Entity Details

Primary name WNT5A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP41221
EntryNameWNT5A_HUMAN
FullNameProtein Wnt-5a
TaxID9606
Evidenceevidence at protein level
Length380
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesWNT5A

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001736 establishment of planar polarity
GO:0001756 somitogenesis
GO:0001822 kidney development
GO:0001837 epithelial to mesenchymal transition
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001947 heart looping
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002088 lens development in camera-type eye
GO:0002720 positive regulation of cytokine production involved in immune response
GO:0003138 primary heart field specification
GO:0003139 secondary heart field specification
GO:0003283 atrial septum development
GO:0003323 type B pancreatic cell development
GO:0003402 planar cell polarity pathway involved in axis elongation
GO:0003408 optic cup formation involved in camera-type eye development
GO:0005109 frizzled binding
GO:0005115 receptor tyrosine kinase-like orphan receptor binding
GO:0005125 cytokine activity
GO:0005543 phospholipid binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0007257 obsolete activation of JUN kinase activity
GO:0007411 axon guidance
GO:0007442 hindgut morphogenesis
GO:0007494 midgut development
GO:0008584 male gonad development
GO:0008595 anterior/posterior axis specification, embryo
GO:0009986 cell surface
GO:0010033 response to organic substance
GO:0010595 positive regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010820 positive regulation of T cell chemotaxis
GO:0010976 positive regulation of neuron projection development
GO:0016055 Wnt signaling pathway
GO:0019904 protein domain specific binding
GO:0021891 olfactory bulb interneuron development
GO:0030182 neuron differentiation
GO:0030216 keratinocyte differentiation
GO:0030324 lung development
GO:0030514 negative regulation of BMP signaling pathway
GO:0030666 endocytic vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031012 extracellular matrix
GO:0031343 positive regulation of cell killing
GO:0032092 positive regulation of protein binding
GO:0032148 activation of protein kinase B activity
GO:0032722 positive regulation of chemokine production
GO:0032729 positive regulation of interferon-gamma production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034613 cellular protein localization
GO:0035567 non-canonical Wnt signaling pathway
GO:0036342 post-anal tail morphogenesis
GO:0036517 chemoattraction of serotonergic neuron axon
GO:0036518 chemorepulsion of dopaminergic neuron axon
GO:0038031 non-canonical Wnt signaling pathway via JNK cascade
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042060 wound healing
GO:0042733 embryonic digit morphogenesis
GO:0043032 positive regulation of macrophage activation
GO:0043066 negative regulation of apoptotic process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045165 cell fate commitment
GO:0045198 establishment of epithelial cell apical/basal polarity
GO:0045599 negative regulation of fat cell differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045766 positive regulation of angiogenesis
GO:0045778 positive regulation of ossification
GO:0045807 positive regulation of endocytosis
GO:0045836 positive regulation of meiotic nuclear division
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0048018 receptor ligand activity
GO:0048022 negative regulation of melanin biosynthetic process
GO:0048146 positive regulation of fibroblast proliferation
GO:0048341 paraxial mesoderm formation
GO:0048570 notochord morphogenesis
GO:0048706 embryonic skeletal system development
GO:0048806 genitalia development
GO:0048843 negative regulation of axon extension involved in axon guidance
GO:0048850 hypophysis morphogenesis
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050727 regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0050807 regulation of synapse organization
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051216 cartilage development
GO:0051885 positive regulation of timing of anagen
GO:0051964 negative regulation of synapse assembly
GO:0060028 convergent extension involved in axis elongation
GO:0060029 convergent extension involved in organogenesis
GO:0060065 uterus development
GO:0060067 cervix development
GO:0060068 vagina development
GO:0060070 canonical Wnt signaling pathway
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060157 urinary bladder development
GO:0060324 face development
GO:0060340 positive regulation of type I interferon-mediated signaling pathway
GO:0060599 lateral sprouting involved in mammary gland duct morphogenesis
GO:0060638 mesenchymal-epithelial cell signaling
GO:0060686 negative regulation of prostatic bud formation
GO:0060744 mammary gland branching involved in thelarche
GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation
GO:0060760 positive regulation of response to cytokine stimulus
GO:0060762 regulation of branching involved in mammary gland duct morphogenesis
GO:0060775 planar cell polarity pathway involved in gastrula mediolateral intercalation
GO:0060809 mesodermal to mesenchymal transition involved in gastrulation
GO:0060907 positive regulation of macrophage cytokine production
GO:0061024 membrane organization
GO:0061036 positive regulation of cartilage development
GO:0061347 planar cell polarity pathway involved in outflow tract morphogenesis
GO:0061348 planar cell polarity pathway involved in ventricular septum morphogenesis
GO:0061349 planar cell polarity pathway involved in cardiac right atrium morphogenesis
GO:0061350 planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
GO:0061354 planar cell polarity pathway involved in pericardium morphogenesis
GO:0062009 secondary palate development
GO:0070062 extracellular exosome
GO:0070245 positive regulation of thymocyte apoptotic process
GO:0071222 cellular response to lipopolysaccharide
GO:0071277 cellular response to calcium ion
GO:0071300 cellular response to retinoic acid
GO:0071346 cellular response to interferon-gamma
GO:0071425 hematopoietic stem cell proliferation
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0072201 negative regulation of mesenchymal cell proliferation
GO:0090009 primitive streak formation
GO:0090037 positive regulation of protein kinase C signaling
GO:0090082 positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090103 cochlea morphogenesis
GO:0090179 planar cell polarity pathway involved in neural tube closure
GO:0090630 activation of GTPase activity
GO:0097325 melanocyte proliferation
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:0099054 presynapse assembly
GO:0099068 postsynapse assembly
GO:0099175 regulation of postsynapse organization
GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration
GO:0150012 positive regulation of neuron projection arborization
GO:1900020 positive regulation of protein kinase C activity
GO:1901216 positive regulation of neuron death
GO:1902379 chemoattractant activity involved in axon guidance
GO:1902474 positive regulation of protein localization to synapse
GO:1903827 regulation of cellular protein localization
GO:1904861 excitatory synapse assembly
GO:1904862 inhibitory synapse assembly
GO:1904934 negative regulation of cell proliferation in midbrain
GO:1904938 planar cell polarity pathway involved in axon guidance
GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
GO:1904955 planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation
GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin
GO:2000052 positive regulation of non-canonical Wnt signaling pathway

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR005817 WntFamilyFamily
IPR018161 Wnt protein, conserved siteSiteConserved site
IPR026538 Wnt-5a proteinFamilyFamily
IPR043158 Wnt, C-terminal domainFamilyHomologous superfamily

Diseases

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