Entity Details

Primary name 5HT2B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP41595
EntryName5HT2B_HUMAN
FullName5-hydroxytryptamine receptor 2B
TaxID9606
Evidenceevidence at protein level
Length481
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesHTR2B

GO terms

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GOName
GO:0001587 Gq/11-coupled serotonin receptor activity
GO:0001755 neural crest cell migration
GO:0001819 positive regulation of cytokine production
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001965 G-protein alpha-subunit binding
GO:0002031 G protein-coupled receptor internalization
GO:0003007 heart morphogenesis
GO:0003300 cardiac muscle hypertrophy
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005096 GTPase activator activity
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006874 cellular calcium ion homeostasis
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway
GO:0007208 phospholipase C-activating serotonin receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007610 behavior
GO:0008284 positive regulation of cell population proliferation
GO:0010507 negative regulation of autophagy
GO:0010513 positive regulation of phosphatidylinositol biosynthetic process
GO:0014033 neural crest cell differentiation
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014827 intestine smooth muscle contraction
GO:0016310 phosphorylation
GO:0019722 calcium-mediated signaling
GO:0019934 cGMP-mediated signaling
GO:0030425 dendrite
GO:0030594 neurotransmitter receptor activity
GO:0042310 vasoconstriction
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043406 positive regulation of MAP kinase activity
GO:0045202 synapse
GO:0048598 embryonic morphogenesis
GO:0050795 regulation of behavior
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051378 serotonin binding
GO:0051781 positive regulation of cell division
GO:0060548 negative regulation of cell death
GO:0070371 ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070528 protein kinase C signaling
GO:0071502 cellular response to temperature stimulus
GO:0098664 G protein-coupled serotonin receptor signaling pathway
GO:0098666 G protein-coupled serotonin receptor complex

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000482 5-Hydroxytryptamine 2B receptorFamilyFamily
IPR002231 5-hydroxytryptamine receptor familyFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00247 MethysergideDrugbanksmall molecule
DB00248 CabergolineDrugbanksmall molecule
DB00315 ZolmitriptanDrugbanksmall molecule
DB00320 DihydroergotamineDrugbanksmall molecule
DB00353 MethylergometrineDrugbanksmall molecule
DB00477 ChlorpromazineDrugbanksmall molecule
DB00508 TriflupromazineDrugbanksmall molecule
DB00543 AmoxapineDrugbanksmall molecule
DB00574 FenfluramineDrugbanksmall molecule
DB00589 LisurideDrugbanksmall molecule
DB00696 ErgotamineDrugbanksmall molecule
DB00714 ApomorphineDrugbanksmall molecule
DB00715 ParoxetineDrugbanksmall molecule
DB00805 MinaprineDrugbanksmall molecule
DB00924 CyclobenzaprineDrugbanksmall molecule
DB01049 Ergoloid mesylateDrugbanksmall molecule
DB01079 TegaserodDrugbanksmall molecule
DB01142 DoxepinDrugbanksmall molecule
DB01186 PergolideDrugbanksmall molecule
DB01200 BromocriptineDrugbanksmall molecule
DB01221 KetamineDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01239 ChlorprothixeneDrugbanksmall molecule
DB01242 ClomipramineDrugbanksmall molecule
DB01392 YohimbineDrugbanksmall molecule
DB01454 MidomafetamineDrugbanksmall molecule
DB04829 Lysergic acid diethylamideDrugbanksmall molecule
DB05461 OPC-28326Drugbanksmall molecule
DB05492 Epicept NP-1Drugbanksmall molecule
DB05607 PRX-08066Drugbanksmall molecule
DB06016 CariprazineDrugbanksmall molecule
DB06148 MianserinDrugbanksmall molecule
DB06153 PizotifenDrugbanksmall molecule
DB06216 AsenapineDrugbanksmall molecule
DB06229 OcaperidoneDrugbanksmall molecule
DB06678 EsmirtazapineDrugbanksmall molecule
DB09286 PipamperoneDrugbanksmall molecule
DB09304 SetiptilineDrugbanksmall molecule
DB11273 DihydroergocornineDrugbanksmall molecule
DB12141 GilteritinibDrugbanksmall molecule
DB13025 TiaprideDrugbanksmall molecule
DB13345 DihydroergocristineDrugbanksmall molecule

Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
5HT2B_HUMANMPDZ_HUMANMINT11150294 details
5HT2B_HUMANG6PC3_HUMANBioGRID, MINT28298427 details
5HT2B_HUMANCHPT1_HUMANBioGRID, MINT28298427 details
5HT2B_HUMANCBR1_HUMANBioGRID, MINT28298427 details
5HT2B_HUMANBNI3L_HUMANBioGRID, MINT28298427 details
5HT2B_HUMANBNIP3_HUMANBioGRID, MINT28298427 details
5HT2B_HUMANAT1B1_HUMANBioGRID, MINT28298427 details
5HT2B_HUMANABCA3_HUMANBioGRID, MINT28298427 details
5HT2B_HUMANHDGR2_HUMANBioGRID, MINT28298427 details
5HT2B_HUMANOAZ1_HUMANBioGRID, MINT28298427 details
5HT2B_HUMANHAT1_HUMANBioGRID, MINT28298427 details
5HT2B_HUMANPLLP_HUMANBioGRID, MINT28298427 details
5HT2B_HUMANNIPA2_HUMANBioGRID, MINT28298427 details
5HT2B_HUMANPPR3F_HUMANBioGRID, MINT28298427 details
5HT2B_HUMANMETRN_HUMANBioGRID, MINT28298427 details
5HT2B_HUMANMATR3_HUMANBioGRID, MINT28298427 details
5HT2B_HUMANKIF19_HUMANBioGRID, MINT28298427 details
5HT2B_HUMANINSI1_HUMANBioGRID, MINT28298427 details
5HT2B_HUMANNAT14_HUMANBioGRID, MINT28298427 details
5HT2B_HUMANRAE1L_HUMANBioGRID, MINT28298427 details
5HT2B_HUMANTR1L1_HUMANBioGRID, MINT28298427 details
5HT2B_HUMANCTL2_HUMANBioGRID, MINT28298427 details
5HT2B_HUMANG6PT2_HUMANBioGRID, MINT28298427 details
5HT2B_HUMANCOPT2_HUMANBioGRID, MINT28298427 details
5HT2B_HUMAN5HT2A_HUMANIntAct28258217 details
5HT2B_HUMAN5HT2C_HUMANIntAct28258217 details
5HT2B_HUMANLNX1_HUMANBioGRID22889411 details
5HT2B_HUMANSNTA1_HUMANBioGRID15123239 details
5HT2B_HUMANWRIP1_HUMANIntAct26617989 details
5HT2B_HUMANAGTR1_HUMANBioGRID19023134 details
5HT2B_HUMANGNAQ_HUMANHPRD11916537 details
5HT2B_HUMANGNA11_HUMANHPRD11916537 8621713 details