Entity Details

Primary name CSK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP41240
EntryNameCSK_HUMAN
FullNameTyrosine-protein kinase CSK
TaxID9606
Evidenceevidence at protein level
Length450
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesCSK

GO terms

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GOName
GO:0002250 adaptive immune response
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0006468 protein phosphorylation
GO:0007420 brain development
GO:0008022 protein C-terminus binding
GO:0008285 negative regulation of cell population proliferation
GO:0010989 negative regulation of low-density lipoprotein particle clearance
GO:0019221 cytokine-mediated signaling pathway
GO:0019903 protein phosphatase binding
GO:0031295 T cell costimulation
GO:0032715 negative regulation of interleukin-6 production
GO:0033673 negative regulation of kinase activity
GO:0034236 protein kinase A catalytic subunit binding
GO:0034332 adherens junction organization
GO:0042802 identical protein binding
GO:0042997 negative regulation of Golgi to plasma membrane protein transport
GO:0043406 positive regulation of MAP kinase activity
GO:0045121 membrane raft
GO:0045779 negative regulation of bone resorption
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0048709 oligodendrocyte differentiation
GO:0050765 negative regulation of phagocytosis
GO:0050852 T cell receptor signaling pathway
GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway
GO:0070062 extracellular exosome
GO:0070064 proline-rich region binding
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0071375 cellular response to peptide hormone stimulus

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035027 CSK-like, SH2 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01254 DasatinibDrugbanksmall molecule
DB02010 StaurosporineDrugbanksmall molecule
DB05075 TG-100801Drugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

79 interactions

InteractorPartnerSourcesPublicationsLink
CSK_HUMANIGF1R_HUMANBioGRID, HPRD, MINT10026153 details
CSK_HUMANCXA1_HUMANHPRD, MINT11035005 details
CSK_HUMANEGFR_HUMANBioGRID, IntAct, MINT16729043 24658140 24797263 25402006 31980649 details
CSK_HUMANSRCN1_HUMANBioGRID, MINT17525734 23383002 details
CSK_HUMANSRC_HUMANBioGRID, HPRD, MINT12387813 17525734 21746865 7513429 7678701 9208935 details
CSK_HUMANID3_HUMANBioGRID, IntAct18255255 details
CSK_HUMANFHL2_HUMANBioGRID, IntAct18255255 details
CSK_HUMANZN212_HUMANBioGRID, IntAct18255255 details
CSK_HUMANPTPRC_HUMANIntAct, MINT19167335 7507203 details
CSK_HUMANPTPRK_HUMANIntAct19167335 details
CSK_HUMANPTPRG_HUMANIntAct19167335 details
CSK_HUMANPTPRZ_HUMANIntAct19167335 details
CSK_HUMANPTPRB_HUMANIntAct19167335 details
CSK_HUMANPTPRJ_HUMANIntAct19167335 details
CSK_HUMANPTPRO_HUMANIntAct19167335 details
CSK_HUMANSCRB1_HUMANMINT14570588 details
CSK_HUMANCSK_HUMANBioGRID, HPRD, MINT14625311 19888460 31980649 9148770 details
CSK_HUMANSHC1_HUMANBioGRID, HPRD, IntAct10037694 12048194 19380743 details
CSK_HUMANPHAG1_HUMANBioGRID, HPRD, IntAct, MINT10790433 12665526 18070987 21746865 28514442 31125786 details
CSK_HUMANLAIR1_HUMANHPRD, MINT16380958 details
CSK_HUMANCAV1_HUMANBioGRID, HPRD, MINT11805080 16678999 24632723 details
CSK_HUMANERBB2_HUMANMINT9461599 details
CSK_HUMANPDPK1_HUMANBioGRID, IntAct25814554 details
CSK_HUMANDDT4L_HUMANIntAct32296183 details
CSK_HUMANKANK4_HUMANBioGRID, IntAct32296183 details
CSK_HUMANPRAG1_HUMANBioGRID, IntAct27116701 31980649 details
CSK_HUMANINSR_HUMANBioGRID, HPRD10026153 details
CSK_HUMANTGFI1_HUMANBioGRID9858471 details
CSK_HUMANDAG1_HUMANBioGRID11724572 details
CSK_HUMANHNRPK_HUMANBioGRID, HPRD12052863 details
CSK_HUMANPECA1_HUMANBioGRID, HPRD9624175 details
CSK_HUMANSDC3_HUMANBioGRID, HPRD9553134 details
CSK_HUMANDAB2_HUMANBioGRID, HPRD12473651 details
CSK_HUMANRASA1_HUMANBioGRID, HPRD7544435 details
CSK_HUMANJUN_HUMANBioGRID16740711 19818398 details
CSK_HUMANKHDR1_HUMANBioGRID7512694 details
CSK_HUMANRGS16_HUMANBioGRID, HPRD11602604 12588871 details
CSK_HUMANZAP70_HUMANBioGRID8621646 details
CSK_HUMANCD3E_HUMANBioGRID8621646 details
CSK_HUMANCD3Z_HUMANBioGRID, HPRD8621646 9172452 details
CSK_HUMANPTN12_HUMANBioGRID, HPRD11158295 27880917 28675297 details
CSK_HUMANCDC45_HUMANBioGRID14625311 details
CSK_HUMANDOK2_HUMANBioGRID15831486 details
CSK_HUMANUBC9_HUMANBioGRID31125786 details
CSK_HUMANPTN18_HUMANHPRD11158295 details
CSK_HUMANDOK3_HUMANHPRD10733577 14993273 details
CSK_HUMANG3BP1_HUMANBioGRID, HPRD, MINT15743820 details
CSK_HUMANERBB3_HUMANBioGRID, MINT16729043 details
CSK_HUMANPARD3_HUMANMINT17053785 details
CSK_HUMANPAXI_HUMANBioGRID, HPRD, IntAct, MINT11695992 14665621 31980649 7529872 details
CSK_HUMANCBL_HUMANBioGRID, IntAct11149930 19380743 details
CSK_HUMANLIRB1_HUMANMINT15474475 details
CSK_HUMANFYN_HUMANBioGRID, HPRD, MINT1985196 7524477 8262983 details
CSK_HUMANSCIMP_HUMANUniProt21930792 details
CSK_HUMANLCK_HUMANBioGRID, HPRD, IntAct12485116 15144186 31980649 details
CSK_HUMANARRB1_HUMANBioGRID, HPRD10753943 19262695 details
CSK_HUMANFAK1_HUMANBioGRID7529872 details
CSK_HUMANAKT1_HUMANBioGRID19262695 26344197 details
CSK_HUMANARRB2_HUMANBioGRID19262695 details
CSK_HUMANTNR6B_HUMANBioGRID24778252 details
CSK_HUMANPTN22_HUMANBioGRID, HPRD27432908 27880917 9582365 details
CSK_HUMANACK1_HUMANBioGRID28739485 details
CSK_HUMANPIAS1_HUMANBioGRID31125786 details
CSK_HUMANPIAS3_HUMANBioGRID31125786 details
CSK_HUMANPIAS4_HUMANBioGRID31125786 details
CSK_HUMANADRB2_HUMANHPRD11278940 details
CSK_HUMANDOK1_HUMANHPRD9221755 details
CSK_HUMANGELS_HUMANHPRD10210201 details
CSK_HUMANHCK_HUMANHPRD11976726 details
CSK_HUMANFGR_HUMANHPRD7515063 8612628 details
CSK_HUMANLYN_HUMANHPRD8612628 details
CSK_HUMANCBP_HUMANHPRD10801129 details
CSK_HUMANCADH5_HUMANHPRD15861137 details
CSK_HUMANKAPCA_HUMANHPRD11181701 details
CSK_HUMANPLD2_HUMANHPRD12697812 details
CSK_HUMANSIT1_HUMANHPRD11433379 details
CSK_HUMANMK15_HUMANHPRD11875070 details
CSK_HUMANTLR3_HUMANHPRD16858407 details
CSK_HUMANCD44_HUMANHPRD11084024 details