Entity Details

Primary name TPMT_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51580
EntryNameTPMT_HUMAN
FullNameThiopurine S-methyltransferase
TaxID9606
Evidenceevidence at protein level
Length245
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesTPMT

GO terms

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GOName
GO:0005829 cytosol
GO:0006139 nucleobase-containing compound metabolic process
GO:0008119 thiopurine S-methyltransferase activity
GO:0017144 drug metabolic process
GO:0032259 methylation
GO:1904047 S-adenosyl-L-methionine binding

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR008854 TPMT familyFamilyFamily
IPR025835 Thiopurine S-methyltransferaseFamilyFamily
IPR029063 S-adenosyl-L-methionine-dependent methyltransferaseFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00436 BendroflumethiazideDrugbanksmall molecule
DB00993 AzathioprineDrugbanksmall molecule
DB01021 TrichlormethiazideDrugbanksmall molecule
DB01033 MercaptopurineDrugbanksmall molecule
DB01250 OlsalazineDrugbanksmall molecule
DB01327 CefazolinDrugbanksmall molecule

Interactions

4 interactions