Entity Details

Primary name CASP4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49662
EntryNameCASP4_HUMAN
FullNameCaspase-4
TaxID9606
Evidenceevidence at protein level
Length377
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesCASP4

GO terms

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GOName
GO:0004197 cysteine-type endopeptidase activity
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0016540 protein autoprocessing
GO:0032991 protein-containing complex
GO:0042981 regulation of apoptotic process
GO:0045087 innate immune response
GO:0050700 CARD domain binding
GO:0050727 regulation of inflammatory response
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070269 pyroptosis
GO:0072557 IPAF inflammasome complex
GO:0072559 NLRP3 inflammasome complex
GO:0097169 AIM2 inflammasome complex
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097194 execution phase of apoptosis
GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway
GO:1904646 cellular response to amyloid-beta

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum membrane
Inflammasome
Mitochondrion
Secreted

Domains

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DomainNameCategoryType
IPR001309 Peptidase C14, p20 domainDomainDomain
IPR001315 CARD domainDomainDomain
IPR002138 Peptidase C14, caspase non-catalytic subunit p10DomainDomain
IPR002398 Peptidase C14 familyFamilyFamily
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR015917 Peptidase C14A, caspase catalytic domainDomainDomain
IPR016129 Peptidase family C14A, His active siteSiteActive site
IPR029030 Caspase-like domain superfamilyFamilyHomologous superfamily
IPR033139 Peptidase family C14A, cysteine active siteSiteActive site

Diseases

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Drugs

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DrugNameSourceType
DB06255 Incadronic acidDrugbanksmall molecule

Interactions

38 interactions

InteractorPartnerSourcesPublicationsLink
CASP4_HUMANIL37_HUMANBioGRID12096920 details
CASP4_HUMANSPB9_HUMANBioGRID, HPRD10477277 details
CASP4_HUMANGSDMD_HUMANDIP26375003 details
CASP4_HUMANMYH9_HUMANBioGRID, IntAct21988832 details
CASP4_HUMANCASP8_HUMANBioGRID8962078 details
CASP4_HUMANA4_HUMANBioGRID, HPRD15123740 21832049 details
CASP4_HUMANIL18_HUMANBioGRID, HPRD12096920 15326478 details
CASP4_HUMANCASPA_HUMANBioGRID, HPRD8962078 details
CASP4_HUMANELF4_HUMANBioGRID, IntAct21988832 details
CASP4_HUMANU520_HUMANIntAct17353931 details
CASP4_HUMANHIG1A_HUMANIntAct17353931 details
CASP4_HUMANTRAF6_HUMANBioGRID18056395 details
CASP4_HUMANAPAF_HUMANBioGRID, HPRD9539746 details
CASP4_HUMANDESP_HUMANHPRD15500642 details
CASP4_HUMANCASP4_HUMANHPRD10872455 details
CASP4_HUMANSSRD_HUMANIntAct17353931 details
CASP4_HUMANPSN1_HUMANHPRD10069390 details
CASP4_HUMANTM147_HUMANIntAct17353931 details
CASP4_HUMANNOD1_HUMANBioGRID, HPRD10329646 details
CASP4_HUMANIL1B_HUMANHPRD1919001 7797510 details
CASP4_HUMANUBXN1_HUMANIntAct17353931 details
CASP4_HUMANLSM10_HUMANIntAct17353931 details
CASP4_HUMANMDN1_HUMANIntAct17353931 details
CASP4_HUMANCASP3_HUMANHPRD9233763 9694885 details
CASP4_HUMANHACD3_HUMANIntAct17353931 details
CASP4_HUMANCASPE_HUMANBioGRID, HPRD9792675 details
CASP4_HUMANUMPS_HUMANIntAct17353931 details
CASP4_HUMANRU2A_HUMANIntAct17353931 details
CASP4_HUMANSMC4_HUMANIntAct17353931 details
CASP4_HUMANNOD2_HUMANDIP18511561 details
CASP4_HUMANDCTN1_HUMANIntAct17353931 details
CASP4_HUMANTAP26_HUMANIntAct17353931 details
CASP4_HUMANXLRS1_HUMANBioGRID19765263 details
CASP4_HUMANPSMD6_HUMANIntAct17353931 details
CASP4_HUMANCOPE_HUMANIntAct17353931 details
CASP4_HUMANTXTP_HUMANIntAct17353931 details
CASP4_HUMANXIAP_HUMANBioGRID11927604 details
CASP4_HUMANPA24A_HUMANHPRD9875225 details