Entity Details

Primary name NOTC1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP46531
EntryNameNOTC1_HUMAN
FullNameNeurogenic locus notch homolog protein 1
TaxID9606
Evidenceevidence at protein level
Length2555
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesNOTCH1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000139 Golgi membrane
GO:0001669 acrosomal vesicle
GO:0001701 in utero embryonic development
GO:0001708 cell fate specification
GO:0001837 epithelial to mesenchymal transition
GO:0001889 liver development
GO:0001947 heart looping
GO:0002040 sprouting angiogenesis
GO:0002052 positive regulation of neuroblast proliferation
GO:0002193 MAML1-RBP-Jkappa- ICN1 complex
GO:0002437 inflammatory response to antigenic stimulus
GO:0003151 outflow tract morphogenesis
GO:0003157 endocardium development
GO:0003160 endocardium morphogenesis
GO:0003162 atrioventricular node development
GO:0003169 coronary vein morphogenesis
GO:0003180 aortic valve morphogenesis
GO:0003181 atrioventricular valve morphogenesis
GO:0003182 coronary sinus valve morphogenesis
GO:0003184 pulmonary valve morphogenesis
GO:0003192 mitral valve formation
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003203 endocardial cushion morphogenesis
GO:0003207 cardiac chamber formation
GO:0003208 cardiac ventricle morphogenesis
GO:0003209 cardiac atrium morphogenesis
GO:0003213 cardiac right atrium morphogenesis
GO:0003214 cardiac left ventricle morphogenesis
GO:0003219 cardiac right ventricle formation
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0003241 growth involved in heart morphogenesis
GO:0003252 negative regulation of cell proliferation involved in heart valve morphogenesis
GO:0003256 regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0003270 Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
GO:0003273 cell migration involved in endocardial cushion formation
GO:0003332 negative regulation of extracellular matrix constituent secretion
GO:0003344 pericardium morphogenesis
GO:0003713 transcription coactivator activity
GO:0004857 enzyme inhibitor activity
GO:0004888 transmembrane signaling receptor activity
GO:0005112 Notch binding
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006955 immune response
GO:0006959 humoral immune response
GO:0007219 Notch signaling pathway
GO:0007221 positive regulation of transcription of Notch receptor target
GO:0007283 spermatogenesis
GO:0007368 determination of left/right symmetry
GO:0007386 compartment pattern specification
GO:0007411 axon guidance
GO:0007440 foregut morphogenesis
GO:0007492 endoderm development
GO:0007507 heart development
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0009912 auditory receptor cell fate commitment
GO:0009986 cell surface
GO:0010614 negative regulation of cardiac muscle hypertrophy
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010812 negative regulation of cell-substrate adhesion
GO:0010832 negative regulation of myotube differentiation
GO:0014031 mesenchymal cell development
GO:0014807 regulation of somitogenesis
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0019899 enzyme binding
GO:0021515 cell differentiation in spinal cord
GO:0021915 neural tube development
GO:0030216 keratinocyte differentiation
GO:0030279 negative regulation of ossification
GO:0030324 lung development
GO:0030335 positive regulation of cell migration
GO:0030513 positive regulation of BMP signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0030900 forebrain development
GO:0031069 hair follicle morphogenesis
GO:0031100 animal organ regeneration
GO:0031490 chromatin DNA binding
GO:0031960 response to corticosteroid
GO:0032495 response to muramyl dipeptide
GO:0032496 response to lipopolysaccharide
GO:0035116 embryonic hindlimb morphogenesis
GO:0035148 tube formation
GO:0035914 skeletal muscle cell differentiation
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0042246 tissue regeneration
GO:0042802 identical protein binding
GO:0043086 negative regulation of catalytic activity
GO:0043235 receptor complex
GO:0045070 positive regulation of viral genome replication
GO:0045603 positive regulation of endothelial cell differentiation
GO:0045608 negative regulation of inner ear auditory receptor cell differentiation
GO:0045618 positive regulation of keratinocyte differentiation
GO:0045662 negative regulation of myoblast differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045955 negative regulation of calcium ion-dependent exocytosis
GO:0045967 negative regulation of growth rate
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
GO:0046533 negative regulation of photoreceptor cell differentiation
GO:0046579 positive regulation of Ras protein signal transduction
GO:0048103 somatic stem cell division
GO:0048708 astrocyte differentiation
GO:0048709 oligodendrocyte differentiation
GO:0048711 positive regulation of astrocyte differentiation
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048873 homeostasis of number of cells within a tissue
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050768 negative regulation of neurogenesis
GO:0055008 cardiac muscle tissue morphogenesis
GO:0060038 cardiac muscle cell proliferation
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060253 negative regulation of glial cell proliferation
GO:0060271 cilium assembly
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060354 negative regulation of cell adhesion molecule production
GO:0060411 cardiac septum morphogenesis
GO:0060412 ventricular septum morphogenesis
GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0060740 prostate gland epithelium morphogenesis
GO:0060768 regulation of epithelial cell proliferation involved in prostate gland development
GO:0060842 arterial endothelial cell differentiation
GO:0060843 venous endothelial cell differentiation
GO:0060948 cardiac vascular smooth muscle cell development
GO:0060956 endocardial cell differentiation
GO:0060979 vasculogenesis involved in coronary vascular morphogenesis
GO:0060982 coronary artery morphogenesis
GO:0061314 Notch signaling involved in heart development
GO:0061384 heart trabecula morphogenesis
GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0062043 positive regulation of cardiac epithelial to mesenchymal transition
GO:0070168 negative regulation of biomineral tissue development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070986 left/right axis specification
GO:0071372 cellular response to follicle-stimulating hormone stimulus
GO:0072017 distal tubule development
GO:0072044 collecting duct development
GO:0072144 glomerular mesangial cell development
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097150 neuronal stem cell population maintenance
GO:0120163 negative regulation of cold-induced thermogenesis
GO:1901201 regulation of extracellular matrix assembly
GO:1902263 apoptotic process involved in embryonic digit morphogenesis
GO:1902339 positive regulation of apoptotic process involved in morphogenesis
GO:1903849 positive regulation of aorta morphogenesis
GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin
GO:2000737 negative regulation of stem cell differentiation
GO:2000811 negative regulation of anoikis
GO:2000974 negative regulation of pro-B cell differentiation
GO:2001027 negative regulation of endothelial cell chemotaxis

Subcellular Location

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Subcellular Location
Cell membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR000800 Notch domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR002110 Ankyrin repeatRepeatRepeat
IPR008297 NotchFamilyFamily
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR010660 Notch, NOD domainDomainDomain
IPR011656 Notch, NODP domainDomainDomain
IPR013032 EGF-like, conserved siteSiteConserved site
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR022362 Neurogenic locus Notch 1FamilyFamily
IPR024600 Domain of unknown function DUF3454, notchDomainDomain
IPR035993 Notch-like domain superfamilyFamilyHomologous superfamily
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

123 interactions

InteractorPartnerSourcesPublicationsLink
NOTC1_HUMANSNW1_HUMANBioGRID, HPRD, IntAct10713164 11404076 15546612 17573339 details
NOTC1_HUMANSUH_HUMANBioGRID, DIP, HPRD, IntAct, MINT10637481 10713164 11390662 11997524 12644465 16530044 17284587 17526737 17573339 17636029 19321451 19800882 19907488 21475249 21820430 22100894 22143792 22325781 23022380 23103515 25609649 26033182 26186194 26496610 28514442 30967258 30975888 8749394 9111040 details
NOTC1_HUMANXRCC6_HUMANBioGRID, HPRD, IntAct16169070 details
NOTC1_HUMANMAML1_HUMANBioGRID, DIP, HPRD, IntAct, MINT11101851 11390662 11997524 12370315 12644465 16530044 17573339 18427106 19907488 20972443 21820430 22100894 22325781 23022380 30975888 details
NOTC1_HUMANGFI1B_HUMANBioGRID, HPRD, IntAct16713569 details
NOTC1_HUMANNFKB1_HUMANBioGRID, HPRD, MINT11418662 16319921 8642313 details
NOTC1_HUMANXIAP_HUMANBioGRID, HPRD, MINT17318174 details
NOTC1_HUMANCAC1A_HUMANBioGRID, IntAct21078624 details
NOTC1_HUMANPIN1_HUMANIntAct19151708 details
NOTC1_HUMANJAG1_HUMANBioGRID, DIP, HPRD, InnateDB11006133 18660822 20720151 21820430 23086448 details
NOTC1_HUMANHIF1N_HUMANIntAct26752685 details
NOTC1_HUMANFBXW7_HUMANBioGRID, DIP, HPRD, MINT11425854 11585921 17526737 17646408 17646409 17909182 20823234 21820430 22388891 23022380 24085301 25344755 26033182 26108681 27229929 27247421 27806347 28459460 30510140 31152129 31285543 32041737 32792479 33086033 details
NOTC1_HUMANUBP7_HUMANBioGRID, MINT23022380 30224337 30370059 details
NOTC1_HUMANMAML3_HUMANBioGRID, HPRD, MINT12370315 23022380 details
NOTC1_HUMANATM_HUMANDIP25895060 details
NOTC1_HUMANSMAD3_HUMANBioGRID, HPRD14638857 details
NOTC1_HUMANTYY1_HUMANBioGRID, HPRD12913000 details
NOTC1_HUMANDTX1_HUMANBioGRID, HPRD11226752 11564735 17573339 20208568 29440432 details
NOTC1_HUMANDLL1_HUMANBioGRID, HPRD11006133 details
NOTC1_HUMANJAG2_HUMANBioGRID, HPRD11006133 details
NOTC1_HUMANLEF1_HUMANBioGRID, HPRD11604490 details
NOTC1_HUMANNUMB_HUMANBioGRID, HPRD12682059 23252402 8755477 details
NOTC1_HUMANGSK3B_HUMANBioGRID, HPRD12123574 details
NOTC1_HUMANCCN3_HUMANBioGRID, HPRD12050162 details
NOTC1_HUMANPSN1_HUMANBioGRID, HPRD10077672 10206645 12374741 28351972 details
NOTC1_HUMANMAML2_HUMANBioGRID, HPRD12370315 details
NOTC1_HUMANEP300_HUMANBioGRID, HPRD11604511 19838210 22100894 details
NOTC1_HUMANAKT1_HUMANBioGRID18440314 27229929 details
NOTC1_HUMANCTNB1_HUMANBioGRID19000719 details
NOTC1_HUMANSNAI1_HUMANBioGRID22128911 details
NOTC1_HUMANMDM2_HUMANBioGRID22128911 23252402 details
NOTC1_HUMANRUNX3_HUMANBioGRID19800882 details
NOTC1_HUMANILK_HUMANBioGRID17526737 details
NOTC1_HUMANKCC4_HUMANBioGRID23103515 details
NOTC1_HUMANEGFL7_HUMANBioGRID19503073 details
NOTC1_HUMANWWP1_HUMANBioGRID16785210 details
NOTC1_HUMANUBP12_HUMANBioGRID22778262 details
NOTC1_HUMANKPCD_HUMANBioGRID24662486 details
NOTC1_HUMANZMIZ1_HUMANBioGRID26522984 details
NOTC1_HUMANM3K1_HUMANBioGRID27806347 details
NOTC1_HUMANMAGA1_HUMANBioGRID28459460 details
NOTC1_HUMANPRAF3_HUMANBioGRID27229929 details
NOTC1_HUMANB3GT4_HUMANBioGRID27229929 details
NOTC1_HUMANCE57L_HUMANBioGRID27229929 details
NOTC1_HUMANCO4A6_HUMANBioGRID27229929 details
NOTC1_HUMANEXT1_HUMANBioGRID27229929 details
NOTC1_HUMANF185A_HUMANBioGRID27229929 details
NOTC1_HUMANP33MX_HUMANBioGRID27229929 details
NOTC1_HUMANLNX2_HUMANBioGRID27229929 details
NOTC1_HUMANRHOA_HUMANBioGRID27229929 details
NOTC1_HUMANGOGA2_HUMANBioGRID27229929 details
NOTC1_HUMANHMGN5_HUMANBioGRID27229929 details
NOTC1_HUMANMAGD1_HUMANBioGRID27229929 details
NOTC1_HUMANGOPC_HUMANBioGRID27229929 details
NOTC1_HUMANOBF1_HUMANBioGRID27229929 details
NOTC1_HUMANTLE3_HUMANBioGRID27229929 details
NOTC1_HUMANDAZP2_HUMANBioGRID27229929 details
NOTC1_HUMANCASR_HUMANBioGRID17573339 details
NOTC1_HUMANUBP10_HUMANBioGRID30975888 details
NOTC1_HUMANUBP2_HUMANBioGRID30975888 details
NOTC1_HUMANF16P1_HUMANBioGRID32041737 details
NOTC1_HUMANSTC1_HUMANBioGRID29196129 details
NOTC1_HUMANDTX2_HUMANHPRD11226752 details
NOTC1_HUMANNUMBL_HUMANHPRD9169836 details
NOTC1_HUMANREL_HUMANHPRD, MINT16319921 details
NOTC1_HUMANLIRB2_HUMANIntAct25714926 details
NOTC1_HUMANIMB1_HUMANBioGRID, MINT23022380 26893479 details
NOTC1_HUMANHIF1A_HUMANDIP18427106 details
NOTC1_HUMANNOTC1_HUMANBioGRID, HPRD, IntAct10669757 11425854 11585921 16738328 details
NOTC1_HUMANHXA1_HUMANMINT21653829 details
NOTC1_HUMANMBD1_HUMANMINT21653829 details
NOTC1_HUMANLCK_HUMANBioGRID, HPRD14583609 details
NOTC1_HUMANPK3CA_HUMANBioGRID14583609 details
NOTC1_HUMANCNTN1_HUMANBioGRID, HPRD14567914 details
NOTC1_HUMANTF65_HUMANBioGRID, HPRD8642313 details
NOTC1_HUMANCBL_HUMANBioGRID, HPRD11777909 26052821 details
NOTC1_HUMANKAT5_HUMANBioGRID17368826 17636029 details
NOTC1_HUMANA4_HUMANBioGRID16175584 17368826 details
NOTC1_HUMANAPBB1_HUMANBioGRID17368826 details
NOTC1_HUMANEIF3F_HUMANBioGRID21124883 details
NOTC1_HUMANEPN1_HUMANBioGRID20573067 details
NOTC1_HUMANITCH_HUMANBioGRID, HPRD12682059 23886940 details
NOTC1_HUMANNED4L_HUMANBioGRID23886940 details
NOTC1_HUMANARRB1_HUMANBioGRID23886940 31822496 details
NOTC1_HUMANTGFR1_HUMANBioGRID24399296 details
NOTC1_HUMANRND3_HUMANBioGRID26108681 details
NOTC1_HUMANRAB5A_HUMANBioGRID24662486 details
NOTC1_HUMANRAB7A_HUMANBioGRID24662486 details
NOTC1_HUMANLAMP1_HUMANBioGRID24662486 29440432 34079125 details
NOTC1_HUMANHGS_HUMANBioGRID24662486 details
NOTC1_HUMANMLP3A_HUMANBioGRID27806347 30207627 details
NOTC1_HUMANSQSTM_HUMANBioGRID27806347 30207627 details
NOTC1_HUMANHS90B_HUMANBioGRID28143869 details
NOTC1_HUMANCHIP_HUMANBioGRID28143869 details
NOTC1_HUMANFANCA_HUMANBioGRID19321451 details
NOTC1_HUMANFANCC_HUMANBioGRID19321451 details
NOTC1_HUMANFANCF_HUMANBioGRID19321451 details
NOTC1_HUMANFANCG_HUMANBioGRID19321451 details
NOTC1_HUMANBACD3_HUMANBioGRID25401743 details
NOTC1_HUMANCUL3_HUMANBioGRID25401743 details
NOTC1_HUMANDTX4_HUMANBioGRID28611181 details
NOTC1_HUMANADA10_HUMANBioGRID28611181 details
NOTC1_HUMANTRIM3_HUMANBioGRID26893479 details
NOTC1_HUMANRAB4A_HUMANBioGRID29440432 details
NOTC1_HUMANTRBP2_HUMANBioGRID28174252 details
NOTC1_HUMANDAB1_HUMANBioGRID22394407 details
NOTC1_HUMANUBP8_HUMANBioGRID31527799 details
NOTC1_HUMANNEDD4_HUMANBioGRID33262943 details
NOTC1_HUMANRET3_HUMANHPRD11511084 details
NOTC1_HUMANPK3CG_HUMANHPRD14583609 details
NOTC1_HUMANKAT2A_HUMANHPRD10747963 details
NOTC1_HUMANLFNG_HUMANHPRD10935626 12486116 details
NOTC1_HUMANMFNG_HUMANHPRD10935626 12486116 details
NOTC1_HUMANADA17_HUMANHPRD10882063 9620803 details
NOTC1_HUMANDLL4_HUMANHPRD10837024 11739188 details
NOTC1_HUMANKAT2B_HUMANHPRD10747963 details
NOTC1_HUMANWDR12_HUMANHPRD11827460 details
NOTC1_HUMANAPBA1_HUMANHPRD14756819 details
NOTC1_HUMANMEF2C_HUMANHPRD10082551 details
NOTC1_HUMANPSN2_HUMANHPRD11518718 details
NOTC1_HUMANBL1S1_HUMANHPRD10747963 details
NOTC1_HUMANOFUT1_HUMANHPRD12697902 details
NOTC1_HUMANFURIN_HUMANHPRD9653148 details