Entity Details

Primary name XDH_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP47989
EntryNameXDH_HUMAN
FullNameXanthine dehydrogenase/oxidase
TaxID9606
Evidenceevidence at protein level
Length1333
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesXDH

GO terms

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GOName
GO:0001933 negative regulation of protein phosphorylation
GO:0001937 negative regulation of endothelial cell proliferation
GO:0002250 adaptive immune response
GO:0004854 xanthine dehydrogenase activity
GO:0004855 xanthine oxidase activity
GO:0005506 iron ion binding
GO:0005615 extracellular space
GO:0005777 peroxisome
GO:0005829 cytosol
GO:0006148 inosine catabolic process
GO:0006154 adenosine catabolic process
GO:0006195 purine nucleotide catabolic process
GO:0006196 AMP catabolic process
GO:0006204 IMP catabolic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007595 lactation
GO:0009055 electron transfer activity
GO:0009115 xanthine catabolic process
GO:0010629 negative regulation of gene expression
GO:0016226 iron-sulfur cluster assembly
GO:0016491 oxidoreductase activity
GO:0016529 sarcoplasmic reticulum
GO:0042803 protein homodimerization activity
GO:0043546 molybdopterin cofactor binding
GO:0045602 negative regulation of endothelial cell differentiation
GO:0046038 GMP catabolic process
GO:0046055 dGMP catabolic process
GO:0050660 flavin adenine dinucleotide binding
GO:0051537 2 iron, 2 sulfur cluster binding
GO:0051898 negative regulation of protein kinase B signaling
GO:0070674 hypoxanthine dehydrogenase activity
GO:0070675 hypoxanthine oxidase activity
GO:0071949 FAD binding
GO:1900745 positive regulation of p38MAPK cascade
GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2001213 negative regulation of vasculogenesis

Subcellular Location

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Subcellular Location
Cytoplasm
Peroxisome
Secreted

Domains

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DomainNameCategoryType
IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerheadDomainDomain
IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domainDomainDomain
IPR002346 Molybdopterin dehydrogenase, FAD-bindingDomainDomain
IPR002888 [2Fe-2S]-bindingDomainDomain
IPR005107 CO dehydrogenase flavoprotein, C-terminalDomainDomain
IPR006058 2Fe-2S ferredoxin, iron-sulphur binding siteSiteBinding site
IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin bindingDomainDomain
IPR014307 Xanthine dehydrogenase, small subunitDomainDomain
IPR016166 FAD-binding domain, PCMH-typeDomainDomain
IPR016208 Aldehyde oxidase/xanthine dehydrogenaseFamilyFamily
IPR022407 Oxidoreductase, molybdopterin binding siteSiteBinding site
IPR036010 2Fe-2S ferredoxin-like superfamilyFamilyHomologous superfamily
IPR036318 FAD-binding, type PCMH-like superfamilyFamilyHomologous superfamily
IPR036683 CO dehydrogenase flavoprotein, C-terminal domain superfamilyFamilyHomologous superfamily
IPR036856 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamilyFamilyHomologous superfamily
IPR036884 [2Fe-2S]-binding domain superfamilyFamilyHomologous superfamily
IPR037165 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00041 AldesleukinDrugbankbiotech
DB00127 SpermineDrugbanksmall molecule
DB00157 NADHDrugbanksmall molecule
DB00170 MenadioneDrugbanksmall molecule
DB00336 NitrofuralDrugbanksmall molecule
DB00339 PyrazinamideDrugbanksmall molecule
DB00437 AllopurinolDrugbanksmall molecule
DB00515 CisplatinDrugbanksmall molecule
DB00583 LevocarnitineDrugbanksmall molecule
DB00694 DaunorubicinDrugbanksmall molecule
DB00746 DeferoxamineDrugbanksmall molecule
DB00831 TrifluoperazineDrugbanksmall molecule
DB00856 ChlorphenesinSwissprotsmall molecule
DB00958 CarboplatinSwissprotsmall molecule
DB00993 AzathioprineDrugbanksmall molecule
DB00997 DoxorubicinDrugbanksmall molecule
DB01020 Isosorbide mononitrateDrugbanksmall molecule
DB01033 MercaptopurineDrugbanksmall molecule
DB01136 CarvedilolDrugbanksmall molecule
DB01168 ProcarbazineDrugbanksmall molecule
DB01685 TopiroxostatDrugbanksmall molecule
DB03147 Flavin adenine dinucleotideDrugbanksmall molecule
DB03328 Dioxo(sulfanyl)molybdenumDrugbanksmall molecule
DB03516 EniluracilDrugbanksmall molecule
DB03841 NiraxostatDrugbanksmall molecule
DB04335 InosineDrugbanksmall molecule
DB04854 FebuxostatDrugbanksmall molecule
DB05262 OxypurinolDrugbanksmall molecule
DB06478 PorfiromycinSwissprotsmall molecule
DB12466 FavipiravirDrugbanksmall molecule

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
XDH_HUMANGRIP1_HUMANBioGRID, IntAct32296183 details
XDH_HUMANUBP15_HUMANBioGRID31578733 details
XDH_HUMANBT1A1_HUMANHPRD12456835 details