Entity Details

Primary name K22E_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35908
EntryNameK22E_HUMAN
FullNameKeratin, type II cytoskeletal 2 epidermal
TaxID9606
Evidenceevidence at protein level
Length639
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesKRT2

GO terms

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GOName
GO:0001533 cornified envelope
GO:0003334 keratinocyte development
GO:0005200 structural constituent of cytoskeleton
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005882 intermediate filament
GO:0008092 cytoskeletal protein binding
GO:0008544 epidermis development
GO:0016020 membrane
GO:0018149 peptide cross-linking
GO:0030280 structural constituent of skin epidermis
GO:0031424 keratinization
GO:0032980 keratinocyte activation
GO:0043616 keratinocyte proliferation
GO:0045095 keratin filament
GO:0045109 intermediate filament organization
GO:0045684 positive regulation of epidermis development
GO:0051546 keratinocyte migration
GO:0070062 extracellular exosome
GO:0070268 cornification

Subcellular Location

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Domains

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DomainNameCategoryType
IPR003054 Keratin, type IIFamilyFamily
IPR018039 Intermediate filament protein, conserved siteSiteConserved site
IPR032444 Keratin type II headDomainDomain
IPR039008 Intermediate filament, rod domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB11157 AnthralinDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule