetic process
GO:0046777 protein autophosphorylation
GO:0051414 response to cortisol
GO:0070062 extracellular exosome
GO:0070335 aspartate binding
GO:0071364 cellular response to epidermal growth factor stimulus

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR002082 Aspartate carbamoyltransferaseFamilyFamily
IPR002195 Dihydroorotase, conserved siteSiteConserved site
IPR002474 Carbamoyl-phosphate synthase small subunit, N-terminal domainDomainDomain
IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domainDomainDomain
IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domainDomainDomain
IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domainDomainDomain
IPR006130 Aspartate/ornithine carbamoyltransferaseFamilyFamily
IPR006131 Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domainDomainDomain
IPR006132 Aspartate/ornithine carbamoyltransferase, carbamoyl-P bindingDomainDomain
IPR006274 Carbamoyl-phosphate synthase, small subunitFamilyFamily
IPR006275 Carbamoyl-phosphate synthase, large subunitFamilyFamily
IPR006680 Amidohydrolase-relatedDomainDomain
IPR011059 Metal-dependent hydrolase, composite domain superfamilyFamilyHomologous superfamily
IPR011607 Methylglyoxal synthase-like domainDomainDomain
IPR011761 ATP-grasp foldDomainDomain
IPR013815 ATP-grasp fold, subdomain 1FamilyHomologous superfamily
IPR016185 Pre-ATP-grasp domain superfamilyFamilyHomologous superfamily
IPR017926 Glutamine amidotransferaseDomainDomain
IPR029062 Class I glutamine amidotransferase-likeFamilyHomologous superfamily
IPR032466 Metal-dependent hydrolaseFamilyHomologous superfamily
IPR035686 Carbamoyl-phosphate synthase small subunit, GATase1 domainDomainDomain
IPR036480 Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamilyFamilyHomologous superfamily
IPR036897 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamilyFamilyHomologous superfamily
IPR036901 Aspartate/ornithine carbamoyltransferase superfamilyFamilyHomologous superfamily
IPR036914 Methylglyoxal synthase-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00128 Aspartic acidDrugbanksmall molecule
DB00130 L-GlutamineDrugbanksmall molecule
DB03459 Sparfosic acidDrugbanksmall molecule

Interactions

37 interactions

InteractorPartnerSourcesPublicationsLink
PYR1_HUMANPYR1_HUMANDIP, HPRD11986331 12438317 14523024 24332717 details
PYR1_HUMANHTRA2_HUMANBioGRID17266347 details
PYR1_HUMANNEDD4_HUMANBioGRID16055720 details
PYR1_HUMANSUMO2_HUMANBioGRID19394292 details
PYR1_HUMANRAD9A_HUMANBioGRID15326225 details
PYR1_HUMANPTEN_HUMANBioGRID31685992 details
PYR1_HUMANIKBE_HUMANIntAct14743216 details
PYR1_HUMANNEMO_HUMANIntAct14743216 details
PYR1_HUMANM3K1_HUMANIntAct14743216 details
PYR1_HUMANM3K3_HUMANIntAct14743216 details
PYR1_HUMANNFKB2_HUMANIntAct14743216 details
PYR1_HUMANM3K14_HUMANBioGRID, IntAct14743216 30833792 31980649 details
PYR1_HUMANTF65_HUMANIntAct14743216 details
PYR1_HUMANRELB_HUMANIntAct14743216 details
PYR1_HUMANRIPK1_HUMANIntAct14743216 details
PYR1_HUMANRIPK3_HUMANIntAct14743216 details
PYR1_HUMANTAB2_HUMANIntAct14743216 details
PYR1_HUMANM3K7_HUMANIntAct14743216 details
PYR1_HUMANTNR1A_HUMANIntAct14743216 details
PYR1_HUMANTNR1B_HUMANIntAct14743216 details
PYR1_HUMANTRADD_HUMANIntAct14743216 details
PYR1_HUMANTRAF2_HUMANIntAct14743216 details
PYR1_HUMAN1433Z_HUMANMINT15161933 details
PYR1_HUMANHDAC5_HUMANBioGRID21081666 details
PYR1_HUMANNCOA2_HUMANBioGRID16051665 details
PYR1_HUMANITA4_HUMANBioGRID22623428 details
PYR1_HUMANSPRTN_HUMANBioGRID23254330 details
PYR1_HUMANDERL1_HUMANBioGRID28137758 details
PYR1_HUMANVHL_HUMANBioGRID28775317 details
PYR1_HUMANFAS_HUMANBioGRID28775317 details
PYR1_HUMANISG15_HUMANBioGRID33024031 details
PYR1_HUMANMK01_HUMANHPRD12438317 details
PYR1_HUMANCASP3_HUMANHPRD11854437 details
PYR1_HUMANKAPCA_HUMANHPRD11986331 4092695 details
PYR1_HUMANPP2AA_HUMANHPRD4092695 details
PYR1_HUMANPP1A_HUMANHPRD4092695 details
PYR1_HUMAN1433G_HUMANHPRD15324660 details