Entity Details

Primary name GCH1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP30793
EntryNameGCH1_HUMAN
FullNameGTP cyclohydrolase 1
TaxID9606
Evidenceevidence at protein level
Length250
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesGCH1

GO terms

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GOName
GO:0003924 GTPase activity
GO:0003934 GTP cyclohydrolase I activity
GO:0005509 calcium ion binding
GO:0005525 GTP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006729 tetrahydrobiopterin biosynthetic process
GO:0006809 nitric oxide biosynthetic process
GO:0008217 regulation of blood pressure
GO:0008270 zinc ion binding
GO:0010460 positive regulation of heart rate
GO:0014916 regulation of lung blood pressure
GO:0030742 GTP-dependent protein binding
GO:0031369 translation initiation factor binding
GO:0031410 cytoplasmic vesicle
GO:0031965 nuclear membrane
GO:0032496 response to lipopolysaccharide
GO:0032991 protein-containing complex
GO:0034341 response to interferon-gamma
GO:0034612 response to tumor necrosis factor
GO:0035998 7,8-dihydroneopterin 3'-triphosphate biosynthetic process
GO:0042311 vasodilation
GO:0042416 dopamine biosynthetic process
GO:0042559 pteridine-containing compound biosynthetic process
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0044306 neuron projection terminus
GO:0044877 protein-containing complex binding
GO:0045776 negative regulation of blood pressure
GO:0046146 tetrahydrobiopterin metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0048265 response to pain
GO:0050884 neuromuscular process controlling posture
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051019 mitogen-activated protein kinase binding
GO:0065003 protein-containing complex assembly
GO:2000121 regulation of removal of superoxide radicals

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001474 GTP cyclohydrolase IFamilyFamily
IPR018234 GTP cyclohydrolase I, conserved siteSiteConserved site
IPR020602 GTP cyclohydrolase I domainDomainDomain
IPR043133 GTP cyclohydrolase I, C-terminal/NADPH-dependent 7-cyano-7-deazaguanine reductaseFamilyHomologous superfamily
IPR043134 GTP cyclohydrolase I, N-terminal domainFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02377 GuanineDrugbanksmall molecule

Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
GCH1_HUMANAHSA1_HUMANBioGRID, HPRD, IntAct16696853 details
GCH1_HUMANHSP7C_HUMANBioGRID, HPRD, IntAct16696853 details
GCH1_HUMANRAB26_HUMANBioGRID, HPRD, IntAct16696853 details
GCH1_HUMANCNRP1_HUMANBioGRID, IntAct16696853 details
GCH1_HUMANRLF_HUMANBioGRID, HPRD, IntAct16696853 details
GCH1_HUMANSP3_HUMANBioGRID, IntAct16696853 details
GCH1_HUMANGCH1_HUMANBioGRID, HPRD, IntAct11087827 16696853 2463916 details
GCH1_HUMANGFRP_HUMANBioGRID, HPRD, IntAct16696853 8702680 details
GCH1_HUMANGIT2_HUMANBioGRID, IntAct21988832 details
GCH1_HUMAN1433Z_HUMANBioGRID, IntAct21988832 details
GCH1_HUMANCDC37_HUMANBioGRID, MINT21900206 details
GCH1_HUMANSH3G2_HUMANBioGRID, MINT21900206 details
GCH1_HUMANTNPO2_HUMANBioGRID, IntAct32296183 details
GCH1_HUMANTNPO3_HUMANBioGRID, IntAct32296183 details
GCH1_HUMANAT1B1_HUMANBioGRID, HPRD16696853 details
GCH1_HUMANRP3A_HUMANBioGRID, HPRD7802677 details
GCH1_HUMANPACN3_HUMANBioGRID19294699 details
GCH1_HUMANCALL5_HUMANBioGRID19294699 details
GCH1_HUMANCALL6_HUMANBioGRID19294699 details
GCH1_HUMANRGS19_HUMANBioGRID19294699 details
GCH1_HUMANPPM1B_HUMANBioGRID19294699 details
GCH1_HUMANMP2K4_HUMANBioGRID19294699 details
GCH1_HUMANMP2K5_HUMANBioGRID19294699 details
GCH1_HUMANMK12_HUMANBioGRID19294699 details
GCH1_HUMANMK10_HUMANBioGRID19294699 details
GCH1_HUMANKKCC1_HUMANBioGRID19294699 details
GCH1_HUMANKC1G1_HUMANBioGRID19294699 details
GCH1_HUMANCSK21_HUMANBioGRID19294699 details
GCH1_HUMANCSK2B_HUMANBioGRID19294699 details
GCH1_HUMANKAP2_HUMANBioGRID19294699 details
GCH1_HUMANKAP3_HUMANBioGRID19294699 details