Entity Details

Primary name CATK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP43235
EntryNameCATK_HUMAN
FullNameCathepsin K
TaxID9606
Evidenceevidence at protein level
Length329
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesCTSK

GO terms

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GOName
GO:0000422 autophagy of mitochondrion
GO:0001968 fibronectin binding
GO:0002224 toll-like receptor signaling pathway
GO:0004197 cysteine-type endopeptidase activity
GO:0005518 collagen binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005654 nucleoplasm
GO:0005764 lysosome
GO:0006508 proteolysis
GO:0006590 thyroid hormone generation
GO:0006955 immune response
GO:0008234 cysteine-type peptidase activity
GO:0016324 apical plasma membrane
GO:0022617 extracellular matrix disassembly
GO:0030574 collagen catabolic process
GO:0036021 endolysosome lumen
GO:0043202 lysosomal lumen
GO:0043231 intracellular membrane-bounded organelle
GO:0043394 proteoglycan binding
GO:0045616 regulation of keratinocyte differentiation
GO:0051603 proteolysis involved in cellular protein catabolic process

Subcellular Location

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Subcellular Location
Apical cell membrane
Lysosome
Secreted

Domains

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DomainNameCategoryType
IPR000169 Cysteine peptidase, cysteine active siteSiteActive site
IPR000668 Peptidase C1A, papain C-terminalDomainDomain
IPR013201 Cathepsin propeptide inhibitor domain (I29)DomainDomain
IPR015644 Peptidase C1A, cathepsin KFamilyFamily
IPR025660 Cysteine peptidase, histidine active siteSiteActive site
IPR025661 Cysteine peptidase, asparagine active siteSiteActive site
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily
IPR039417 Papain-like cysteine endopeptidaseDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB01858 [1-(4-Fluorobenzyl)Cyclobutyl]Methyl (1s)-1-[Oxo(1h-Pyrazol-5-Ylamino)Acetyl]PentylcarbamateDrugbanksmall molecule
DB02679 CyanamideDrugbanksmall molecule
DB02869 3-amino-5-phenylpentaneDrugbanksmall molecule
DB03405 N2-[(Benzyloxy)carbonyl]-N-[(3R)-1-{N-[(benzyloxy)carbonyl]-L-leucyl}-4-oxo-3-pyrrolidinyl]-L-leucinamideDrugbanksmall molecule
DB03456 N2-[(benzyloxy)carbonyl]-n1-[(3S)-1-cyanopyrrolidin-3-yl]-l-leucinamideDrugbanksmall molecule
DB03642 N-[(2S)-4-Methyl-1-oxo-1-{[(4S)-3-oxo-1-(2-pyridinylsulfonyl)-4-azepanyl]amino}-2-pentanyl]-1-benzofuran-2-carboxamideDrugbanksmall molecule
DB03891 Dibenzyl (carbonylbis{2,1-hydrazinediyl[(2S)-4-methyl-1-oxo-1,2-pentanediyl]})biscarbamateDrugbanksmall molecule
DB04234 N2-({[(4-Bromophenyl)Methyl]Oxy}Carbonyl)-N1-[(1s)-1-Formylpentyl]-L-LeucinamideDrugbanksmall molecule
DB04244 (2R)-2-(3-Biphenylyl)-N-{(2R)-2-hydroxy-3-[(2-pyridinylsulfonyl)amino]propyl}-4-methylpentanamideDrugbanksmall molecule
DB04523 Tert-Butyl(1s)-1-Cyclohexyl-2-OxoethylcarbamateDrugbanksmall molecule
DB05736 MIV-701Drugbanksmall molecule
DB06367 RelacatibDrugbanksmall molecule
DB06670 OdanacatibDrugbanksmall molecule
DB07563 1-{7-cyclohexyl-6-[4-(4-methylpiperazin-1-yl)benzyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}methanamineDrugbanksmall molecule
DB07592 (2R)-3-Methyl-1-phenyl-2-butanyl [(2S)-1-oxo-2-hexanyl]carbamateDrugbanksmall molecule
DB07593 1-(PHENYLMETHYL)CYCLOPENTYL[(1S)-1-FORMYLPENTYL]CARBAMATEDrugbanksmall molecule
DB07965 6-(cyclohexylamino)-9-[2-(4-methylpiperazin-1-yl)-ethyl]-9H-purine-2-carbonitrileDrugbanksmall molecule
DB07967 9-CYCLOPENTYL-6-[2-(3-IMIDAZOL-1-YL-PROPOXY)-PHENYLAMINO]-9H-PURINE-2-CARBONITRILEDrugbanksmall molecule
DB08270 N-(2-AMINOETHYL)-N~2~-{(1S)-1-[4'-(AMINOSULFONYL)BIPHENYL-4-YL]-2,2,2-TRIFLUOROETHYL}-L-LEUCINAMIDEDrugbanksmall molecule
DB08287 (1R,2R)-N-(2-Aminoethyl)-2-{[(4-methoxyphenyl)sulfonyl]methyl}cyclohexanecarboxamideDrugbanksmall molecule
DB08594 TERT-BUTYL 2-CYANO-2-METHYLHYDRAZINECARBOXYLATEDrugbanksmall molecule
DB15599 MIV-711Drugbanksmall molecule