Entity Details

Primary name MRP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP33527
EntryNameMRP1_HUMAN
FullNameMultidrug resistance-associated protein 1
TaxID9606
Evidenceevidence at protein level
Length1531
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesABCC1

GO terms

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GOName
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006691 leukotriene metabolic process
GO:0008559 ABC-type xenobiotic transporter activity
GO:0009235 cobalamin metabolic process
GO:0009925 basal plasma membrane
GO:0015431 ABC-type glutathione S-conjugate transporter activity
GO:0015562 efflux transmembrane transporter activity
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0016887 ATP hydrolysis activity
GO:0034040 ATPase-coupled lipid transmembrane transporter activity
GO:0034634 glutathione transmembrane transporter activity
GO:0034775 glutathione transmembrane transport
GO:0042167 heme catabolic process
GO:0042493 response to drug
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0042908 xenobiotic transport
GO:0042910 xenobiotic transmembrane transporter activity
GO:0045332 phospholipid translocation
GO:0046943 carboxylic acid transmembrane transporter activity
GO:0050729 positive regulation of inflammatory response
GO:0055085 transmembrane transport
GO:0060326 cell chemotaxis
GO:0070062 extracellular exosome
GO:0070633 transepithelial transport
GO:0071716 leukotriene transport
GO:0099039 sphingolipid translocation
GO:0140115 export across plasma membrane
GO:0140359 ABC-type transporter activity
GO:0150104 transport across blood-brain barrier
GO:1904646 cellular response to amyloid-beta
GO:1905039 carboxylic acid transmembrane transport
GO:1990962 xenobiotic transport across blood-brain barrier

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR003439 ABC transporter-like, ATP-binding domainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR005292 Multi drug resistance-associated proteinFamilyFamily
IPR011527 ABC transporter type 1, transmembrane domainDomainDomain
IPR017871 ABC transporter-like, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036640 ABC transporter type 1, transmembrane domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00115 CyanocobalaminDrugbanksmall molecule
DB00143 GlutathioneDrugbanksmall molecule
DB00171 ATPDrugbanksmall molecule
DB00224 IndinavirDrugbanksmall molecule
DB00286 Conjugated estrogensDrugbanksmall molecule
DB00328 IndomethacinDrugbanksmall molecule
DB00345 Aminohippuric acidSwissprotsmall molecule
DB00365 GrepafloxacinDrugbanksmall molecule
DB00396 ProgesteroneDrugbanksmall molecule
DB00399 Zoledronic acidDrugbanksmall molecule
DB00445 EpirubicinDrugbanksmall molecule
DB00503 RitonavirDrugbanksmall molecule
DB00541 VincristineDrugbanksmall molecule
DB00563 MethotrexateDrugbanksmall molecule
DB00570 VinblastineDrugbanksmall molecule
DB00586 DiclofenacDrugbanksmall molecule
DB00602 IvermectinDrugbanksmall molecule
DB00661 VerapamilDrugbanksmall molecule
DB00693 FluoresceinDrugbanksmall molecule
DB00694 DaunorubicinDrugbanksmall molecule
DB00701 AmprenavirDrugbanksmall molecule
DB00709 LamivudineDrugbanksmall molecule
DB00762 IrinotecanDrugbanksmall molecule
DB00773 EtoposideDrugbanksmall molecule
DB00834 MifepristoneDrugbanksmall molecule
DB00845 ClofazimineDrugbanksmall molecule
DB00970 DactinomycinDrugbanksmall molecule
DB00997 DoxorubicinDrugbanksmall molecule
DB01016 GlyburideDrugbanksmall molecule
DB01032 ProbenecidDrugbanksmall molecule
DB01045 RifampicinDrugbanksmall molecule
DB01050 IbuprofenDrugbanksmall molecule
DB01072 AtazanavirDrugbanksmall molecule
DB01076 AtorvastatinDrugbanksmall molecule
DB01138 SulfinpyrazoneDrugbanksmall molecule
DB01165 OfloxacinDrugbanksmall molecule
DB01174 PhenobarbitalDrugbanksmall molecule
DB01177 IdarubicinDrugbanksmall molecule
DB01204 MitoxantroneDrugbanksmall molecule
DB01229 PaclitaxelDrugbanksmall molecule
DB01232 SaquinavirDrugbanksmall molecule
DB01248 DocetaxelDrugbanksmall molecule
DB01645 GenisteinDrugbanksmall molecule
DB01708 PrasteroneDrugbanksmall molecule
DB02375 MyricetinDrugbanksmall molecule
DB02659 Cholic AcidDrugbanksmall molecule
DB03467 NaringeninDrugbanksmall molecule
DB03825 Rhodamine 6GDrugbanksmall molecule
DB04216 QuercetinDrugbanksmall molecule
DB04348 Taurocholic acidDrugbanksmall molecule
DB04851 BiricodarDrugbanksmall molecule
DB05294 VandetanibDrugbanksmall molecule
DB05812 AbirateroneDrugbanksmall molecule
DB06176 RomidepsinDrugbanksmall molecule
DB06335 SaxagliptinDrugbanksmall molecule
DB08855 Leukotriene C4Drugbanksmall molecule
DB08868 FingolimodDrugbanksmall molecule
DB08881 VemurafenibDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB09161 Technetium Tc-99m sestamibiSwissprotsmall molecule
DB09213 DexibuprofenDrugbanksmall molecule
DB13783 AcemetacinDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule
DB14962 Trastuzumab deruxtecanDrugbankbiotech
DB15719 Belantamab mafodotinDrugbankbiotech